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In vitro and in vivo studies on the biodegradable behavior and bone response of Mg69Zn27Ca4 metal glass for treatment of bone defect | |
Chen, Junxiu; Dong, Jiahui; Fu, Huameng; Zhang, Haifeng; Tan, Lili; Zhao, Dewei; Yang, Ke | |
2019-10-01 | |
Source Publication | JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
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ISSN | 1005-0302 |
Volume | 35Issue:10Pages:2254-2262 |
Abstract | In the present work, the biodegradable behavior, cytocompatibility and osteogenesis activity of a Mg69Zn27Ca4 metal glass were investigated. Electrochemical test, immersion test, cytotoxicity test and histopathological evaluation were carried out. The results showed that there was a dense protective layer formed on the surface of Mg69Zn27Ca4 metal glass which could inhibit the degradation process in the Hank's solution. In vitro cytotoxicity test showed that Mg(69)Zn(27)Ca(4 )metal glass had good biocompatibility. Histopathological evaluation showed that the degradation of Mg69Zn27Ca4 metal glass could promote the new bone formation with no obvious inflammatory reactions. After 2 months implantation, the diameter of the bone defect was reduced from the original phi 6 mm to phi 3.35 +/- 0.40 mm with the degradation of Mg69Zn27Ca4 metal glass. Therefore, it can be concluded that Mg69Zn27Ca4 glass has great potential to be used as bone substitutes. (C) 2019 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science & Technology. |
Keyword | Mg69Zn27Ca4 metal glass Degradation Cytocompatibility Bone substitutes |
Indexed By | SCI |
Language | 英语 |
WOS ID | WOS:000484531600019 |
Publisher | JOURNAL MATER SCI TECHNOL |
Citation statistics | |
Document Type | 期刊论文 |
Identifier | http://ir.imr.ac.cn/handle/321006/80739 |
Collection | 中国科学院金属研究所 |
Recommended Citation GB/T 7714 | Chen, Junxiu,Dong, Jiahui,Fu, Huameng,et al. In vitro and in vivo studies on the biodegradable behavior and bone response of Mg69Zn27Ca4 metal glass for treatment of bone defect[J]. JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,2019,35(10):2254-2262. |
APA | Chen, Junxiu.,Dong, Jiahui.,Fu, Huameng.,Zhang, Haifeng.,Tan, Lili.,...&Yang, Ke.(2019).In vitro and in vivo studies on the biodegradable behavior and bone response of Mg69Zn27Ca4 metal glass for treatment of bone defect.JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,35(10),2254-2262. |
MLA | Chen, Junxiu,et al."In vitro and in vivo studies on the biodegradable behavior and bone response of Mg69Zn27Ca4 metal glass for treatment of bone defect".JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY 35.10(2019):2254-2262. |
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