| A Novel Injectable Magnesium/Calcium Sulfate Hemihydrate Composite Cement for Bone Regeneration | |
| Zhang, Shanchuan1,2; Yang, Ke3; Cui, Fuzhai4; Jiang, Yi5; E, Lingling2; Xu, Baohua1; Liu, Hongchen2 | |
| 通讯作者 | Xu, Baohua(baohuaxuu@163.com) |
| 2015 | |
| 发表期刊 | BIOMED RESEARCH INTERNATIONAL
 |
| ISSN | 2314-6133 |
| 页码 | 15 |
| 摘要 | Objective. A novel injectable magnesium/calcium sulfate hemihydrate (Mg/CSH) composite with improved properties was reported here. Methods. Composition, setting time, injectability, compressive strength, and bioactivity in simulated body fluid (SBF) of the Mg/CSH composite were evaluated. Furthermore, the cellular responses of canine bone marrow stromal cells (cBMSCs) and bone formation capacity after the implantation of Mg/CSH in tibia defects of canine were investigated. Results. Mg/CSH possessed a prolonged setting time and markedly improved injectability and mechanical property (p < 0.05). Mg/CSH samples showed better degradability than CSH in SBF after 21 days of soaking (p < 0.05). Moreover, the degrees of cell attachment, proliferation, and capability of osteogenic differentiation on the Mg/CSH specimens were higher than those on CSH, without significant cytotoxicity and with the increased proliferation index, ALP activity, and expression levels of integrin beta(1) and Coll I in cBMSCs (p < 0.05). Mg/CSH enhanced the efficiency of new bone formation at the tibia defect area, including the significantly elevated bone mineral density, bone area fraction, and Coll I expression level (p < 0.05). Conclusions. The results implied that this new injectable bone scaffold exhibited promising prospects for bone repair and had a great potential in bone tissue engineering. |
| 资助者 | State Natural Science Fund, China ; China Postdoctoral Science Foundation |
| DOI | 10.1155/2015/297437 |
| 收录类别 | SCI |
| 语种 | 英语 |
| 资助项目 | State Natural Science Fund, China[81200819] ; China Postdoctoral Science Foundation[2013T60943] ; China Postdoctoral Science Foundation[2012M512121] |
| WOS研究方向 | Biotechnology & Applied Microbiology ; Research & Experimental Medicine |
| WOS类目 | Biotechnology & Applied Microbiology ; Medicine, Research & Experimental |
| WOS记录号 | WOS:000356260400001 |
| 出版者 | HINDAWI PUBLISHING CORPORATION |
| 引用统计 | |
| 文献类型 | 期刊论文 |
| 条目标识符 | http://ir.imr.ac.cn/handle/321006/81198 |
| 通讯作者 | Xu, Baohua |
| 作者单位 | 1.China Japan Friendship Hosp, Ctr Stomatol, Beijing 100029, Peoples R China 2.Chinese Peoples Liberat Army Gen Hosp, Inst Stomatol, Beijing 100853, Peoples R China 3.Chinese Acad Sci, Inst Met Res, Specialized Mat & Devices Div, Shenyang 110016, Peoples R China 4.Tsinghua Univ, Adv Mat Lab, Beijing 100084, Peoples R China 5.Chinese Peoples Liberat Army Gen Hosp, Dept Geriatr Dent, Beijing 100853, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Shanchuan,Yang, Ke,Cui, Fuzhai,et al. A Novel Injectable Magnesium/Calcium Sulfate Hemihydrate Composite Cement for Bone Regeneration[J]. BIOMED RESEARCH INTERNATIONAL,2015:15. |
| APA | Zhang, Shanchuan.,Yang, Ke.,Cui, Fuzhai.,Jiang, Yi.,E, Lingling.,...&Liu, Hongchen.(2015).A Novel Injectable Magnesium/Calcium Sulfate Hemihydrate Composite Cement for Bone Regeneration.BIOMED RESEARCH INTERNATIONAL,15. |
| MLA | Zhang, Shanchuan,et al."A Novel Injectable Magnesium/Calcium Sulfate Hemihydrate Composite Cement for Bone Regeneration".BIOMED RESEARCH INTERNATIONAL (2015):15. |
| 条目包含的文件 | 条目无相关文件。 | |||||
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