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An Antibacterial Strategy of Mg-Cu Bone Grafting in Infection-Mediated Periodontics
Zhao, Xue; Wan, Peng; Wang, Hongyan; Zhang, Shuwei; Liu, Jingbo; Chang, Chunrong; Yang, Ke; Pan, Yaping
2020-08-28
Source PublicationBIOMED RESEARCH INTERNATIONAL
Volume2020
AbstractPeriodontal diseases are mainly the results of infections and inflammation of the gum and bone that surround and support the teeth. In this study, the alveolar bone destruction in periodontitis is hypothesized to be treated with novel Mg-Cu alloy grafts due to their antimicrobial and osteopromotive properties. In order to study this new strategy using Mg-Cu alloy grafts as a periodontal bone substitute, thein vitrodegradation and antibacterial performance were examined. The pH variation and Mg2+ and Cu2+ release of Mg-Cu alloy extracts were measured.Porphyromonas gingivalis(P. gingivalis) andAggregatibacter actinomycetemcomitans(A. actinomycetemcomitans), two common bacteria associated with periodontal disease, were cultured in Mg-Cu alloy extracts, and bacterial survival rate was evaluated. The changes of bacterial biofilm and its structure were revealed by scanning electron microscopy (SEM) and transmission electronic microscopy (TEM), respectively. The results showed that the Mg-Cu alloy could significantly decrease the survival rates of bothP. gingivalisandA. actinomycetemcomitans. Furthermore, the bacterial biofilms were completely destroyed in Mg-Cu alloy extracts, and the bacterial cell membranes were damaged, finally leading to bacterial apoptosis. These results indicate that the Mg-Cu alloy can effectively eliminate periodontal pathogens, and the use of Mg-Cu in periodontal bone grafts has a great potential to prevent infections after periodontal surgery.
DOI10.1155/2020/7289208
WOS IDWOS:000570898700002
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Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/82598
Collection中国科学院金属研究所
Recommended Citation
GB/T 7714
Zhao, Xue,Wan, Peng,Wang, Hongyan,et al. An Antibacterial Strategy of Mg-Cu Bone Grafting in Infection-Mediated Periodontics[J]. BIOMED RESEARCH INTERNATIONAL,2020,2020.
APA Zhao, Xue.,Wan, Peng.,Wang, Hongyan.,Zhang, Shuwei.,Liu, Jingbo.,...&Pan, Yaping.(2020).An Antibacterial Strategy of Mg-Cu Bone Grafting in Infection-Mediated Periodontics.BIOMED RESEARCH INTERNATIONAL,2020.
MLA Zhao, Xue,et al."An Antibacterial Strategy of Mg-Cu Bone Grafting in Infection-Mediated Periodontics".BIOMED RESEARCH INTERNATIONAL 2020(2020).
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