Synthesis and cytotoxicity studies of quinoline-3-carbonitrile derivatives

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	Synthesis and cytotoxicity studies of quinoline-3-carbonitrile derivatives
其他题名	Synthesis and cytotoxicity studies of quinoline-3-carbonitrile derivatives
	Zhang Shu Lan; Zhai Xin; Zhang Shi Jiao; Yu Hong Hao; Gong Ping
	2010
发表期刊	CHINESE CHEMICAL LETTERS
ISSN	1001-8417
卷号	21 期号:8 页码:939-942
摘要	A series of quinoline-3-carbonitrile derivatives were designed and synthesized. Their cytotoxicity in vitro against four cancer cell lines (A549, HT-29, MDA-MB-231 and SMMC-7721) were evaluated by standard MTT assay. The pharmacological results showed that most of the prepared compounds displayed excellent selective cytotoxicity toward SMMC-7721 cell line. Among them, compounds 7c, 7e, 11b, 11f and 11g were more active than Gefitinb against SMMC-7721 cell line. (C) 2010 Ping Gong. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
其他摘要	A series of quinoline-3-carbonitrile derivatives were designed and synthesized. Their cytotoxicity in vitro against four cancer cell lines (A549, HT-29, MDA-MB-231 and SMMC-7721) were evaluated by standard MTT assay. The pharmacological results showed that most of the prepared compounds displayed excellent selective cytotoxicity toward SMMC-7721 cell line. Among them, compounds 7c, 7e, l1b, 11f and 11g were more active than Gefitinb against SMMC-7721 cell line
关键词	KINASE THERAPY Quinoline-3-carbonitrile Synthesis Cytotoxicity
收录类别	CSCD
语种	英语
CSCD记录号	CSCD:3968944
引用统计	被引频次：1[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/87000
专题	中国科学院金属研究所
作者单位	中国科学院金属研究所
推荐引用方式 GB/T 7714	Zhang Shu Lan,Zhai Xin,Zhang Shi Jiao,et al. Synthesis and cytotoxicity studies of quinoline-3-carbonitrile derivatives[J]. CHINESE CHEMICAL LETTERS,2010,21(8):939-942.
APA	Zhang Shu Lan,Zhai Xin,Zhang Shi Jiao,Yu Hong Hao,&Gong Ping.(2010).Synthesis and cytotoxicity studies of quinoline-3-carbonitrile derivatives.CHINESE CHEMICAL LETTERS,21(8),939-942.
MLA	Zhang Shu Lan,et al."Synthesis and cytotoxicity studies of quinoline-3-carbonitrile derivatives".CHINESE CHEMICAL LETTERS 21.8(2010):939-942.