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Bioinspired Fabrication of Calcium-Doped TiP Coating with Nanofibrous Microstructure to Accelerate Osseointegration
Cai, Bianyun; Tan, Peijie; Jiang, Nan; Guo, Zhijun; Ay, Birol; Li, Shujun; Hou, Yi; Li, Yubao; You, Yanjun; Zhang, Li; Zhu, Songsong
2020-06-01
Source PublicationBIOCONJUGATE CHEMISTRY
Volume31Issue:6Pages:1641-1650
AbstractBioinspired by the morphology of osteoclast-resorbed bone surfaces, we prepared a calcium-doped titanium phosphate (Ca-TiP) coating, which consists of a nanofibrous network, on titanium (Ti) substrate via a simple two-step hydrothermal method, trying to mimic natural bone compositionally and microstructurally. The in vitro studies show that the Ca-TiP coating with synergistic features of nanofibrous biomimetic topography and surface chemistry could elicit intensively osteogenic behavior and responses including enhanced cell adhesion, spreading, and proliferation as well as alkaline phosphatase (ALP) activity and up-regulated expression of bone-related genes, which inevitably benefit the formation of new bone and the quality of osseointegration. When the two control groups are compared in vivo, the significantly improved new bone formation in the early stage and the much stronger interfacial bonding with the surrounding bone for Ca-TiP coating suggest that Ca-TiP coating modified Ti implants hold great potential for orthopedic and dental applications.
DOI10.1021/acs.bioconjchem.0c00201
WOS IDWOS:000542926300008
Citation statistics
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/82804
Collection中国科学院金属研究所
Recommended Citation
GB/T 7714
Cai, Bianyun,Tan, Peijie,Jiang, Nan,et al. Bioinspired Fabrication of Calcium-Doped TiP Coating with Nanofibrous Microstructure to Accelerate Osseointegration[J]. BIOCONJUGATE CHEMISTRY,2020,31(6):1641-1650.
APA Cai, Bianyun.,Tan, Peijie.,Jiang, Nan.,Guo, Zhijun.,Ay, Birol.,...&Zhu, Songsong.(2020).Bioinspired Fabrication of Calcium-Doped TiP Coating with Nanofibrous Microstructure to Accelerate Osseointegration.BIOCONJUGATE CHEMISTRY,31(6),1641-1650.
MLA Cai, Bianyun,et al."Bioinspired Fabrication of Calcium-Doped TiP Coating with Nanofibrous Microstructure to Accelerate Osseointegration".BIOCONJUGATE CHEMISTRY 31.6(2020):1641-1650.
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