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In vitro study of stimulation effect on endothelialization by a copper bearing cobalt alloy
Jin, SJ; Qi, X; Wang, TM; Ren, L; Yang, K; Zhong, HS; Ren, L (reprint author), Chinese Acad Sci, Inst Met Res, 72 Wenhua Rd, Shenyang 110016, Peoples R China.
2018-02-01
发表期刊JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
ISSN1549-3296
卷号106期号:2页码:561-569
摘要Endothelialization is an important process after stenting in coronary artery. Recovery of the injured site timely can reduce the neointima formation and platelet absorbance, leading to a lower risk of in-stent restenosis. Copper is known to be critical in vascular construction. Thus a combination of copper with stent materials is a meaningful attempt. A copper bearing L605-Cu cobalt alloy was prepared and its effect on human umbilical vein endothelial cells (HUVECs) was evaluated in vitro in this study. It was found that HUVECs attached and stretched better on the surface of L605-Cu compared with L605, and the apoptosis of cells was decreased simultaneously. The migration and tube formation of HUVECs were also enhanced by the extract of L605-Cu. Furthermore, L605-Cu increased the mRNA expression of VEGF in HUVECs significantly. However it had no effect on the secretion of NO or mRNA expression of eNOS. The result of blood clotting test indicated that L605-Cu had better blood compatibility. These results above have demonstrated that the L605-Cu alloy is promising to be a new stent material with function of accelerating endothelialization. (c) 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 561-569, 2018.; Endothelialization is an important process after stenting in coronary artery. Recovery of the injured site timely can reduce the neointima formation and platelet absorbance, leading to a lower risk of in-stent restenosis. Copper is known to be critical in vascular construction. Thus a combination of copper with stent materials is a meaningful attempt. A copper bearing L605-Cu cobalt alloy was prepared and its effect on human umbilical vein endothelial cells (HUVECs) was evaluated in vitro in this study. It was found that HUVECs attached and stretched better on the surface of L605-Cu compared with L605, and the apoptosis of cells was decreased simultaneously. The migration and tube formation of HUVECs were also enhanced by the extract of L605-Cu. Furthermore, L605-Cu increased the mRNA expression of VEGF in HUVECs significantly. However it had no effect on the secretion of NO or mRNA expression of eNOS. The result of blood clotting test indicated that L605-Cu had better blood compatibility. These results above have demonstrated that the L605-Cu alloy is promising to be a new stent material with function of accelerating endothelialization. (c) 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 561-569, 2018.
部门归属[jin, shujing ; wang, tongmin] dalian univ technol, sch mat sci & engn, dalian 116024, peoples r china ; [jin, shujing ; ren, ling ; yang, ke] chinese acad sci, inst met res, 72 wenhua rd, shenyang 110016, peoples r china ; [qi, xun ; zhong, hongshan] china med univ, dept radiol, affiliated hosp 1, shenyang 110001, peoples r china ; [qi, xun ; zhong, hongshan] china med univ, key lab diagnost imaging & intervent radiol liaon, affiliated hosp 1, shenyang 110001, peoples r china
关键词Stent Restenosis Angiogenesis Cells Expression Release
学科领域Engineering, Biomedical ; Materials Science, bioMaterials
资助者National Natural Science Foundation [81301329, 81571778, 81201168]; Joint foundation of Liaoning Province Natural Science Foundation and Shenyang National Laboratory for materials science [2015021004]; Youth Innovation Promotion Association, CAS [2014168]; Natural Science Foundation of Guangdong province [2015A030312004]; Natural Science Foundation of Liaoning Province [201602850]
收录类别SCI
语种英语
文献类型期刊论文
条目标识符http://ir.imr.ac.cn/handle/321006/79556
专题中国科学院金属研究所
通讯作者Ren, L (reprint author), Chinese Acad Sci, Inst Met Res, 72 Wenhua Rd, Shenyang 110016, Peoples R China.
推荐引用方式
GB/T 7714
Jin, SJ,Qi, X,Wang, TM,et al. In vitro study of stimulation effect on endothelialization by a copper bearing cobalt alloy[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,2018,106(2):561-569.
APA Jin, SJ.,Qi, X.,Wang, TM.,Ren, L.,Yang, K.,...&Ren, L .(2018).In vitro study of stimulation effect on endothelialization by a copper bearing cobalt alloy.JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,106(2),561-569.
MLA Jin, SJ,et al."In vitro study of stimulation effect on endothelialization by a copper bearing cobalt alloy".JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A 106.2(2018):561-569.
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