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The functional response of bioactive titania-modified three-dimensional Ti-6Al-4V mesh structure toward providing a favorable pathway for intercellular communication and osteoincorporation
Nune, KC; Misra, RDK; Li, SJ; Hao, YL; Zhang, W; Misra, RDK (reprint author), Univ Texas El Paso, Dept Met Mat & Biomed Engn, Biomat & Biomed Engn Res Lab, 500 W Univ Ave, El Paso, TX 79968 USA.
2016-10-01
发表期刊JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
ISSN1549-3296
卷号104期号:10页码:2488-2501
摘要The objective of the study is to fundamentally elucidate the biological response of 3D printed mesh structures subjected to plasma electrolytic oxidation process through the study of osteoblast functions. The cellular activity of plasma electrolytic-oxidized mesh structure was explored in terms of cell-to-cell communication involving proliferation, synthesis of extracellular and intracellular proteins, and mineralization. Upon plasma electrolytic oxidation of the mesh structure, a thin layer of bioactive titania with pore size 1-3 mu m was nucleated on the surface. The combination of microporous bioactive titania and interconnected porous architecture provided the desired pathway for supply of nutrients and oxygen to cells and tissue and a favorable osteogenic microenvironment for tissue on-growth and in-growth, in relation to the unmodified mesh structure. The formation of a confluent layer as envisaged via electron microscopy and quantitative assessment of the expression level of proteins (actin, vinculin, and fibronectin) point toward the determining role of surface-modified mesh structure in modulating osteoblasts functions. (c) 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2488-2501, 2016.
部门归属[nune, k. c. ; misra, r. d. k.] univ texas el paso, dept met mat & biomed engn, biomat & biomed engn res lab, 500 w univ ave, el paso, tx 79968 usa ; [li, s. j. ; hao, y. l.] chinese acad sci, inst met res, shenyang natl lab mat sci, 72 wenhua rd, shenyang 110016, peoples r china ; [zhang, w.] chinese acad sci, inst met res, lab corros & protect, shenyang 110016, peoples r china
关键词Micro-arc Oxidation Mesh Structure Ti6al4v Osteoblasts
学科领域Engineering, Biomedical ; Materials Science, bioMaterials
资助者863 project [2015AA033702]; Materials Science and Biomedical Engineering programs of the Department of Metallurgical, Materials, and Biomedical Engineering, University of Texas at El Paso
收录类别sci
语种英语
文献类型期刊论文
条目标识符http://ir.imr.ac.cn/handle/321006/76254
专题中国科学院金属研究所
通讯作者Misra, RDK (reprint author), Univ Texas El Paso, Dept Met Mat & Biomed Engn, Biomat & Biomed Engn Res Lab, 500 W Univ Ave, El Paso, TX 79968 USA.
推荐引用方式
GB/T 7714
Nune, KC,Misra, RDK,Li, SJ,et al. The functional response of bioactive titania-modified three-dimensional Ti-6Al-4V mesh structure toward providing a favorable pathway for intercellular communication and osteoincorporation[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,2016,104(10):2488-2501.
APA Nune, KC,Misra, RDK,Li, SJ,Hao, YL,Zhang, W,&Misra, RDK .(2016).The functional response of bioactive titania-modified three-dimensional Ti-6Al-4V mesh structure toward providing a favorable pathway for intercellular communication and osteoincorporation.JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,104(10),2488-2501.
MLA Nune, KC,et al."The functional response of bioactive titania-modified three-dimensional Ti-6Al-4V mesh structure toward providing a favorable pathway for intercellular communication and osteoincorporation".JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A 104.10(2016):2488-2501.
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