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Study of engineered low-modulus Mg/PLLA composites as potential orthopaedic implants: An in vitro and in vivo study
Yu, Xiaobing; Huang, Wei; Zhao, Dewei; Yang, Ke; Tan, Lili; Zhang, Xiuzhi; Li, Junlei; Zhang, Meng; Zhang, Shuo; Liu, Tao; Wu, Baolin; Qu, Mingjia; Duan, Ruimeng; Yuan, Yashuai
2019-02-01
Source PublicationCOLLOIDS AND SURFACES B-BIOINTERFACES
ISSN0927-7765
Volume174Pages:280-290
AbstractLow molecular weight poly-lactic acid (PLLA) is a polymer matrix of orthopaedic implants. The PLLA matrix incorporating bioactive magnesium ion (Mg2+) enhances bone regeneration. But the optimal ratio of Mg2+ to PLLA matrix has not been well reported and is worthy of study. We synthesized silane-coated Mg/PLLA composites containing 1%, 2%, 3%, 4% and 5% Mg micro-particles. The mechanical properties, in vitro cytocompatibility, cell viability and osteogenesis differentiation and in vivo performance of silane-coated Mg/PLLA composites were evaluated. These results showed that the bending and tensile strength of PLLA matrix was reduced by incorporation of Mg micro-particles. Mg/PLLA composites with higher Mg micro-particles ratio showed higher Mg2+ leaching rate and pH value in immersion solutions. MC3T3-E1 pre-osteoblasts incubated with Mg/PLLA composites containing higher ratio of Mg micro-particles showed higher cytocompatibility, cell viability, osteogenesis differentiation and migration. In vitro cellular responses showed that MC3T3-E1 preosteoblasts had the highest cell viability at 50 ppm Mg2+. In vivo animal studies showed there was no change in serum Mg 2+ concentration after implanting Mg/PLLA composites comparing with control and the implants of silane-coated Mg/PLLA composites accelerated bone formation. In summary, our study revealed the feasibility of silane-coated Mg/PLLA composites as orthopaedic implants. Silane-coated Mg/PLLA composites with Mg micro-particles ratio of 3% similar to 5% were optimal substitutes for bone regeneration.
KeywordPoly-lactic acid Magnesium Mg/PLLA composite Bone formation Osteogenesis differentiation
Indexed BySCI
Language英语
WOS IDWOS:000459840800033
PublisherELSEVIER SCIENCE BV
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/81393
Collection中国科学院金属研究所
Recommended Citation
GB/T 7714
Yu, Xiaobing,Huang, Wei,Zhao, Dewei,et al. Study of engineered low-modulus Mg/PLLA composites as potential orthopaedic implants: An in vitro and in vivo study[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2019,174:280-290.
APA Yu, Xiaobing.,Huang, Wei.,Zhao, Dewei.,Yang, Ke.,Tan, Lili.,...&Yuan, Yashuai.(2019).Study of engineered low-modulus Mg/PLLA composites as potential orthopaedic implants: An in vitro and in vivo study.COLLOIDS AND SURFACES B-BIOINTERFACES,174,280-290.
MLA Yu, Xiaobing,et al."Study of engineered low-modulus Mg/PLLA composites as potential orthopaedic implants: An in vitro and in vivo study".COLLOIDS AND SURFACES B-BIOINTERFACES 174(2019):280-290.
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