IMR OpenIR
In Vivo Study on Degradation Behavior and Histologic Response of Pure Magnesium in Muscles
Chen, Shanshan; Tan, Lili; Zhang, Bingchun; Xia, Yonghui; Xu, Ke; Yang, Ke; Yang, K (reprint author), Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China.
2017-05-01
发表期刊JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
ISSN1005-0302
卷号33期号:5页码:469-474
摘要When an orthopedics device is implanted into bone injury site, it will contact the soft tissue (skeletal muscle, fascia, ligament etc.) except for bone. Magnesium based biodegradable metals are becoming an important research object in orthopedics due to their bioactivity to promote bone healing. In this study, pure Mg rods with and without chemical conversion coating were implanted into the muscle tissue of rabbits. Implants and their surrounding tissues were taken out for weight loss measurement, cross-sectional scanning electron microscopy observation, elemental distribution analysis and histological examination. The results showed that the chemical conversion coating would increase the in vivo corrosion resistance of pure Mg and decrease the accumulation of calcium (Ca) and phosphorus (P) elements around the implants. For the bare magnesium implant, both Ca and P contents in the surrounding tissues increased at the initial stage of implantation and then decreased at 12 weeks implantation, while for the magnesium with chemical conversion coating, Ca and P contents in the surrounding tissues decreased with the implantation time, but were not significant. The histological results demonstrated that there was no calcification in the muscle tissue with implantation of magnesium for up to 12 weeks. The chemical conversion coating not only increased the in vivo corrosion resistance of pure Mg, but also avoided the depositions of Ca and P in the surrounding tissues, meaning that pure magnesium should be bio-safe when contacting with muscle tissues. Copyright (C) 2017, The editorial office of Journal of Materials Science & Technology. Published by Elsevier Limited.; When an orthopedics device is implanted into bone injury site, it will contact the soft tissue (skeletal muscle, fascia, ligament etc.) except for bone. Magnesium based biodegradable metals are becoming an important research object in orthopedics due to their bioactivity to promote bone healing. In this study, pure Mg rods with and without chemical conversion coating were implanted into the muscle tissue of rabbits. Implants and their surrounding tissues were taken out for weight loss measurement, cross-sectional scanning electron microscopy observation, elemental distribution analysis and histological examination. The results showed that the chemical conversion coating would increase the in vivo corrosion resistance of pure Mg and decrease the accumulation of calcium (Ca) and phosphorus (P) elements around the implants. For the bare magnesium implant, both Ca and P contents in the surrounding tissues increased at the initial stage of implantation and then decreased at 12 weeks implantation, while for the magnesium with chemical conversion coating, Ca and P contents in the surrounding tissues decreased with the implantation time, but were not significant. The histological results demonstrated that there was no calcification in the muscle tissue with implantation of magnesium for up to 12 weeks. The chemical conversion coating not only increased the in vivo corrosion resistance of pure Mg, but also avoided the depositions of Ca and P in the surrounding tissues, meaning that pure magnesium should be bio-safe when contacting with muscle tissues. Copyright (C) 2017, The editorial office of Journal of Materials Science & Technology. Published by Elsevier Limited.
部门归属[chen, shanshan ; tan, lili ; zhang, bingchun ; yang, ke] chinese acad sci, inst met res, shenyang 110016, peoples r china ; [xia, yonghui ; xu, ke] china med univ, dept radiol, affiliated hosp 1, key lab diagnost imaging & intervent radiol, shenyang 110001, liaoning provin, peoples r china
关键词Pure Magnesium Degradation Behavior Histologic Response Muscle Tissue
学科领域Materials Science, Multidisciplinary ; Metallurgy & Metallurgical Engineering
资助者National Science & Technology Pillar Program of China [2012BAl18B01]; National Basic Research Program of China ("973 Program") [2012CB619101]; National Natural Science Foundation of China [81171443]; Foundation of Jiangsu Collaborative Innovation Center of Biomedical Functional Materials
收录类别SCI
语种英语
文献类型期刊论文
条目标识符http://ir.imr.ac.cn/handle/321006/78151
专题中国科学院金属研究所
通讯作者Yang, K (reprint author), Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China.
推荐引用方式
GB/T 7714
Chen, Shanshan,Tan, Lili,Zhang, Bingchun,et al. In Vivo Study on Degradation Behavior and Histologic Response of Pure Magnesium in Muscles[J]. JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,2017,33(5):469-474.
APA Chen, Shanshan.,Tan, Lili.,Zhang, Bingchun.,Xia, Yonghui.,Xu, Ke.,...&Yang, K .(2017).In Vivo Study on Degradation Behavior and Histologic Response of Pure Magnesium in Muscles.JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,33(5),469-474.
MLA Chen, Shanshan,et al."In Vivo Study on Degradation Behavior and Histologic Response of Pure Magnesium in Muscles".JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY 33.5(2017):469-474.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Chen, Shanshan]的文章
[Tan, Lili]的文章
[Zhang, Bingchun]的文章
百度学术
百度学术中相似的文章
[Chen, Shanshan]的文章
[Tan, Lili]的文章
[Zhang, Bingchun]的文章
必应学术
必应学术中相似的文章
[Chen, Shanshan]的文章
[Tan, Lili]的文章
[Zhang, Bingchun]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。