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Lightweight Open-Cell Scaffolds from Sea Urchin Spines with Superior Material Properties for Bone Defect Repair
Cao, Lei; Li, Xiaokang; Zhou, Xiaoshu; Li, Yong; Vecchio, Kenneth S.; Yang, Lina; Cui, Wei; Yang, Rui; Zhu, Yue; Guo, Zheng; Zhang, Xing; Zhang, X (reprint author), Chinese Acad Sci, Shenyang Natl Lab Mat Sci, Inst Met Res, Shenyang 110016, Liaoning, Peoples R China.; Guo, Z (reprint author), Fourth Mil Med Univ, Xijing Hosp, Dept Orthoped, Xian 710032, Shaanxi, Peoples R China.; Zhu, Y (reprint author), China Med Univ, Hosp 1, Dept Orthoped, Shenyang 110001, Liaoning, Peoples R China.; Zhang, X (reprint author), Univ Sci & Technol China, Sch Mat Sci, Hefei 230026, Anhui, Peoples R China.
2017-03-22
Source PublicationACS APPLIED MATERIALS & INTERFACES
ISSN1944-8244
Volume9Issue:11Pages:9862-9870
AbstractSea urchin spines (Heterocentrotus mammillatus), with a hierarchical open-cell structure similar to that of human trabecular bone and superior mechanical property (compressive strength similar to 43.4 MPa) suitable for machining to shape, were explored for potential applications of bone defect repair. Finite element analyses reveal that the compressive stress concentrates along the dense growth rings and dissipates through strut structures of the stereoms, indicating that the exquisite mesostructures play an important role in high strength-to-weight ratios. The fracture strength of magnesium-substituted tricalcium phosphate beta-TCMP) scaffolds produced by hydrothermal conversion of urchin spines is about 9.3 MPa, comparable to that of human trabecular bone. New bone forms along outer surfaces of beta-TCMP scaffolds after implantation in rabbit femoral defects for one month and grows into the majority of the inner open-cell spaces postoperation in three months, showing tight interface between the scaffold and regenerative bone tissue. Fusion of beagle lumbar facet joints using a Ti-6Al-4V cage and beta-TCMP scaffold can be completed within seven months with obvious biodegradation of the beta-TCMP scaffold, which is nearly completely degraded and replaced by newly formed bone ten months after implantation. Thus, sea urchin spines suitable for machining to shape have advantages for production of biodegradable artificial grafts for bone defect repair.; Sea urchin spines (Heterocentrotus mammillatus), with a hierarchical open-cell structure similar to that of human trabecular bone and superior mechanical property (compressive strength similar to 43.4 MPa) suitable for machining to shape, were explored for potential applications of bone defect repair. Finite element analyses reveal that the compressive stress concentrates along the dense growth rings and dissipates through strut structures of the stereoms, indicating that the exquisite mesostructures play an important role in high strength-to-weight ratios. The fracture strength of magnesium-substituted tricalcium phosphate beta-TCMP) scaffolds produced by hydrothermal conversion of urchin spines is about 9.3 MPa, comparable to that of human trabecular bone. New bone forms along outer surfaces of beta-TCMP scaffolds after implantation in rabbit femoral defects for one month and grows into the majority of the inner open-cell spaces postoperation in three months, showing tight interface between the scaffold and regenerative bone tissue. Fusion of beagle lumbar facet joints using a Ti-6Al-4V cage and beta-TCMP scaffold can be completed within seven months with obvious biodegradation of the beta-TCMP scaffold, which is nearly completely degraded and replaced by newly formed bone ten months after implantation. Thus, sea urchin spines suitable for machining to shape have advantages for production of biodegradable artificial grafts for bone defect repair.
description.department[cao, lei ; yang, lina ; cui, wei ; yang, rui ; zhang, xing] chinese acad sci, shenyang natl lab mat sci, inst met res, shenyang 110016, liaoning, peoples r china ; [li, xiaokang ; li, yong ; guo, zheng] fourth mil med univ, xijing hosp, dept orthoped, xian 710032, shaanxi, peoples r china ; [zhou, xiaoshu ; zhu, yue] china med univ, hosp 1, dept orthoped, shenyang 110001, liaoning, peoples r china ; [vecchio, kenneth s.] univ calif san diego, nanoengn dept, la jolla, ca 92093 usa ; [yang, rui ; zhang, xing] univ sci & technol china, sch mat sci, hefei 230026, anhui, peoples r china
KeywordSea Urchin Spines Lightweight Scaffolds Open-cell Structure Mechanical Property Finite Element Analysis Bone Defect Repair
Subject AreaNanoscience & Nanotechnology ; Materials Science, Multidisciplinary
Funding OrganizationNational Natural Science Foundation of China [31300788, 81171773]; National High-Tech R&D Program of China (863 program) [2015AA033702]; Hundred-Talent Program from Chinese Academy of Sciences
Indexed BySCI
Language英语
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/78225
Collection中国科学院金属研究所
Corresponding AuthorZhang, X (reprint author), Chinese Acad Sci, Shenyang Natl Lab Mat Sci, Inst Met Res, Shenyang 110016, Liaoning, Peoples R China.; Guo, Z (reprint author), Fourth Mil Med Univ, Xijing Hosp, Dept Orthoped, Xian 710032, Shaanxi, Peoples R China.; Zhu, Y (reprint author), China Med Univ, Hosp 1, Dept Orthoped, Shenyang 110001, Liaoning, Peoples R China.; Zhang, X (reprint author), Univ Sci & Technol China, Sch Mat Sci, Hefei 230026, Anhui, Peoples R China.
Recommended Citation
GB/T 7714
Cao, Lei,Li, Xiaokang,Zhou, Xiaoshu,et al. Lightweight Open-Cell Scaffolds from Sea Urchin Spines with Superior Material Properties for Bone Defect Repair[J]. ACS APPLIED MATERIALS & INTERFACES,2017,9(11):9862-9870.
APA Cao, Lei.,Li, Xiaokang.,Zhou, Xiaoshu.,Li, Yong.,Vecchio, Kenneth S..,...&Zhang, X .(2017).Lightweight Open-Cell Scaffolds from Sea Urchin Spines with Superior Material Properties for Bone Defect Repair.ACS APPLIED MATERIALS & INTERFACES,9(11),9862-9870.
MLA Cao, Lei,et al."Lightweight Open-Cell Scaffolds from Sea Urchin Spines with Superior Material Properties for Bone Defect Repair".ACS APPLIED MATERIALS & INTERFACES 9.11(2017):9862-9870.
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