In Vivo Effect of Titanium Implants with Porous Zinc-Containing Coatings Prepared by Plasma Electrolytic Oxidation Method on Osseointegration in Rabbits

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	In Vivo Effect of Titanium Implants with Porous Zinc-Containing Coatings Prepared by Plasma Electrolytic Oxidation Method on Osseointegration in Rabbits
	He, J; Feng, W; Zhao, BH; Zhang, W; Lin, Z; Zhao, BH (reprint author), China Med Univ, Sch Stomatol, Ctr Implant Dent, Nanjing North St 117, Shenyang 110002, Liaoning, Peoples R China.; Zhang, W (reprint author), Chinese Acad Sci, Inst Met Res, Shenyang 110016, Liaoning, Peoples R China.
	2018
发表期刊	INTERNATIONAL JOURNAL OF ORAL & MAXILLOFACIAL IMPLANTS
ISSN	0882-2786
卷号	33 期号:2 页码:298-310
摘要	Purpose: The aim of this study was to confirm the in vivo effect of surface-modified titanium (Ti) implants with zinc (Zn) prepared by a plasma electrolytic oxidation (PEO) method on the process of osseointegration. Materials and Methods: Forty-five New Zealand white rabbits were used. Implants were divided into three groups due to different surface treatments (the PEO-Zn group, the PEO-calcium phosphorus [Ca/P] group, and the sandblasted [control] group) and were randomly inserted into rabbits' mandibles. The implant surface morphology and chemical state of the relevant elements were observed. The maximum push-out force, the bone-to-implant contact (BIC), and the mineral apposition ratio (MAR) were detected at 4, 8, and 12 weeks after implantation. Results: A two-layer structure, with a dense inner layer and a porous outer layer, was found in the PEO samples. In the PEO-Zn group, CaHPO4 center dot 2H(2)O (dicalcium phosphate dihydrate) was the main calcium compound, and ZnO was identified as the predominant form of Zn. More bone deposition was found on the top of the PEO-Zn implant, which was also confirmed by scanning electron microscope (SEM) afterward, and the shear strength reached a maximum value of 1.57 +/- 0.26 MPa at 12 weeks compared with the sandblasted group and the PEO-Ca/P group. The BIC values and the MARs of the PEO-Zn group were significantly higher than the control group, especially at the early weeks (P < .05), and first reached maximum values of 73.91% +/- 9.01% and 4.89 +/- 0.60 mu m/d at 12 weeks, respectively. Conclusion: Implants with Zn coating by the PEO method could accelerate bone formation and bone remodeling, shorten the osseointegration period, and enhance bone-implant bonding force.; Purpose: The aim of this study was to confirm the in vivo effect of surface-modified titanium (Ti) implants with zinc (Zn) prepared by a plasma electrolytic oxidation (PEO) method on the process of osseointegration. Materials and Methods: Forty-five New Zealand white rabbits were used. Implants were divided into three groups due to different surface treatments (the PEO-Zn group, the PEO-calcium phosphorus [Ca/P] group, and the sandblasted [control] group) and were randomly inserted into rabbits' mandibles. The implant surface morphology and chemical state of the relevant elements were observed. The maximum push-out force, the bone-to-implant contact (BIC), and the mineral apposition ratio (MAR) were detected at 4, 8, and 12 weeks after implantation. Results: A two-layer structure, with a dense inner layer and a porous outer layer, was found in the PEO samples. In the PEO-Zn group, CaHPO4 center dot 2H(2)O (dicalcium phosphate dihydrate) was the main calcium compound, and ZnO was identified as the predominant form of Zn. More bone deposition was found on the top of the PEO-Zn implant, which was also confirmed by scanning electron microscope (SEM) afterward, and the shear strength reached a maximum value of 1.57 +/- 0.26 MPa at 12 weeks compared with the sandblasted group and the PEO-Ca/P group. The BIC values and the MARs of the PEO-Zn group were significantly higher than the control group, especially at the early weeks (P < .05), and first reached maximum values of 73.91% +/- 9.01% and 4.89 +/- 0.60 mu m/d at 12 weeks, respectively. Conclusion: Implants with Zn coating by the PEO method could accelerate bone formation and bone remodeling, shorten the osseointegration period, and enhance bone-implant bonding force.
部门归属	[he, jing ; zhao, bao-hong] china med univ, sch stomatol, ctr implant dent, nanjing north st 117, shenyang 110002, liaoning, peoples r china ; [feng, wei] jining med univ, affiliated hosp, dept oral implants, jining, peoples r china ; [zhang, wei] chinese acad sci, inst met res, shenyang natl lab mat sci, corros & protect div, shenyang, liaoning, peoples r china ; [zhang, wei] jilin normal univ, minist educ, key lab preparat & applicat environm friendly mat, changchun, jilin, peoples r china ; [lin, zeng] northeastern univ, sch mech engn & automat, shenyang, liaoning, peoples r china
关键词	Calcium-phosphate Cement Promoting Bone-formation Blood Mononuclear-cells Micro-arc Oxidation Tricalcium Phosphate Corrosion Behavior Pure Titanium Surface Hydroxyapatite Brushite
学科领域	Dentistry, Oral Surgery & Medicine
资助者	Nature Sciences Foundation of Liaoning Province of China [20092093, 2013225049]; Nature Sciences Foundation of Shenyang of China [F11-264-1-25]; Open Project Program of Key Laboratory of Preparation and Application of Environmental Friendly Materials (Jilin Normal University), Ministry of Education, China [2017002]
收录类别	SCI
语种	英语
WOS记录号	WOS:000427282400008
引用统计	被引频次：26[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/79457
专题	中国科学院金属研究所
通讯作者	Zhao, BH (reprint author), China Med Univ, Sch Stomatol, Ctr Implant Dent, Nanjing North St 117, Shenyang 110002, Liaoning, Peoples R China.; Zhang, W (reprint author), Chinese Acad Sci, Inst Met Res, Shenyang 110016, Liaoning, Peoples R China.
推荐引用方式 GB/T 7714	He, J,Feng, W,Zhao, BH,et al. In Vivo Effect of Titanium Implants with Porous Zinc-Containing Coatings Prepared by Plasma Electrolytic Oxidation Method on Osseointegration in Rabbits[J]. INTERNATIONAL JOURNAL OF ORAL & MAXILLOFACIAL IMPLANTS,2018,33(2):298-310.
APA	He, J.,Feng, W.,Zhao, BH.,Zhang, W.,Lin, Z.,...&Zhang, W .(2018).In Vivo Effect of Titanium Implants with Porous Zinc-Containing Coatings Prepared by Plasma Electrolytic Oxidation Method on Osseointegration in Rabbits.INTERNATIONAL JOURNAL OF ORAL & MAXILLOFACIAL IMPLANTS,33(2),298-310.
MLA	He, J,et al."In Vivo Effect of Titanium Implants with Porous Zinc-Containing Coatings Prepared by Plasma Electrolytic Oxidation Method on Osseointegration in Rabbits".INTERNATIONAL JOURNAL OF ORAL & MAXILLOFACIAL IMPLANTS 33.2(2018):298-310.