IMR OpenIR
Surface degradation-enabled osseointegrative, angiogenic and antiinfective properties of magnesium-modified acrylic bone cement
Lin, Xiao; Ge, Jun; Wei, Donglei; Liu, Chun; Tan, Lili; Yang, Huilin; Yang, Ke; Zhou, Huan; Li, Bin; Luo, Zong-Ping; Yang, Lei
2019-04-01
Source PublicationJOURNAL OF ORTHOPAEDIC TRANSLATION
ISSN2214-031X
Volume17Pages:121-132
AbstractObjective: This work focuses on tackling the inadequate bone/implant interface strength of acrylic bone cements, which is a formidable problem diminishing their clinical performance, especially in percutaneous kyphoplasty surgery. Methods: A new strategy of incorporating magnesium particles into clinically used poly(methylmethacrylate) (PMMA) bone cement to prepare a surface-degradable bone cement (SdBC) is proposed and validated both in vitro and in vivo. Results: This surface degradation characteristic enables osseointegrative, angiogenic and anti-infective properties. SdBC showed fast surface degradation and formed porous surfaces as designed, while the desirable high compressive strengths (>= 70 MPa) of the cement were preserved. Besides, the SdBC with proper Mg content promoted osteoblast adhesion, spreading, proliferation and endothelial cell angiogenesis capacity compared with PMMA. Also, SdBC demonstrated clear inhibitory effect on Staphylococcus aureus and Escherichia coli. In vivo evaluation on SdBC by the rat femur defect model showed that the bone/implant interface strength was significantly enhanced in SdBC (push-out force of 11.8 +/- 1.5 N for SdBC vs 7.0 +/- 2.3N for PMMA), suggesting significantly improved osseointegration and bone growth induced by the surface degradation of the cement. The injectability, setting times and compressive strengths of SdBC with proper content of Mg particles (2.8 wt% and 5.4 wt%) were comparable with those of the clinical acrylic bone cement, while the heat release during polymerization was reduced (maximum temperature 78 +/- 1 degrees C for PMMA vs 73.3 +/- 1.5 degrees C for SdBC). Conclusions: This work validates a new concept of designing bioactive bone/implant interface in PMMA bone cement. And this surface-degradable bone cement possesses great potential for minimally invasive orthopaedic surgeries such as percutaneous kyphoplasty. The translational potential of this article: This work reports PMMA/Mg surface-degradable acrylic bone cements that possess enhanced osseointegrative, angiogenic and antiinfective properties that are lacking in the clinically used acrylic bone cements. This new kind of bone cements could improve the treatment outcome of many orthopaedic surgeries such as percutaneous kyphoplasty and arthroplasty. (C) 2019 The Authors. Published by Elsevier (Singapore) Pte Ltd on behalf of Chinese Speaking Orthopaedic Society.
KeywordAntiinfection Bone cement Kyphoplasty Magnesium Osseointegration
Indexed BySCI
Language英语
WOS IDWOS:000470125300013
PublisherELSEVIER SCIENCE BV
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/81206
Collection中国科学院金属研究所
Recommended Citation
GB/T 7714
Lin, Xiao,Ge, Jun,Wei, Donglei,et al. Surface degradation-enabled osseointegrative, angiogenic and antiinfective properties of magnesium-modified acrylic bone cement[J]. JOURNAL OF ORTHOPAEDIC TRANSLATION,2019,17:121-132.
APA Lin, Xiao.,Ge, Jun.,Wei, Donglei.,Liu, Chun.,Tan, Lili.,...&Yang, Lei.(2019).Surface degradation-enabled osseointegrative, angiogenic and antiinfective properties of magnesium-modified acrylic bone cement.JOURNAL OF ORTHOPAEDIC TRANSLATION,17,121-132.
MLA Lin, Xiao,et al."Surface degradation-enabled osseointegrative, angiogenic and antiinfective properties of magnesium-modified acrylic bone cement".JOURNAL OF ORTHOPAEDIC TRANSLATION 17(2019):121-132.
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