IMR OpenIR
A novel ureteral stent material with antibacterial and reducing encrustation properties
Zhao, J; Cao, ZQ; Ren, L; Chen, SS; Zhang, BC; Liu, R; Yang, K; Yang, K (reprint author), 72 Wenhua Rd, Shenyang 110016, Peoples R China.
2016-11-01
Source PublicationMATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
ISSN0928-4931
Volume68Pages:221-228
AbstractUreteral stents have been used to relieve ureterostenosis. Complications such as infection and encrustation occur in the long time of stent implantation, which is a clinical problem needs to be resolved. Indwelling ureteral stents have shown to develop microbial biofilm that may lead to recurrent infection and encrustation. This study was aiming to reduce those complications by using a novel material, Cu-bearing antibacterial stainless steel. The antibacterial performance, encrustation property, and biocompatibility were examined by SEM, image analysis, MTT and would healing. The in vitro immersion test showed that 316LCu-bearing stainless steel (316LCu-SS) not only inhibited proliferation of bacteria and formation of biofilm, but also had less encrustation deposition. Its antibacterial effectiveness against Escherichia coli reached to 92.7% in the artificial urine for 24 h and 903% in the human urine for 6 h. The encrustation surface coverage percentage was 30.2% by 12 weeks, which was nearly one half of NiTi alloy. The in vitro tests showed that 316LCu-SS had no toxicity, and promoted the migration of urethral epithelial cells. (C) 2016 Elsevier B.V. All rights reserved.
description.department[zhao, jing ; ren, ling ; chen, shanshan ; zhang, bingchun ; liu, rui ; yang, ke] chinese acad sci, inst met res, shenyang 110016, peoples r china ; [cao, zhiqiang] gen hosp shenyang mil reg, shenyang 110840, peoples r china
KeywordCu-bearing Stainless Steel Antibacterial Ureteral Stent Infection Encrustation
Subject AreaMaterials Science, bioMaterials
Funding OrganizationNational Basic Research Program of China (973 Program) [2012CB619101]; National Natural Science Foundation of China [51171186]; Foundation of Jiangsu Collaborative Innovation Center of Biomedical Functional Materials
Indexed Bysci
Language英语
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/76219
Collection中国科学院金属研究所
Corresponding AuthorYang, K (reprint author), 72 Wenhua Rd, Shenyang 110016, Peoples R China.
Recommended Citation
GB/T 7714
Zhao, J,Cao, ZQ,Ren, L,et al. A novel ureteral stent material with antibacterial and reducing encrustation properties[J]. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,2016,68:221-228.
APA Zhao, J.,Cao, ZQ.,Ren, L.,Chen, SS.,Zhang, BC.,...&Yang, K .(2016).A novel ureteral stent material with antibacterial and reducing encrustation properties.MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,68,221-228.
MLA Zhao, J,et al."A novel ureteral stent material with antibacterial and reducing encrustation properties".MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS 68(2016):221-228.
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