|A novel ureteral stent material with antibacterial and reducing encrustation properties|
|Zhao, J; Cao, ZQ; Ren, L; Chen, SS; Zhang, BC; Liu, R; Yang, K; Yang, K (reprint author), 72 Wenhua Rd, Shenyang 110016, Peoples R China.
|发表期刊||MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
|摘要||Ureteral stents have been used to relieve ureterostenosis. Complications such as infection and encrustation occur in the long time of stent implantation, which is a clinical problem needs to be resolved. Indwelling ureteral stents have shown to develop microbial biofilm that may lead to recurrent infection and encrustation. This study was aiming to reduce those complications by using a novel material, Cu-bearing antibacterial stainless steel. The antibacterial performance, encrustation property, and biocompatibility were examined by SEM, image analysis, MTT and would healing. The in vitro immersion test showed that 316LCu-bearing stainless steel (316LCu-SS) not only inhibited proliferation of bacteria and formation of biofilm, but also had less encrustation deposition. Its antibacterial effectiveness against Escherichia coli reached to 92.7% in the artificial urine for 24 h and 903% in the human urine for 6 h. The encrustation surface coverage percentage was 30.2% by 12 weeks, which was nearly one half of NiTi alloy. The in vitro tests showed that 316LCu-SS had no toxicity, and promoted the migration of urethral epithelial cells. (C) 2016 Elsevier B.V. All rights reserved.|
; ren, ling
; chen, shanshan
; zhang, bingchun
; liu, rui
; yang, ke] chinese acad sci, inst met res, shenyang 110016, peoples r china
; [cao, zhiqiang] gen hosp shenyang mil reg, shenyang 110840, peoples r china
|关键词||Cu-bearing Stainless Steel
|学科领域||Materials Science, bioMaterials
|资助者||National Basic Research Program of China (973 Program) [2012CB619101]; National Natural Science Foundation of China ; Foundation of Jiangsu Collaborative Innovation Center of Biomedical Functional Materials
|通讯作者||Yang, K (reprint author), 72 Wenhua Rd, Shenyang 110016, Peoples R China.|
Zhao, J,Cao, ZQ,Ren, L,et al. A novel ureteral stent material with antibacterial and reducing encrustation properties[J]. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,2016,68:221-228.
Zhao, J.,Cao, ZQ.,Ren, L.,Chen, SS.,Zhang, BC.,...&Yang, K .(2016).A novel ureteral stent material with antibacterial and reducing encrustation properties.MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,68,221-228.
Zhao, J,et al."A novel ureteral stent material with antibacterial and reducing encrustation properties".MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS 68(2016):221-228.