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In vitro and in vivo characterization of novel calcium phosphate and magnesium (CaP-Mg) bilayer coated titanium for implantation
Chen, Lanyue; Yan, Xudong; Tan, Lili; Zheng, Bowen; Muhammed, Fenik Kaml; Yang, Ke; Liu, Yi
2019-09-25
Source PublicationSURFACE & COATINGS TECHNOLOGY
ISSN0257-8972
Volume374Pages:784-796
AbstractA novel bio-functional calcium phosphate and magnesium (CaP-Mg) bilayer coating on titanium (Ti) was fabricated and characterized in vitro and in vivo. The bilayer coating was fabricated by biomimetic method and physical vapor deposition (PVD). The intermediate calcium phosphate (CaP) layer was mainly composed of octacalcium phosphate (OCP) and hydroxyapatite (HA). Compared to the single magnesium (Mg) coating, Mg layer on bilayer coating was thicker, coarser and porous. Immersion test and electrochemical test showed that the intermediate CaP layer could not decrease the degradation rate, however, inhibit detachment of Mg. The Mg coating delaminated from the single Mg coated sample following immersion for 1 day, while no obvious evidence of detachment was observed for the bilayer even after immersion for 14 days. In vitro antibacterial assays proved that the CaP-Mg coating strongly reduced the viability of Staphylococcus aureus and performed an about 90% antibacterial efficacy after 3 h incubation due to high alkalinity produced by the degradation of Mg. The bare Ti bar and coated Ti bar implants were implanted into New Zealand white rabbit lower jaws for 4 and 12 weeks, respectively. Cone beam computed tomography (CBCT), and Masson and hematoxyline-eosin (HE) staining showed CaP-Mg coated Ti bar promoted superior osteointegration after 4 and 12 weeks implantations.
KeywordBilayer coating Degradation behavior Antibacterial ability Osteoconductivity
Indexed BySCI
Language英语
WOS IDWOS:000486360000078
PublisherELSEVIER SCIENCE SA
Citation statistics
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/80759
Collection中国科学院金属研究所
Recommended Citation
GB/T 7714
Chen, Lanyue,Yan, Xudong,Tan, Lili,et al. In vitro and in vivo characterization of novel calcium phosphate and magnesium (CaP-Mg) bilayer coated titanium for implantation[J]. SURFACE & COATINGS TECHNOLOGY,2019,374:784-796.
APA Chen, Lanyue.,Yan, Xudong.,Tan, Lili.,Zheng, Bowen.,Muhammed, Fenik Kaml.,...&Liu, Yi.(2019).In vitro and in vivo characterization of novel calcium phosphate and magnesium (CaP-Mg) bilayer coated titanium for implantation.SURFACE & COATINGS TECHNOLOGY,374,784-796.
MLA Chen, Lanyue,et al."In vitro and in vivo characterization of novel calcium phosphate and magnesium (CaP-Mg) bilayer coated titanium for implantation".SURFACE & COATINGS TECHNOLOGY 374(2019):784-796.
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