Fabrication of open-cellular (porous) titanium alloy implants: osseointegration, vascularization and preliminary human trials

IMR OpenIR

	Fabrication of open-cellular (porous) titanium alloy implants: osseointegration, vascularization and preliminary human trials
	Li, SJ; Li, XK; Hou, WT; Nune, KC; Misra, RDK; Correa-Rodriguez, VL; Guo, Z; Hao, YL; Yang, R; Murr, LE; Guo, Z (reprint author), Fourth Mil Med Univ, Xijing Hosp, Dept Orthoped, Xian 710032, Shaanxi, Peoples R China.
	2018-04-01
发表期刊	SCIENCE CHINA-MATERIALS
ISSN	2095-8226
卷号	61 期号:4 页码:525-536
摘要	In this study we describe the fabrication of a variety of open-cellular titanium alloy (Ti-6Al-4V) implants, both reticular mesh and foam structures, using electron beam melting (EBM). These structures allow for the elimination of stress shielding by adjusting the porosity (or density) to produce an elastic modulus (or stiffness) to match that of both soft (trabecular) and hard (cortical) bone, as well as allowing for bone cell ingrowth, increased cell density, and all-matrix interactions; the latter involving the interplay between bone morphogenetic protein (BMP-2) and osteoblast functions. The early formation and characterization of elementary vascular structures in an aqueous hydrogel matrix are illustrated. Preliminary results for both animal (sheep) and human trials for a number of EBM-fabricated, and often patient-specific Ti-alloy implants are also presented and summarized. The results, while preliminary, support the concept and development of successful, porous, engineered "living" implants.; In this study we describe the fabrication of a variety of open-cellular titanium alloy (Ti-6Al-4V) implants, both reticular mesh and foam structures, using electron beam melting (EBM). These structures allow for the elimination of stress shielding by adjusting the porosity (or density) to produce an elastic modulus (or stiffness) to match that of both soft (trabecular) and hard (cortical) bone, as well as allowing for bone cell ingrowth, increased cell density, and all-matrix interactions; the latter involving the interplay between bone morphogenetic protein (BMP-2) and osteoblast functions. The early formation and characterization of elementary vascular structures in an aqueous hydrogel matrix are illustrated. Preliminary results for both animal (sheep) and human trials for a number of EBM-fabricated, and often patient-specific Ti-alloy implants are also presented and summarized. The results, while preliminary, support the concept and development of successful, porous, engineered "living" implants.
部门归属	[li, shujun ; hou, wentao ; hao, yulin ; yang, rui] chinese acad sci, inst met res, shenyang natl lab mat sci, shenyang 110016, liaoning, peoples r china ; [li, xiaokang ; guo, zheng] fourth mil med univ, xijing hosp, dept orthoped, xian 710032, shaanxi, peoples r china ; [nune, krishna c. ; misra, r. devesh k. ; correa-rodriguez, victor l. ; murr, lawrence e.] univ texas el paso, dept met mat & biomed engn, el paso, tx 79968 usa
关键词	Next-generation Mesh Arrays In-vivo Bone Scaffolds Angiogenesis Osteogenesis Technologies Constructs Interplay
学科领域	Materials Science, Multidisciplinary
资助者	Ministry of Science and Technology [2017YFC1104900, 2016YFC1102601]; National Natural Science Foundation of China [51271182, 51631007]; Chinese Academy of Sciences [QYZDJ-SSW-JSC031]; Department of Metallurgical, Materials and Biomedical Engineering; Office of Research and Sponsored Projects at the University of Texas at El Paso
收录类别	SCI
语种	英语
WOS记录号	WOS:000432685300007
引用统计	被引频次：42[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/79381
专题	中国科学院金属研究所
通讯作者	Guo, Z (reprint author), Fourth Mil Med Univ, Xijing Hosp, Dept Orthoped, Xian 710032, Shaanxi, Peoples R China.
推荐引用方式 GB/T 7714	Li, SJ,Li, XK,Hou, WT,et al. Fabrication of open-cellular (porous) titanium alloy implants: osseointegration, vascularization and preliminary human trials[J]. SCIENCE CHINA-MATERIALS,2018,61(4):525-536.
APA	Li, SJ.,Li, XK.,Hou, WT.,Nune, KC.,Misra, RDK.,...&Guo, Z .(2018).Fabrication of open-cellular (porous) titanium alloy implants: osseointegration, vascularization and preliminary human trials.SCIENCE CHINA-MATERIALS,61(4),525-536.
MLA	Li, SJ,et al."Fabrication of open-cellular (porous) titanium alloy implants: osseointegration, vascularization and preliminary human trials".SCIENCE CHINA-MATERIALS 61.4(2018):525-536.