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Enoxacin-loaded Poly (lactic-co-glycolic acid) Coating on Porous Magnesium Scaffold as a Drug Delivery System: Antibacterial Properties and Inhibition of Osteoclastic Bone Resorption
Li, Y; Liu, XQ; Tan, LL; Ren, L; Wan, P; Hao, YQ; Qu, XH; Yang, K; Dai, KR; Dai, KR (reprint author), Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 9,Dept Orthopaed Surg, Shanghai Key Lab Orthopaed Implants, Shanghai 200011, Peoples R China.; Yang, K (reprint author), Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China.
2016-09-01
发表期刊JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
ISSN1005-0302
卷号32期号:9页码:865-873
摘要Implant-associated infection remains a difficult medical problem in orthopedic surgery. Therefore, the development of multifunctional bone implants for treating infection and regenerating lost bone tissue, which may be a result of infection, is important. In the present study, we report the fabrication of enoxacinloaded poly (lactic-co-glycolic acid) (PLGA) coating on porous magnesium scaffold (Enox-PLGA-Mg) which combine the favorable properties of magnesium, the antibacterial property and the effect of inhibition of osteoclastic bone resorption of enoxacin. The drug loaded PLGA coating of Mg scaffold enables higher drug loading efficiency (52%-56%) than non-coating enoxacin loaded Mg scaffold (Enox-Mg) (4%-5%). EnoxPLGA-Mg exhibits sustained drug release for more than 14 days, and this controlled release of enoxacin significantly inhibits bacterial adhesion and prevented biofilm formation by Staphylococcus epidermidis (ATCC35984) and Staphylococcus aureus (ATCC25923). Biocompatibility tests with Balb/c mouse embryo fibroblasts (Ball* 3T3 cells) indicate that PLGA-Mg has better biocompatibility than Mg. Finally, we also demonstrate that Enox-PLGA-Mg extract potently inhibited osteoclast formation in vitro. Therefore, EnoxPLGA-Mg has the potential to be used as a multifunctional controlled drug delivery system bone scaffolds to prevent and/or treat orthopedic peri-implant infections. Copyright (C) 2016, The editorial office of Journal of Materials Science & Technology. Published by Elsevier Limited.
部门归属[li, yang ; hao, yongqiang ; qu, xinhua ; dai, kerong] shanghai jiao tong univ, sch med, shanghai peoples hosp 9,dept orthopaed surg, shanghai key lab orthopaed implants, shanghai 200011, peoples r china ; [liu, xuqiang] nanchang univ, affiliated hosp 1, dept orthoped, artificial joint engn & technol res ctr jiangxi p, nanchang 330006, peoples r china ; [tan, lili ; ren, ling ; wan, peng ; yang, ke] chinese acad sci, inst met res, shenyang 110016, peoples r china
关键词Porous Magnesium Scaffold Poly (Lactic-co-glycolic Acid) (Plga) Drug Delivery System Bactericidal Activity Enoxacin Osteolysis
学科领域Materials Science, Multidisciplinary ; Metallurgy & Metallurgical Engineering
资助者Key National Basic Research Program of China [2012CB619101]; National Natural Science Foundation of China [81190133]; National Natural Science Foundation for the Youth of China [81401852, 31500777]; Doctoral Innovation Fund Projects from Shanghai Jiao Tong University School of Medicine [BXJ201430]; Natural Science Foundation of Shanghai [14ZR1424000]; Shanghai Municipal Education Commission and Shanghai Education Development Foundation [14CG14]
收录类别sci
语种英语
文献类型期刊论文
条目标识符http://ir.imr.ac.cn/handle/321006/76282
专题中国科学院金属研究所
通讯作者Qu, XH; Dai, KR (reprint author), Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 9,Dept Orthopaed Surg, Shanghai Key Lab Orthopaed Implants, Shanghai 200011, Peoples R China.; Yang, K (reprint author), Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China.
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GB/T 7714
Li, Y,Liu, XQ,Tan, LL,et al. Enoxacin-loaded Poly (lactic-co-glycolic acid) Coating on Porous Magnesium Scaffold as a Drug Delivery System: Antibacterial Properties and Inhibition of Osteoclastic Bone Resorption[J]. JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,2016,32(9):865-873.
APA Li, Y.,Liu, XQ.,Tan, LL.,Ren, L.,Wan, P.,...&Yang, K .(2016).Enoxacin-loaded Poly (lactic-co-glycolic acid) Coating on Porous Magnesium Scaffold as a Drug Delivery System: Antibacterial Properties and Inhibition of Osteoclastic Bone Resorption.JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,32(9),865-873.
MLA Li, Y,et al."Enoxacin-loaded Poly (lactic-co-glycolic acid) Coating on Porous Magnesium Scaffold as a Drug Delivery System: Antibacterial Properties and Inhibition of Osteoclastic Bone Resorption".JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY 32.9(2016):865-873.
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