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Fabrication and Characterization of Nanopillar-Like HA Coating on Porous Ti6Al4V Scaffold by a Combination of Alkali-Acid-Heat and Hydrothermal Treatments
Li, Jun-Lei; Wang, Shuai; Cao, Fang; Lin, Xiao; Wei, Xiao-Wei; Zhao, Zhen-Hua; Dou, Xiao-Jie; Yu, Wei-Ting; Yang, Ke; Zhao, De-Wei
2019-09-01
Source PublicationACTA METALLURGICA SINICA-ENGLISH LETTERS
ISSN1006-7191
Volume32Issue:9Pages:1075-1088
AbstractPorous titanium scaffold with suitable porous architecture exhibits enormous potentials for bone defect repairs. However, insufficient osteointegration and osteoinduction still remain to open as one of the major problems to achieve satisfactory therapeutic effect. To solve this problem, many studies have been carried out to improve the bioactivity of porous titanium scaffold by surface modifications. In this study, porous Ti6Al4V scaffolds were fabricated using additive manufacturing technique. Porous architectures were built up based on a diamond pore structure unit. Alkali-acid-heat (AH) treatment was applied to create a TiO2 layer on the porous Ti6Al4V scaffold (AH-porous Ti6Al4V). Subsequently, a hydrothermal treatment was employed to enable the formation of HA coating with nanopillar-like morphology on the alkali-acid-heat-treated surface (HT/AH-porous Ti6Al4V). The effects of surface modifications on apatite-forming ability, protein adsorption, cell attachment, cell proliferation and osteogenic gene expression were studied using apatite-forming ability test, protein adsorption assay and in vitro cell culture assay. It was found that the HT/AH-porous Ti6Al4V exhibited the highest apatite formation ability and best affinity to fibronectin and vitronectin. In vitro studies indicated that the mesenchymal stem cells (MSCs) cultured on the HT/AH-porous Ti6Al4V presented improved adhesion and differentiation compared with the porous Ti6Al4V and AH-porous Ti6Al4V.
KeywordAdditive manufacturing Biomaterials Porous titanium scaffold HA coating
Indexed BySCI
Language英语
WOS IDWOS:000477005900003
PublisherCHINESE ACAD SCIENCES, INST METAL RESEARCH
Citation statistics
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/80798
Collection中国科学院金属研究所
Recommended Citation
GB/T 7714
Li, Jun-Lei,Wang, Shuai,Cao, Fang,et al. Fabrication and Characterization of Nanopillar-Like HA Coating on Porous Ti6Al4V Scaffold by a Combination of Alkali-Acid-Heat and Hydrothermal Treatments[J]. ACTA METALLURGICA SINICA-ENGLISH LETTERS,2019,32(9):1075-1088.
APA Li, Jun-Lei.,Wang, Shuai.,Cao, Fang.,Lin, Xiao.,Wei, Xiao-Wei.,...&Zhao, De-Wei.(2019).Fabrication and Characterization of Nanopillar-Like HA Coating on Porous Ti6Al4V Scaffold by a Combination of Alkali-Acid-Heat and Hydrothermal Treatments.ACTA METALLURGICA SINICA-ENGLISH LETTERS,32(9),1075-1088.
MLA Li, Jun-Lei,et al."Fabrication and Characterization of Nanopillar-Like HA Coating on Porous Ti6Al4V Scaffold by a Combination of Alkali-Acid-Heat and Hydrothermal Treatments".ACTA METALLURGICA SINICA-ENGLISH LETTERS 32.9(2019):1075-1088.
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