IMR OpenIR
Regulatory T Cells in Cancer Immunotherapy: Basic Research Outcomes and Clinical Directions
Zeng, Guoming; Jin, Libo; Ying, Qinsi; Chen, Haojie; Thembinkosi, Murinda Charmaine; Yang, Chunguang; Zhao, Jinlong; Ji, Hao; Lin, Sue; Peng, Renyi; Zhang, Maolan; Sun, Da
2020-07-12
Source PublicationCANCER MANAGEMENT AND RESEARCH
Volume12Pages:10411-10421
AbstractCancer immunotherapy is a promising approach that has recently gained its importance in treating cancer. Despite various approaches of immunotherapies being used to target cancer cells, they are either not effective against all types of cancer or for all patients. Although efforts are being made to improve the cancer immunotherapy in all possible ways, one important hindrance that lowers the immune response to kill cancer cells is the infiltration of Regulatory T (Treg) cells into the tumor cells, favoring tumor progression, on one hand, and inhibiting the activation of T cells to respond to cancer cells, on the other hand. Therefore, new anti-cancer drugs and vaccines fail to show promising results against cancer. This is due to the infiltration of Treg cells into the tumor region and suppression of anti-cancer activity. Thus, regardless of various types of immunotherapies being practiced, understanding the mechanisms of how Treg cells favor tumor progression and inhibition of anti-cancer activity is worthwhile. Therefore, the review highlights the importance of Tregs cells and how depletion of Treg cells can pave the way to an effective immunotherapy by activating the immune responses against cancer.
DOI10.2147/CMAR.S265828
WOS IDWOS:000579720000004
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Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/83253
Collection中国科学院金属研究所
Recommended Citation
GB/T 7714
Zeng, Guoming,Jin, Libo,Ying, Qinsi,et al. Regulatory T Cells in Cancer Immunotherapy: Basic Research Outcomes and Clinical Directions[J]. CANCER MANAGEMENT AND RESEARCH,2020,12:10411-10421.
APA Zeng, Guoming.,Jin, Libo.,Ying, Qinsi.,Chen, Haojie.,Thembinkosi, Murinda Charmaine.,...&Sun, Da.(2020).Regulatory T Cells in Cancer Immunotherapy: Basic Research Outcomes and Clinical Directions.CANCER MANAGEMENT AND RESEARCH,12,10411-10421.
MLA Zeng, Guoming,et al."Regulatory T Cells in Cancer Immunotherapy: Basic Research Outcomes and Clinical Directions".CANCER MANAGEMENT AND RESEARCH 12(2020):10411-10421.
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