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Effects of scandium addition on biocompatibility of biodegradable Mg-1.5Zn-0.6Zr alloy
Li, T; He, Y; Zhou, JX; Tang, SQ; Yang, YS; Wang, XT; Li, T (reprint author), Shandong Acad Sci, Adv Mat Inst, Shandong Key Lab High Strength Lightweight Metall, Jinan 250014, Shandong, Peoples R China.; Wang, XT (reprint author), Univ Sci & Technol Beijing, Collaborat Innovat Ctr Steel Technol, Beijing 100083, Peoples R China.
2018-03-15
Source PublicationMATERIALS LETTERS
ISSN0167-577X
Volume215Pages:200-202
AbstractHeretofore, the effects of scandium on the biocompatibility of biodegradable magnesium alloys are extremely limited recognized. In the present study, four Mg-1.5Zn-0.6Zr-xSc (x = 0, 0.2, 0.5, 1.0 wt%) alloys were fabricated and their hydrophilicity, cytotoxicity, and hemocompatibility were investigated. The contact angle measurements revealed that addition of Sc improved the hydrophilicity of the alloys. For biodegradable alloys, perfect hydrophilicity could promote the tissue attaching on implant surface, establishing a benign biological reaction and improving the therapeutic effectiveness. The viabilities of L-929 cells and SP2/0 cells for all the alloys were about 100% and 90% compared to negative control, respectively. No obvious differences existed in cell viabilities between different Sc contents. With increasing addition of Sc, the hemolysis percentages and the degree of platelet activation increased. It deteriorated the hemocompatibility of the alloys. Proteomics, genomics, and in vivo investigations are needed in the future to get more deep understandings of the biocompatibility of Sc. (C) 2017 Elsevier B.V. All rights reserved.; Heretofore, the effects of scandium on the biocompatibility of biodegradable magnesium alloys are extremely limited recognized. In the present study, four Mg-1.5Zn-0.6Zr-xSc (x = 0, 0.2, 0.5, 1.0 wt%) alloys were fabricated and their hydrophilicity, cytotoxicity, and hemocompatibility were investigated. The contact angle measurements revealed that addition of Sc improved the hydrophilicity of the alloys. For biodegradable alloys, perfect hydrophilicity could promote the tissue attaching on implant surface, establishing a benign biological reaction and improving the therapeutic effectiveness. The viabilities of L-929 cells and SP2/0 cells for all the alloys were about 100% and 90% compared to negative control, respectively. No obvious differences existed in cell viabilities between different Sc contents. With increasing addition of Sc, the hemolysis percentages and the degree of platelet activation increased. It deteriorated the hemocompatibility of the alloys. Proteomics, genomics, and in vivo investigations are needed in the future to get more deep understandings of the biocompatibility of Sc. (C) 2017 Elsevier B.V. All rights reserved.
description.department[li, tao ; zhou, jixue ; tang, shouqiu ; yang, yuansheng] shandong acad sci, adv mat inst, shandong key lab high strength lightweight metall, jinan 250014, shandong, peoples r china ; [li, tao ; yang, yuansheng] chinese acad sci, inst met res, shenyang 110016, liaoning, peoples r china ; [li, tao ; he, yong] univ sci & technol beijing, state key lab adv met & mat, beijing 100083, peoples r china ; [wang, xitao] univ sci & technol beijing, collaborat innovat ctr steel technol, beijing 100083, peoples r china
KeywordRare-earth-elements In-vitro Degradation Magnesium Alloys Cell-lines Corrosion Behavior Microstructure Implants Metals
Subject AreaMaterials Science, Multidisciplinary ; Physics, Applied
Funding OrganizationNational Natural Science Foundation of China [51174025]; National Key Research and Development Program of China [2016YFB0301105]; Shandong Academy of Sciences of China [2018QN0034]; Shandong Provincial Natural Science Foundation of China [ZR2017LEM002]
Indexed BySCI
Language英语
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/79428
Collection中国科学院金属研究所
Corresponding AuthorLi, T (reprint author), Shandong Acad Sci, Adv Mat Inst, Shandong Key Lab High Strength Lightweight Metall, Jinan 250014, Shandong, Peoples R China.; Wang, XT (reprint author), Univ Sci & Technol Beijing, Collaborat Innovat Ctr Steel Technol, Beijing 100083, Peoples R China.
Recommended Citation
GB/T 7714
Li, T,He, Y,Zhou, JX,et al. Effects of scandium addition on biocompatibility of biodegradable Mg-1.5Zn-0.6Zr alloy[J]. MATERIALS LETTERS,2018,215:200-202.
APA Li, T.,He, Y.,Zhou, JX.,Tang, SQ.,Yang, YS.,...&Wang, XT .(2018).Effects of scandium addition on biocompatibility of biodegradable Mg-1.5Zn-0.6Zr alloy.MATERIALS LETTERS,215,200-202.
MLA Li, T,et al."Effects of scandium addition on biocompatibility of biodegradable Mg-1.5Zn-0.6Zr alloy".MATERIALS LETTERS 215(2018):200-202.
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