IMR OpenIR
In vitro study of stimulation effect on endothelialization by a copper bearing cobalt alloy
Jin, SJ; Qi, X; Wang, TM; Ren, L; Yang, K; Zhong, HS; Ren, L (reprint author), Chinese Acad Sci, Inst Met Res, 72 Wenhua Rd, Shenyang 110016, Peoples R China.
2018-02-01
Source PublicationJOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
ISSN1549-3296
Volume106Issue:2Pages:561-569
AbstractEndothelialization is an important process after stenting in coronary artery. Recovery of the injured site timely can reduce the neointima formation and platelet absorbance, leading to a lower risk of in-stent restenosis. Copper is known to be critical in vascular construction. Thus a combination of copper with stent materials is a meaningful attempt. A copper bearing L605-Cu cobalt alloy was prepared and its effect on human umbilical vein endothelial cells (HUVECs) was evaluated in vitro in this study. It was found that HUVECs attached and stretched better on the surface of L605-Cu compared with L605, and the apoptosis of cells was decreased simultaneously. The migration and tube formation of HUVECs were also enhanced by the extract of L605-Cu. Furthermore, L605-Cu increased the mRNA expression of VEGF in HUVECs significantly. However it had no effect on the secretion of NO or mRNA expression of eNOS. The result of blood clotting test indicated that L605-Cu had better blood compatibility. These results above have demonstrated that the L605-Cu alloy is promising to be a new stent material with function of accelerating endothelialization. (c) 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 561-569, 2018.; Endothelialization is an important process after stenting in coronary artery. Recovery of the injured site timely can reduce the neointima formation and platelet absorbance, leading to a lower risk of in-stent restenosis. Copper is known to be critical in vascular construction. Thus a combination of copper with stent materials is a meaningful attempt. A copper bearing L605-Cu cobalt alloy was prepared and its effect on human umbilical vein endothelial cells (HUVECs) was evaluated in vitro in this study. It was found that HUVECs attached and stretched better on the surface of L605-Cu compared with L605, and the apoptosis of cells was decreased simultaneously. The migration and tube formation of HUVECs were also enhanced by the extract of L605-Cu. Furthermore, L605-Cu increased the mRNA expression of VEGF in HUVECs significantly. However it had no effect on the secretion of NO or mRNA expression of eNOS. The result of blood clotting test indicated that L605-Cu had better blood compatibility. These results above have demonstrated that the L605-Cu alloy is promising to be a new stent material with function of accelerating endothelialization. (c) 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 561-569, 2018.
description.department[jin, shujing ; wang, tongmin] dalian univ technol, sch mat sci & engn, dalian 116024, peoples r china ; [jin, shujing ; ren, ling ; yang, ke] chinese acad sci, inst met res, 72 wenhua rd, shenyang 110016, peoples r china ; [qi, xun ; zhong, hongshan] china med univ, dept radiol, affiliated hosp 1, shenyang 110001, peoples r china ; [qi, xun ; zhong, hongshan] china med univ, key lab diagnost imaging & intervent radiol liaon, affiliated hosp 1, shenyang 110001, peoples r china
KeywordStent Restenosis Angiogenesis Cells Expression Release
Subject AreaEngineering, Biomedical ; Materials Science, bioMaterials
Funding OrganizationNational Natural Science Foundation [81301329, 81571778, 81201168]; Joint foundation of Liaoning Province Natural Science Foundation and Shenyang National Laboratory for materials science [2015021004]; Youth Innovation Promotion Association, CAS [2014168]; Natural Science Foundation of Guangdong province [2015A030312004]; Natural Science Foundation of Liaoning Province [201602850]
Indexed BySCI
Language英语
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/79556
Collection中国科学院金属研究所
Corresponding AuthorRen, L (reprint author), Chinese Acad Sci, Inst Met Res, 72 Wenhua Rd, Shenyang 110016, Peoples R China.
Recommended Citation
GB/T 7714
Jin, SJ,Qi, X,Wang, TM,et al. In vitro study of stimulation effect on endothelialization by a copper bearing cobalt alloy[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,2018,106(2):561-569.
APA Jin, SJ.,Qi, X.,Wang, TM.,Ren, L.,Yang, K.,...&Ren, L .(2018).In vitro study of stimulation effect on endothelialization by a copper bearing cobalt alloy.JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,106(2),561-569.
MLA Jin, SJ,et al."In vitro study of stimulation effect on endothelialization by a copper bearing cobalt alloy".JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A 106.2(2018):561-569.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Jin, SJ]'s Articles
[Qi, X]'s Articles
[Wang, TM]'s Articles
Baidu academic
Similar articles in Baidu academic
[Jin, SJ]'s Articles
[Qi, X]'s Articles
[Wang, TM]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Jin, SJ]'s Articles
[Qi, X]'s Articles
[Wang, TM]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.