Growth inhibition of breast cancer in rat by AAV mediated angiostatin gene

IMR OpenIR

	Growth inhibition of breast cancer in rat by AAV mediated angiostatin gene
其他题名	Growth Inhibition of Breast Cancer in Rat by AAV Mediated Angiostatin Gene
	Li Ran; Chen Hong; Ren Changshan
	2007
发表期刊	CHINESE JOURNAL OF CANCER RESEARCH
ISSN	1000-9604
卷号	19 期号:2 页码:108-112
摘要	Objective: To observe growth inhibition effect of adeno-associated viral vectors (AAV) mediated angiostatin (ANG) gene on implanted breast cancer in rat and its mechanism. Methods: Gene transfer technique was used to transfer AAV-ANG to the tumor. Growth curves were drawn to observe the growth of breast cancer implanted in rat, and immunohistochemical method was used to detect the effects of angiostatin on microvesel density (MVD) of breast cancer implanted in rat. Results: Angiostatin inhibited the growth of breast cancer implanted in rat and decreased the microvessel density of tumor. Conclusion: Expression of an angiostatin transgene can suppress the growth of breast cancer implanted in rat through the inhibition of the growth of microvessels, surggesting that angiostatin gene transfer technique may be effective against breast cancer.
其他摘要	Objective: To observe growth inhibition effect of adeno-associated viral vectors (AAV) mediated angiostatin (ANG) gene on implanted breast cancer in rat and its mechanism. Methods: Gene transfer technique was used to transfer AAV-ANG to the tumor. Growth curves were drawn to observe the growth of breast cancer implanted in rat, and immunohistochemical method was used to detect the effects of angiostatin on microvesel density (MVD) of breast cancer implanted in rat. Results: Angiostatin inhibited the growth of breast cancer implanted in rat and decreased the microvessel density of tumor. Conclusion: Expression of an angiostatin transgene can suppress the growth of breast cancer implanted in rat through the inhibition of the growth of microvessels, surggesting that angiostatin gene transfer technique may be effective against breast cancer.
关键词	ANGIOGENESIS MECHANISMS AAV-ANG breast cancer growth inhibition microvessel density
收录类别	CSCD
语种	英语
CSCD记录号	CSCD:2911737
引用统计	被引频次：1[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/87687
专题	中国科学院金属研究所
作者单位	中国科学院金属研究所
推荐引用方式 GB/T 7714	Li Ran,Chen Hong,Ren Changshan. Growth inhibition of breast cancer in rat by AAV mediated angiostatin gene[J]. CHINESE JOURNAL OF CANCER RESEARCH,2007,19(2):108-112.
APA	Li Ran,Chen Hong,&Ren Changshan.(2007).Growth inhibition of breast cancer in rat by AAV mediated angiostatin gene.CHINESE JOURNAL OF CANCER RESEARCH,19(2),108-112.
MLA	Li Ran,et al."Growth inhibition of breast cancer in rat by AAV mediated angiostatin gene".CHINESE JOURNAL OF CANCER RESEARCH 19.2(2007):108-112.