In vitro and in vivo studies on the biodegradable behavior and bone response of Mg69Zn27Ca4 metal glass for treatment of bone defect

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	In vitro and in vivo studies on the biodegradable behavior and bone response of Mg69Zn27Ca4 metal glass for treatment of bone defect
	Chen, Junxiu; Dong, Jiahui; Fu, Huameng; Zhang, Haifeng; Tan, Lili; Zhao, Dewei; Yang, Ke
	2019-10-01
Source Publication	JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
ISSN	1005-0302
Volume	35 Issue:10 Pages:2254-2262
Abstract	In the present work, the biodegradable behavior, cytocompatibility and osteogenesis activity of a Mg69Zn27Ca4 metal glass were investigated. Electrochemical test, immersion test, cytotoxicity test and histopathological evaluation were carried out. The results showed that there was a dense protective layer formed on the surface of Mg69Zn27Ca4 metal glass which could inhibit the degradation process in the Hank's solution. In vitro cytotoxicity test showed that Mg(69)Zn(27)Ca(4 )metal glass had good biocompatibility. Histopathological evaluation showed that the degradation of Mg69Zn27Ca4 metal glass could promote the new bone formation with no obvious inflammatory reactions. After 2 months implantation, the diameter of the bone defect was reduced from the original phi 6 mm to phi 3.35 +/- 0.40 mm with the degradation of Mg69Zn27Ca4 metal glass. Therefore, it can be concluded that Mg69Zn27Ca4 glass has great potential to be used as bone substitutes. (C) 2019 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science & Technology.
Keyword	Mg69Zn27Ca4 metal glass Degradation Cytocompatibility Bone substitutes
Indexed By	SCI
Language	英语
WOS ID	WOS:000484531600019
Publisher	JOURNAL MATER SCI TECHNOL
Citation statistics
Document Type	期刊论文
Identifier	http://ir.imr.ac.cn/handle/321006/80739
Collection	中国科学院金属研究所
Recommended Citation GB/T 7714	Chen, Junxiu,Dong, Jiahui,Fu, Huameng,et al. In vitro and in vivo studies on the biodegradable behavior and bone response of Mg69Zn27Ca4 metal glass for treatment of bone defect[J]. JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,2019,35(10):2254-2262.
APA	Chen, Junxiu.,Dong, Jiahui.,Fu, Huameng.,Zhang, Haifeng.,Tan, Lili.,...&Yang, Ke.(2019).In vitro and in vivo studies on the biodegradable behavior and bone response of Mg69Zn27Ca4 metal glass for treatment of bone defect.JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,35(10),2254-2262.
MLA	Chen, Junxiu,et al."In vitro and in vivo studies on the biodegradable behavior and bone response of Mg69Zn27Ca4 metal glass for treatment of bone defect".JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY 35.10(2019):2254-2262.

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