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Fabrication of open-cellular (porous) titanium alloy implants: osseointegration, vascularization and preliminary human trials
Li, SJ; Li, XK; Hou, WT; Nune, KC; Misra, RDK; Correa-Rodriguez, VL; Guo, Z; Hao, YL; Yang, R; Murr, LE; Guo, Z (reprint author), Fourth Mil Med Univ, Xijing Hosp, Dept Orthoped, Xian 710032, Shaanxi, Peoples R China.
2018-04-01
Source PublicationSCIENCE CHINA-MATERIALS
ISSN2095-8226
Volume61Issue:4Pages:525-536
AbstractIn this study we describe the fabrication of a variety of open-cellular titanium alloy (Ti-6Al-4V) implants, both reticular mesh and foam structures, using electron beam melting (EBM). These structures allow for the elimination of stress shielding by adjusting the porosity (or density) to produce an elastic modulus (or stiffness) to match that of both soft (trabecular) and hard (cortical) bone, as well as allowing for bone cell ingrowth, increased cell density, and all-matrix interactions; the latter involving the interplay between bone morphogenetic protein (BMP-2) and osteoblast functions. The early formation and characterization of elementary vascular structures in an aqueous hydrogel matrix are illustrated. Preliminary results for both animal (sheep) and human trials for a number of EBM-fabricated, and often patient-specific Ti-alloy implants are also presented and summarized. The results, while preliminary, support the concept and development of successful, porous, engineered "living" implants.; In this study we describe the fabrication of a variety of open-cellular titanium alloy (Ti-6Al-4V) implants, both reticular mesh and foam structures, using electron beam melting (EBM). These structures allow for the elimination of stress shielding by adjusting the porosity (or density) to produce an elastic modulus (or stiffness) to match that of both soft (trabecular) and hard (cortical) bone, as well as allowing for bone cell ingrowth, increased cell density, and all-matrix interactions; the latter involving the interplay between bone morphogenetic protein (BMP-2) and osteoblast functions. The early formation and characterization of elementary vascular structures in an aqueous hydrogel matrix are illustrated. Preliminary results for both animal (sheep) and human trials for a number of EBM-fabricated, and often patient-specific Ti-alloy implants are also presented and summarized. The results, while preliminary, support the concept and development of successful, porous, engineered "living" implants.
description.department[li, shujun ; hou, wentao ; hao, yulin ; yang, rui] chinese acad sci, inst met res, shenyang natl lab mat sci, shenyang 110016, liaoning, peoples r china ; [li, xiaokang ; guo, zheng] fourth mil med univ, xijing hosp, dept orthoped, xian 710032, shaanxi, peoples r china ; [nune, krishna c. ; misra, r. devesh k. ; correa-rodriguez, victor l. ; murr, lawrence e.] univ texas el paso, dept met mat & biomed engn, el paso, tx 79968 usa
KeywordNext-generation Mesh Arrays In-vivo Bone Scaffolds Angiogenesis Osteogenesis Technologies Constructs Interplay
Subject AreaMaterials Science, Multidisciplinary
Funding OrganizationMinistry of Science and Technology [2017YFC1104900, 2016YFC1102601]; National Natural Science Foundation of China [51271182, 51631007]; Chinese Academy of Sciences [QYZDJ-SSW-JSC031]; Department of Metallurgical, Materials and Biomedical Engineering; Office of Research and Sponsored Projects at the University of Texas at El Paso
Indexed BySCI
Language英语
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/79381
Collection中国科学院金属研究所
Corresponding AuthorGuo, Z (reprint author), Fourth Mil Med Univ, Xijing Hosp, Dept Orthoped, Xian 710032, Shaanxi, Peoples R China.
Recommended Citation
GB/T 7714
Li, SJ,Li, XK,Hou, WT,et al. Fabrication of open-cellular (porous) titanium alloy implants: osseointegration, vascularization and preliminary human trials[J]. SCIENCE CHINA-MATERIALS,2018,61(4):525-536.
APA Li, SJ.,Li, XK.,Hou, WT.,Nune, KC.,Misra, RDK.,...&Guo, Z .(2018).Fabrication of open-cellular (porous) titanium alloy implants: osseointegration, vascularization and preliminary human trials.SCIENCE CHINA-MATERIALS,61(4),525-536.
MLA Li, SJ,et al."Fabrication of open-cellular (porous) titanium alloy implants: osseointegration, vascularization and preliminary human trials".SCIENCE CHINA-MATERIALS 61.4(2018):525-536.
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