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Bioactive coating on a new Mg-2Zn-0.5Nd alloy: modulation of degradation rate and cellular response
Patil, Sachin S.; Misra, R. D. K.; Gao, M.; Ma, Z.; Tan, L.; Yang, K.
2019-06-07
Source PublicationMATERIALS TECHNOLOGY
ISSN1066-7857
Volume34Issue:7Pages:394-402
AbstractPure magnesium implants have a problem of faster degradation which leads to the collapse of the implant before the recovery of physiological organ. A new magnesium alloy viz Mg-2Zn-0.5Nd (ZN20) is designed using a well-known alloying method to decrease the degradation rate of pure magnesium metal and its implants so as to match the tissue recovery rate. MTT assay of the ZN20 alloy via a direct contact method for 2, 4 and 6 days using MC3T3-E1 cells showed cytotoxicity. Whereas, the MTT assay results of this alloy via ion-extract method showed non-cytotoxic behaviour. The degradation rate of ZN20 alloy in SBF was similar to 2.5% in 16 days which is comparable to the rate of regeneration and recovery of physiological tissue. The pH of the outer solution after degradation of ZN20 alloy for 3 days was around 9.31 +/- 0.05 which was higher than the initial pH of SBF used (pH 7.4). The reason for the cytotoxic behaviour of this alloy could be the increase in pH of immersion solution with the degradation of the alloy. Interestingly, the scanning electron microscope images followed by EDX spectrum of ZN20 alloy showed deposition of white crystalline mineralisation product (apatite) after 3, 7, 11 and 16 days of incubation in SBF at 37 degrees C. The FT-IR spectrum and X-ray chromatogram of the white substance confirmed the deposition of apatite (calcium phosphate) on their surfaces. These results concluded the bioactivity of ZN20 alloy and thus could be used as an implant material for regeneration of bones/tissues.
KeywordMagnesium alloy bioactivity calcium phosphate apatite metal implants
Indexed BySCI
Language英语
WOS IDWOS:000467883400004
PublisherTAYLOR & FRANCIS LTD
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/81007
Collection中国科学院金属研究所
Recommended Citation
GB/T 7714
Patil, Sachin S.,Misra, R. D. K.,Gao, M.,et al. Bioactive coating on a new Mg-2Zn-0.5Nd alloy: modulation of degradation rate and cellular response[J]. MATERIALS TECHNOLOGY,2019,34(7):394-402.
APA Patil, Sachin S.,Misra, R. D. K.,Gao, M.,Ma, Z.,Tan, L.,&Yang, K..(2019).Bioactive coating on a new Mg-2Zn-0.5Nd alloy: modulation of degradation rate and cellular response.MATERIALS TECHNOLOGY,34(7),394-402.
MLA Patil, Sachin S.,et al."Bioactive coating on a new Mg-2Zn-0.5Nd alloy: modulation of degradation rate and cellular response".MATERIALS TECHNOLOGY 34.7(2019):394-402.
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