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| In vitro study on cytocompatibility and osteogenesis ability of Ti-Cu alloy | |
| Liu, Rui; Ma, Zheng; Kolawole, Sharafadeen Kunle; Zeng, Lilan; Zhao, Ying; Ren, Ling; Yang, Ke | |
| 2019-07-01 | |
| Source Publication | JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
 |
| ISSN | 0957-4530 |
| Volume | 30Issue:7 |
| Abstract | Titanium implants easily suffer bacteria-related infections in clinic due to their inherent lack of self-protection ability. Therefore, a novel Ti-Cu alloy with good antibacterial activity has been developed as a new kind of implant material. This study focuses on a systematic evaluation of both cytocompatibility and osteogenesis activity of the Ti-Cu alloy in vitro. It was revealed that an addition of 5% Cu into pure Ti would not cause any negative effect on osteoblasts adhesion, proliferation and apoptosis cultured with Ti-Cu alloy. In addition, Ti-Cu alloy could significantly promote the osteogenic differentiation of MG 63 cells by upregulating the osteogenesis-related gene expressions including alkaline phosphatase (ALP), Collagen I (Colla I), osteopontin (OPN) and osteocalcin (OCN). These promising results suggest that the Ti-Cu alloy has great potential to be used as a multi-functional titanium implant for clinical applications. [GRAPHICS] |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000472211800003 |
| Publisher | SPRINGER |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/80945 |
| Collection | 中国科学院金属研究所 |
| Recommended Citation GB/T 7714 | Liu, Rui,Ma, Zheng,Kolawole, Sharafadeen Kunle,et al. In vitro study on cytocompatibility and osteogenesis ability of Ti-Cu alloy[J]. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE,2019,30(7). |
| APA | Liu, Rui.,Ma, Zheng.,Kolawole, Sharafadeen Kunle.,Zeng, Lilan.,Zhao, Ying.,...&Yang, Ke.(2019).In vitro study on cytocompatibility and osteogenesis ability of Ti-Cu alloy.JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE,30(7). |
| MLA | Liu, Rui,et al."In vitro study on cytocompatibility and osteogenesis ability of Ti-Cu alloy".JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE 30.7(2019). |
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