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Bone regeneration of hollow tubular magnesium-strontium scaffolds in critical-size segmental defects: Effect of surface coatings
Wang, W.; Nune, K. C.; Tan, L.; Zhang, N.; Dong, J.; Yan, J.; Misra, R. D. K.; Yang, K.
2019-07-01
Source PublicationMATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
ISSN0928-4931
Volume100Pages:297-307
AbstractSegmental defects are formidable challenges for orthopedic surgeons that are caused by large osseous defects such as open injury, comminuted fracture as well as other severe traumas and infection. Current treatment options have practical and clinical shortcomings, calling for innovative bone graft materials. This study is related to hollow tubular magnesium-strontium (Mg-Sr) alloy scaffolds with autologous morselized bone filled inside and three different coatings were individually applied on Mg-Sr scaffolds, respectively, to study the effects of degradation and bioactivity of the grafts on new bone growth. The optimal coating method was screened using immersion tests, cell proliferation and adhesion, alkaline phosphatase (ALP) assay in vitro, and 4 weeks' implantation in a critical-size segmental defect in vivo. More new bone formation was observed by radiographic tests and histology along the ulna defects, when magnesium scaffold grafts were implanted. Meanwhile, depression occurred for blank control group with only autologous morselized bone filled, because of rapid absorption rate of morselized bone during initial implantation. Therefore, biodegradable Mg-Sr alloy grafts showed their potential application in treating the critical-size segmental defects. As for different coating methods, CaP chemically deposited (CaP) coated sample showed least H-2 evolution in vivo, demonstrating highest corrosion resistance and relative stable interfaces, however, the least beneficial ion release meanwhile. Micro-arc oxidation coating (MAO) degraded faster comparing with CaP, while with the main composition of MgO. They both indicate insufficient bioactivity in bone formation. The results suggest superior combination of bioactive surface, beneficial ions release and appropriate corrosion rate of Strontium phosphate conversion (SrP) coating, indicating superior comprehensive oeteoconductive and osteoinductive properties of coatings on hollow tubular Mg-Sr alloy scaffold.
KeywordBiodegradable magnesium alloy Coating Scaffold Segmental defect Bone regeneration
Indexed BySCI
Language英语
WOS IDWOS:000466059700029
PublisherELSEVIER SCIENCE BV
Citation statistics
Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/80970
Collection中国科学院金属研究所
Recommended Citation
GB/T 7714
Wang, W.,Nune, K. C.,Tan, L.,et al. Bone regeneration of hollow tubular magnesium-strontium scaffolds in critical-size segmental defects: Effect of surface coatings[J]. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,2019,100:297-307.
APA Wang, W..,Nune, K. C..,Tan, L..,Zhang, N..,Dong, J..,...&Yang, K..(2019).Bone regeneration of hollow tubular magnesium-strontium scaffolds in critical-size segmental defects: Effect of surface coatings.MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,100,297-307.
MLA Wang, W.,et al."Bone regeneration of hollow tubular magnesium-strontium scaffolds in critical-size segmental defects: Effect of surface coatings".MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS 100(2019):297-307.
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