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A unique hybrid-structured surface produced by rapid electrochemical anodization enhances bio-corrosion resistance and bone cell responses of beta-type Ti-24Nb-4Zr-8Sn alloy
Liu, CF; Lee, TH; Liu, JF; Hou, WT; Li, SJ; Hao, YL; Pan, HB; Huang, HH; Huang, HH (reprint author), Natl Yang Ming Univ, Inst Oral Biol, Taipei, Taiwan.; Huang, HH (reprint author), Natl Yang Ming Univ, Dept Dent, Taipei, Taiwan.; Huang, HH (reprint author), China Med Univ, Grad Inst Basic Med Sci, Taichung, Taiwan.; Huang, HH (reprint author), China Med Univ Hosp, Dept Med Res, Taichung, Taiwan.; Huang, HH (reprint author), Asia Univ, Dept Bioinformat & Med Engn, Taichung, Taiwan.; Huang, HH (reprint author), Taipei Vet Gen Hosp, Dept Stomatol, Taipei, Taiwan.; Huang, HH (reprint author), Taipei City Hosp, Dept Educ & Res, Taipei, Taiwan.
2018-04-26
发表期刊SCIENTIFIC REPORTS
ISSN2045-2322
卷号8页码:-
摘要Ti-24Nb-4Zr-8Sn (Ti2448), a new beta-type Ti alloy, consists of nontoxic elements and exhibits a low uniaxial tensile elastic modulus of approximately 45 GPa for biomedical implant applications. Nevertheless, the bio-corrosion resistance and biocompatibility of Ti2448 alloys must be improved for long-term clinical use. In this study, a rapid electrochemical anodization treatment was used on Ti2448 alloys to enhance the bio-corrosion resistance and bone cell responses by altering the surface characteristics. The proposed anodization process produces a unique hybrid oxide layer (thickness 50-120 nm) comprising a mesoporous outer section and a dense inner section. Experiment results show that the dense inner section enhances the bio-corrosion resistance. Moreover, the mesoporous surface topography, which is on a similar scale as various biological species, improves the wettability, protein adsorption, focal adhesion complex formation and bone cell differentiation. Outside-in signals can be triggered through the interaction of integrins with the mesoporous topography to form the focal adhesion complex and to further induce osteogenic differentiation pathway. These results demonstrate that the proposed electrochemical anodization process for Ti2448 alloys with a low uniaxial tensile elastic modulus has the potential for biomedical implant applications.; Ti-24Nb-4Zr-8Sn (Ti2448), a new beta-type Ti alloy, consists of nontoxic elements and exhibits a low uniaxial tensile elastic modulus of approximately 45 GPa for biomedical implant applications. Nevertheless, the bio-corrosion resistance and biocompatibility of Ti2448 alloys must be improved for long-term clinical use. In this study, a rapid electrochemical anodization treatment was used on Ti2448 alloys to enhance the bio-corrosion resistance and bone cell responses by altering the surface characteristics. The proposed anodization process produces a unique hybrid oxide layer (thickness 50-120 nm) comprising a mesoporous outer section and a dense inner section. Experiment results show that the dense inner section enhances the bio-corrosion resistance. Moreover, the mesoporous surface topography, which is on a similar scale as various biological species, improves the wettability, protein adsorption, focal adhesion complex formation and bone cell differentiation. Outside-in signals can be triggered through the interaction of integrins with the mesoporous topography to form the focal adhesion complex and to further induce osteogenic differentiation pathway. These results demonstrate that the proposed electrochemical anodization process for Ti2448 alloys with a low uniaxial tensile elastic modulus has the potential for biomedical implant applications.
部门归属[liu, chia-fei ; huang, her-hsiung] natl yang ming univ, inst oral biol, taipei, taiwan ; [lee, tzu-hsin] changhua christian hosp, dept dent, changhua, taiwan ; [liu, jeng-fen] taichung vet gen hosp, dept stomatol, taichung, taiwan ; [hou, wen-tao ; li, shu-jun ; hao, yu-lin] chinese acad sci, shenyang natl lab mat sci, inst met res, shenyang, liaoning, peoples r china ; [pan, haobo] chinese acad sci, shenzhen inst adv technol, ctr human tissues & organs degenerat, shenzhen, peoples r china ; [huang, her-hsiung] natl yang ming univ, dept dent, taipei, taiwan ; [huang, her-hsiung] china med univ, grad inst basic med sci, taichung, taiwan ; [huang, her-hsiung] china med univ hosp, dept med res, taichung, taiwan ; [huang, her-hsiung] asia univ, dept bioinformat & med engn, taichung, taiwan ; [huang, her-hsiung] taipei vet gen hosp, dept stomatol, taipei, taiwan ; [huang, her-hsiung] taipei city hosp, dept educ & res, taipei, taiwan
关键词Elastic-deformation Behavior Biomedical Titanium-alloys Mechanical-properties In-vitro Osteoblast Differentiation Nanoscale Topography Protein Adsorption Orthodontic Wires Anodic-oxidation Focal Adhesion
学科领域Multidisciplinary Sciences
资助者Ministry of Science and Technology, Taiwan [MOST 98-2314-B-010-011-MY3, 104-2221-E-040-003, 105-2221-E-040-001]; Chinese MOST [2017YFC1104901, 2016YFC110261]; Key Research Program of Frontier Sciences, CAS [QYZDJ-SSWJSC031-02]; National Natural Science Foundation of China [51591190, 51771209, 51631007]; Shenzhen Peacock Program [110811003586331]
收录类别SCI
语种英语
文献类型期刊论文
条目标识符http://ir.imr.ac.cn/handle/321006/79355
专题中国科学院金属研究所
通讯作者Huang, HH (reprint author), Natl Yang Ming Univ, Inst Oral Biol, Taipei, Taiwan.; Huang, HH (reprint author), Natl Yang Ming Univ, Dept Dent, Taipei, Taiwan.; Huang, HH (reprint author), China Med Univ, Grad Inst Basic Med Sci, Taichung, Taiwan.; Huang, HH (reprint author), China Med Univ Hosp, Dept Med Res, Taichung, Taiwan.; Huang, HH (reprint author), Asia Univ, Dept Bioinformat & Med Engn, Taichung, Taiwan.; Huang, HH (reprint author), Taipei Vet Gen Hosp, Dept Stomatol, Taipei, Taiwan.; Huang, HH (reprint author), Taipei City Hosp, Dept Educ & Res, Taipei, Taiwan.
推荐引用方式
GB/T 7714
Liu, CF,Lee, TH,Liu, JF,et al. A unique hybrid-structured surface produced by rapid electrochemical anodization enhances bio-corrosion resistance and bone cell responses of beta-type Ti-24Nb-4Zr-8Sn alloy[J]. SCIENTIFIC REPORTS,2018,8:-.
APA Liu, CF.,Lee, TH.,Liu, JF.,Hou, WT.,Li, SJ.,...&Huang, HH .(2018).A unique hybrid-structured surface produced by rapid electrochemical anodization enhances bio-corrosion resistance and bone cell responses of beta-type Ti-24Nb-4Zr-8Sn alloy.SCIENTIFIC REPORTS,8,-.
MLA Liu, CF,et al."A unique hybrid-structured surface produced by rapid electrochemical anodization enhances bio-corrosion resistance and bone cell responses of beta-type Ti-24Nb-4Zr-8Sn alloy".SCIENTIFIC REPORTS 8(2018):-.
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