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The functional response of bioactive titania-modified three-dimensional Ti-6Al-4V mesh structure toward providing a favorable pathway for intercellular communication and osteoincorporation
Nune, KC; Misra, RDK; Li, SJ; Hao, YL; Zhang, W; Misra, RDK (reprint author), Univ Texas El Paso, Dept Met Mat & Biomed Engn, Biomat & Biomed Engn Res Lab, 500 W Univ Ave, El Paso, TX 79968 USA.
2016-10-01
Source PublicationJOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
ISSN1549-3296
Volume104Issue:10Pages:2488-2501
AbstractThe objective of the study is to fundamentally elucidate the biological response of 3D printed mesh structures subjected to plasma electrolytic oxidation process through the study of osteoblast functions. The cellular activity of plasma electrolytic-oxidized mesh structure was explored in terms of cell-to-cell communication involving proliferation, synthesis of extracellular and intracellular proteins, and mineralization. Upon plasma electrolytic oxidation of the mesh structure, a thin layer of bioactive titania with pore size 1-3 mu m was nucleated on the surface. The combination of microporous bioactive titania and interconnected porous architecture provided the desired pathway for supply of nutrients and oxygen to cells and tissue and a favorable osteogenic microenvironment for tissue on-growth and in-growth, in relation to the unmodified mesh structure. The formation of a confluent layer as envisaged via electron microscopy and quantitative assessment of the expression level of proteins (actin, vinculin, and fibronectin) point toward the determining role of surface-modified mesh structure in modulating osteoblasts functions. (c) 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2488-2501, 2016.
description.department[nune, k. c. ; misra, r. d. k.] univ texas el paso, dept met mat & biomed engn, biomat & biomed engn res lab, 500 w univ ave, el paso, tx 79968 usa ; [li, s. j. ; hao, y. l.] chinese acad sci, inst met res, shenyang natl lab mat sci, 72 wenhua rd, shenyang 110016, peoples r china ; [zhang, w.] chinese acad sci, inst met res, lab corros & protect, shenyang 110016, peoples r china
KeywordMicro-arc Oxidation Mesh Structure Ti6al4v Osteoblasts
Subject AreaEngineering, Biomedical ; Materials Science, bioMaterials
Funding Organization863 project [2015AA033702]; Materials Science and Biomedical Engineering programs of the Department of Metallurgical, Materials, and Biomedical Engineering, University of Texas at El Paso
Indexed Bysci
Language英语
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/76254
Collection中国科学院金属研究所
Corresponding AuthorMisra, RDK (reprint author), Univ Texas El Paso, Dept Met Mat & Biomed Engn, Biomat & Biomed Engn Res Lab, 500 W Univ Ave, El Paso, TX 79968 USA.
Recommended Citation
GB/T 7714
Nune, KC,Misra, RDK,Li, SJ,et al. The functional response of bioactive titania-modified three-dimensional Ti-6Al-4V mesh structure toward providing a favorable pathway for intercellular communication and osteoincorporation[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,2016,104(10):2488-2501.
APA Nune, KC,Misra, RDK,Li, SJ,Hao, YL,Zhang, W,&Misra, RDK .(2016).The functional response of bioactive titania-modified three-dimensional Ti-6Al-4V mesh structure toward providing a favorable pathway for intercellular communication and osteoincorporation.JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,104(10),2488-2501.
MLA Nune, KC,et al."The functional response of bioactive titania-modified three-dimensional Ti-6Al-4V mesh structure toward providing a favorable pathway for intercellular communication and osteoincorporation".JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A 104.10(2016):2488-2501.
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