Surface Modification on Biodegradable Magnesium Alloys as Orthopedic Implant Materials to Improve the Bio-adaptability: A Review

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	Surface Modification on Biodegradable Magnesium Alloys as Orthopedic Implant Materials to Improve the Bio-adaptability: A Review
	Wan, P; Tan, LL; Yang, K; Yang, K (reprint author), Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China.
	2016-09-01
发表期刊	JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
ISSN	1005-0302
卷号	32 期号:9 页码:827-834
摘要	Magnesium (Mg) and its alloys as a novel kind of biodegradable material have attracted much fundamental research and valuable exploration to develop its clinical application. Mg alloys degrade too fast at the early stage after implantation, thus commonly leading to some problems such as osteolysis, early fast mechanical loss, hydric bubble aggregation, gap formation between the implants and the tissue. Surface modification is one of the effective methods to control the degradation property of Mg alloys to adapt to the need of organism. Some coatings with bioactive elements have been developed, especially for the micro-arc oxidation coating, which has high adhesion strength and can be added with Ca, P, and Sr elements. Chemical deposition coating including bio-mimetic deposition coating, electro-deposition coating and chemical conversion coating can provide good anticorrosion property as well as better bioactivity with higher Ca and P content in the coating. From the biodegradation study, it can be seen that surface coating protected the Mg alloys at the early stage providing the Mg alloy substrate with lower degradation rate. The biocompatibility study showed that the surface modification could provide the cell and tissue stable and weak alkaline surface micro-environment adapting to the cell adhesion and tissue growth. The surface modification also decreased the mechanical loss at the early stage adapting to the load bearing requirement at this stage. From the interface strength between Mg alloys implants and the surrounding tissue study, it can be seen that the surface modification improved the bio-adhesion of Mg alloys with the surrounding tissue, which is believed to be contributed to the tissue adaptability of the surface modification. Therefore, the surface modification adapts the biodegradable magnesium alloys to the need of biodegradation, biocompatibility and mechanical loss property. For the different clinical application, different surface modification methods can be provided to adapt to the clinical requirements for the Mg alloy implants. Copyright (C) 2016, The editorial office of Journal of Materials Science & Technology. Published by Elsevier Limited.
部门归属	[wan, peng ; tan, lili ; yang, ke] chinese acad sci, inst met res, shenyang 110016, peoples r china
关键词	Bio-adaptability Coating Biodegradable Magnesium Alloys Orthopedic Implants
学科领域	Materials Science, Multidisciplinary ; Metallurgy & Metallurgical Engineering
资助者	National Basic Research Program of China (973 Program) [2012CB619101]
收录类别	sci
语种	英语
WOS记录号	WOS:000384625900005
引用统计	被引频次：173[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/76280
专题	中国科学院金属研究所
通讯作者	Yang, K (reprint author), Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China.
推荐引用方式 GB/T 7714	Wan, P,Tan, LL,Yang, K,et al. Surface Modification on Biodegradable Magnesium Alloys as Orthopedic Implant Materials to Improve the Bio-adaptability: A Review[J]. JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,2016,32(9):827-834.
APA	Wan, P,Tan, LL,Yang, K,&Yang, K .(2016).Surface Modification on Biodegradable Magnesium Alloys as Orthopedic Implant Materials to Improve the Bio-adaptability: A Review.JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,32(9),827-834.
MLA	Wan, P,et al."Surface Modification on Biodegradable Magnesium Alloys as Orthopedic Implant Materials to Improve the Bio-adaptability: A Review".JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY 32.9(2016):827-834.