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Bio-inspired anisotropic polymeric heart valves exhibiting valve-like mechanical and hemodynamic behavior
Guo, Feng; Liu, Chang; Han, Rizheng; Lu, Qiang; Bai, Yun; Yang, Rui; Niu, Dun; Zhang, Xing
2020-04-01
Source PublicationSCIENCE CHINA-MATERIALS
Volume63Issue:4Pages:629-643
AbstractNative heart valve leaflets with layered fibrous structures show anisotropic characteristics, allowing them to withstand complex mechanical loading for long-term cardiac cycles. Herein, two types of silk fibroin (SF) fiber membranes with anisotropic (ASF) and isotropic (ISF) properties were prepared by electrospinning, and were further combined with poly(ethylene glycol) diacrylate (PEGDA) hydrogels to serve as polymeric heart valve (PHV) substitutes (PEGDA-ASF and PEGDA-ISF). The uniaxial tensile tests showed obvious ani-sotropy of PEGDA-ASF with elastic moduli of 10.95 +/- 1.09 and 3.55 +/- 0.32 MPa, respectively, along the directions parallel and perpendicular to the fiber alignment, while PEGDA-ISF possessed isotropic property with elastic moduli of 4.54 +/- 0.43 MPa. The PHVs from both PEGDA-ASF and PEGDA-ISF presented appropriate hydrodynamic properties from pulse duplicator tests according to the ISO 5840-3 standard. However, finite element analysis (FEA) revealed the anisotropic PEGDA-ASF valve showed a lower maximum principle stress value (2.20 MPa) in commissures during diastole compared with that from the isotropic PEGDA-ISF valve (2.37 MPa). In the fully open state, the bending area of the PEGDA-ASF valve appeared in the belly portion and near the attachment line like native valves, however, which was close to free edges for the PEGDA-ISF valve. The Gauss curvature analysis also indicated that the anisotropic PEGDA-ASF valve can produce appropriate surface morphology by dynamically adjusting the movement of bending area during the opening process. Hence, anisotropy of PHVs with bio-inspired layered fibrous structures played important roles in mechanical and hydrodynamic behavior mimicking native heart valves.
DOI10.1007/s40843-019-1217-4
WOS IDWOS:000519466600016
Citation statistics
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/82988
Collection中国科学院金属研究所
Recommended Citation
GB/T 7714
Guo, Feng,Liu, Chang,Han, Rizheng,et al. Bio-inspired anisotropic polymeric heart valves exhibiting valve-like mechanical and hemodynamic behavior[J]. SCIENCE CHINA-MATERIALS,2020,63(4):629-643.
APA Guo, Feng.,Liu, Chang.,Han, Rizheng.,Lu, Qiang.,Bai, Yun.,...&Zhang, Xing.(2020).Bio-inspired anisotropic polymeric heart valves exhibiting valve-like mechanical and hemodynamic behavior.SCIENCE CHINA-MATERIALS,63(4),629-643.
MLA Guo, Feng,et al."Bio-inspired anisotropic polymeric heart valves exhibiting valve-like mechanical and hemodynamic behavior".SCIENCE CHINA-MATERIALS 63.4(2020):629-643.
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