Advanced   Register
IMR OpenIR  > 中国科学院金属研究所  > 期刊论文

题名: PEGylated Au@Pt Nanodendrites as Novel Theranostic Agents for Computed Tomography Imaging and Photothermal/Radiation Synergistic Therapy
作者: Liu, Xu;  Zhang, Xing;  Zhu, Mo;  Lin, Guanghui;  Liu, Jian;  Zhou, Zhufa;  Tian, Xin;  Pan, Yue
发表日期: 2017-1-11
摘要: The integration of photothermal therapy (PTT) with radiation therapy (RT) in a single nanoscale platform is believed to have considerable potential for cancer therapy. In this work, the rationally designed PEGylated Au@Pt nanodendrites (NDs) have been developed as a-novel X-ray computed tomography (CT) and PTT/RT enhanced theranostic agent for cancer therapy. The absorption of Au@Pt NDs was turned to the near-infrared region with the growth of Pt nanobranches and thus enhances the efficacy of PTT. Furthermore, because of the high atomic number (high Z) of Au as well as Pt, Au@Pt NDs significantly enhanced lethal effects of RT by inducing a highly localized radiation dose within cancer cells. More importantly, the combination of Au@Pt ND-enhanced RT with PTT suppressed,cancer cell growth more efficiently than that RT or PTT alone did, indicating a synergistic effect. Meanwhile, the Au@Pt NDs also possess significant CT imaging signal enhancement that has the potential to guide PTT/RT for cancers. The integrated strategy significantly improved CT and PTT/RT of cancer cells with mild laser and radiation. Because of these advantages, Au@Pt NDs have become appealing and effective agents for cancer theranostic.
Appears in Collections:中国科学院金属研究所_期刊论文

Files in This Item:

There are no files associated with this item.

Recommended Citation:
Liu, Xu,Zhang, Xing,Zhu, Mo,et al. Pegylated Au@pt Nanodendrites As Novel Theranostic Agents For Computed Tomography Imaging And Photothermal/radiation Synergistic Therapy[J]. Acs Applied Materials & Interfaces,2017,9(1):279-285.

SCI Citaion Data:
 Recommend this item
 Sava as my favorate item
 Show this item's statistics
 Export Endnote File
Google Scholar
 Similar articles in Google Scholar
 [Liu, Xu]'s Articles
 [Zhang, Xing]'s Articles
 [Zhu, Mo]'s Articles
CSDL cross search
 Similar articles in CSDL Cross Search
 [Liu, Xu]‘s Articles
 [Zhang, Xing]‘s Articles
 [Zhu, Mo]‘s Articles
Scirus search
 Similar articles in Scirus
Related Copyright Policies
Social Bookmarking
  Add to CiteULike  Add to Connotea  Add to  Add to Digg  Add to Reddit 
所有评论 (0)
内 容:
Email:  *
验证码:   刷新
标 题:
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.



Valid XHTML 1.0!
Copyright © 2007-2018  中国科学院金属研究所  -Feedback
Powered by CSpace