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题名: Lightweight Open-Cell Scaffolds from Sea Urchin Spines with Superior Material Properties for Bone Defect Repair
作者: Cao, Lei;  Li, Xiaokang;  Zhou, Xiaoshu;  Li, Yong;  Vecchio, Kenneth S.;  Yang, Lina;  Cui, Wei;  Yang, Rui;  Zhu, Yue;  Guo, Zheng;  Zhang, Xing
发表日期: 2017-3-22
摘要: Sea urchin spines (Heterocentrotus mammillatus), with a hierarchical open-cell structure similar to that of human trabecular bone and superior mechanical property (compressive strength similar to 43.4 MPa) suitable for machining to shape, were explored for potential applications of bone defect repair. Finite element analyses reveal that the compressive stress concentrates along the dense growth rings and dissipates through strut structures of the stereoms, indicating that the exquisite mesostructures play an important role in high strength-to-weight ratios. The fracture strength of magnesium-substituted tricalcium phosphate beta-TCMP) scaffolds produced by hydrothermal conversion of urchin spines is about 9.3 MPa, comparable to that of human trabecular bone. New bone forms along outer surfaces of beta-TCMP scaffolds after implantation in rabbit femoral defects for one month and grows into the majority of the inner open-cell spaces postoperation in three months, showing tight interface between the scaffold and regenerative bone tissue. Fusion of beagle lumbar facet joints using a Ti-6Al-4V cage and beta-TCMP scaffold can be completed within seven months with obvious biodegradation of the beta-TCMP scaffold, which is nearly completely degraded and replaced by newly formed bone ten months after implantation. Thus, sea urchin spines suitable for machining to shape have advantages for production of biodegradable artificial grafts for bone defect repair.
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Recommended Citation:
Cao, Lei,Li, Xiaokang,Zhou, Xiaoshu,et al. Lightweight Open-cell Scaffolds From Sea Urchin Spines With Superior Material Properties For Bone Defect Repair[J]. Acs Applied Materials & Interfaces,2017,9(11):9862-9870.

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