Advanced   Register
IMR OpenIR  > 中国科学院金属研究所  > 期刊论文

题名: Characterization of synergistic anti-tumor effects of doxorubicin and p53 via graphene oxide-polyethyleneimine nanocarriers
作者: Xie, Bei;  Yi, Jipeng;  Peng, Jian;  Zhang, Xing;  Lei, Lei;  Zhao, Dapeng;  Lei, Zhixin;  Nie, Hemin
发表日期: 2017-8-1
摘要: Co-delivery of chemical drugs and therapeutic genes for synergistic therapy provides a promising strategy to treat devastating diseases. However, the real-time coordination patterns between chemical drugs and therapeutic genes remain poorly understood. Herein, the complexes of doxorubicin/graphene oxidepolyethyleneimine/p53 plasmid (Dox/GO-PEI/p53) were fabricated and employed to investigate the synergistic manner between Dox and p53 in the inhibition of HeLa cell growth. GO was conjugated with PEI to form the GO-PEI backbone as the delivery vector. The GO backbone provided surfaces with a high specific area to load Dox via the pi-pi stacking interaction, and was able to release Dox significantly faster at pH 5.0 than at pH 7.0, while the positively charged PEI section of GO-PEI could condense plasmids into GO-PEI/DNA nanoparticles via the electrostatic interaction. The nanoparticles efficiently mediated the transfection of DNA in HeLa cells, with lower cytotoxicity compared to PEI/DNA nanoparticles. Furthermore, the complexes of Dox/GO-PEI/p53 released Dox and expressed p53 gene in a sequential manner, and showed successive inhibition of the in vitro growth of HeLa cells. This type of drug/GO-PEI/DNA complex can be employed as a platform to investigate the coordination pattern between chemical drugs and therapeutic genes for tumor therapy. (C) 2017 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science & Technology.
刊名: JOURNAL MATER SCI TECHNOL
Appears in Collections:中国科学院金属研究所_期刊论文

Files in This Item:

There are no files associated with this item.




Recommended Citation:
Xie, Bei,Yi, Jipeng,Peng, Jian,et al. Characterization Of Synergistic Anti-tumor Effects Of Doxorubicin And P53 Via Graphene Oxide-polyethyleneimine Nanocarriers[J]. Journal Mater Sci Technol,2017,33(8):807-814.

SCI Citaion Data:
Service
 Recommend this item
 Sava as my favorate item
 Show this item's statistics
 Export Endnote File
Google Scholar
 Similar articles in Google Scholar
 [Xie, Bei]'s Articles
 [Yi, Jipeng]'s Articles
 [Peng, Jian]'s Articles
CSDL cross search
 Similar articles in CSDL Cross Search
 [Xie, Bei]‘s Articles
 [Yi, Jipeng]‘s Articles
 [Peng, Jian]‘s Articles
Scirus search
 Similar articles in Scirus
Related Copyright Policies
Null
Social Bookmarking
  Add to CiteULike  Add to Connotea  Add to Del.icio.us  Add to Digg  Add to Reddit 
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2018  中国科学院金属研究所  -Feedback
Powered by CSpace