Design and characterization of a novel nickel-free cobalt-base alloy for intravascular stents

IMR OpenIR

	Design and characterization of a novel nickel-free cobalt-base alloy for intravascular stents
	Wang, Qiang; Ren, Yibin; Shahzad, M. Babar; Zhang, Wei; Pan, Xumeng; Zhang, Song; Zhang, Dan; Wang, Q (reprint author), China Med Univ, Sch Stomatol, Shenyang 110002, Peoples R China.
	2017-08-01
发表期刊	MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
ISSN	0928-4931
卷号	77 页码:565-571
摘要	Co-Cr-W-Ni alloy (L605) with high tensile strength is used in coronary stents. The thickness of individual strut of the stent is reduced which can decrease the stent restenosis rate. However, about 10%Ni element content in L605 is found to cause allergic reactions and pulmonary embolism, similar to the traditional 316L stainless steel. In this study, a novel nickel-free cobalt-base alloy Co-20Cr-12Fe-18Mn-2Mo-4W-N (wt%) was designed and fabricated in order to efficiently avoid the potential hazards of Ni element. Fe and Mn, essential elements of human body, were added in the alloy to substitute part of Co element. In comparison to L605 alloy, the tensile strength of the new alloy was higher than 1000 MPa while elongation was above 55%. The pitting potential of the new alloy was measured close to 1000 mV, also higher than that of L605 alloy. CCK-8 test indicated that the cytotoxicity of the new alloy is grade 1, reflecting that Co-20Cr-12Fe-18Mn-2Mo-4W-N alloy has no cytotoxic effects. There was no significant difference in the apoptosis rates between Co-20Cr-12Fe-18Mn-2Mo-4W-N and L605 alloy. The newly developed cobalt -base alloy showed excellent mechanical, corrosion resistance and biological properties, which could make it a desirable material for future clinical investigations. (C) 2017 Elsevier B.V. All rights reserved.; Co-Cr-W-Ni alloy (L605) with high tensile strength is used in coronary stents. The thickness of individual strut of the stent is reduced which can decrease the stent restenosis rate. However, about 10%Ni element content in L605 is found to cause allergic reactions and pulmonary embolism, similar to the traditional 316L stainless steel. In this study, a novel nickel-free cobalt-base alloy Co-20Cr-12Fe-18Mn-2Mo-4W-N (wt%) was designed and fabricated in order to efficiently avoid the potential hazards of Ni element. Fe and Mn, essential elements of human body, were added in the alloy to substitute part of Co element. In comparison to L605 alloy, the tensile strength of the new alloy was higher than 1000 MPa while elongation was above 55%. The pitting potential of the new alloy was measured close to 1000 mV, also higher than that of L605 alloy. CCK-8 test indicated that the cytotoxicity of the new alloy is grade 1, reflecting that Co-20Cr-12Fe-18Mn-2Mo-4W-N alloy has no cytotoxic effects. There was no significant difference in the apoptosis rates between Co-20Cr-12Fe-18Mn-2Mo-4W-N and L605 alloy. The newly developed cobalt -base alloy showed excellent mechanical, corrosion resistance and biological properties, which could make it a desirable material for future clinical investigations. (C) 2017 Elsevier B.V. All rights reserved.
部门归属	[wang, qiang ; zhang, wei ; pan, xumeng ; zhang, dan] china med univ, sch stomatol, shenyang 110002, peoples r china ; [wang, qiang ; zhang, song] shenyang univ technol, sch mat sci & engn, shenyang 110870, peoples r china ; [wang, qiang] shenyang dalu laser grp co ltd, shenyang 110002, peoples r china ; [ren, yibin ; shahzad, m. babar] chinese acad sci, inst met res, shenyang 110016, peoples r china
关键词	Cobalt-base Alloy Intravascular Stent Nickel-free Cytotoxicity
学科领域	Materials Science, bioMaterials
资助者	National Natural Science Foundation [31370976, 81500897]; National Key Research and Development Program of China [2016YFB1100204]; Youth Foundation of School of Stomatology, China Medical University [K101593-17-05]
收录类别	SCI
语种	英语
WOS记录号	WOS:000403381200064
引用统计	被引频次：14[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/78032
专题	中国科学院金属研究所
通讯作者	Wang, Q (reprint author), China Med Univ, Sch Stomatol, Shenyang 110002, Peoples R China.
推荐引用方式 GB/T 7714	Wang, Qiang,Ren, Yibin,Shahzad, M. Babar,et al. Design and characterization of a novel nickel-free cobalt-base alloy for intravascular stents[J]. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,2017,77:565-571.
APA	Wang, Qiang.,Ren, Yibin.,Shahzad, M. Babar.,Zhang, Wei.,Pan, Xumeng.,...&Wang, Q .(2017).Design and characterization of a novel nickel-free cobalt-base alloy for intravascular stents.MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,77,565-571.
MLA	Wang, Qiang,et al."Design and characterization of a novel nickel-free cobalt-base alloy for intravascular stents".MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS 77(2017):565-571.