Allergen micro-array detection of specific IgE-reactivity in Chinese allergy patients

IMR OpenIR

	Allergen micro-array detection of specific IgE-reactivity in Chinese allergy patients
其他题名	Allergen micro-array detection of specific IgE-reactivity in Chinese allergy patients
	Zheng Yiwu 1; Li Jing 1; Lai Xuxin 1; Zhao Deyu 2; Liu Xiaofan 3; Lin Xiaoping 4; Gjesing Birgitte 1; Palazzo Paola 5; Mari Adriano 5; Zhong Nanshan 1; Spangfort Michael D 1
	2011
发表期刊	CHINESE MEDICAL JOURNAL
ISSN	0366-6999
卷号	124 期号:24 页码:4350-4354
摘要	Background Allergen micro-arrays are powerful tools for screening of serum IgE-reactivity. In this study allergen micro-arrays were used to identify dominating IgE-binding allergens and cross-reactivity patterns among selected Chinese allergy patients.
其他摘要	Background Allergen micro-arrays are powerful tools for screening of serum IgE-reactivity. In this study allergen micro-arrays were used to identify dominating IgE-binding allergens and cross-reactivity patterns among selected Chinese allergy patients. Methods The study was conducted using patient sera from the cities of Guangzhou, Nanjing, Chengdu and Shenyang. In total 100 sera with Dermatophagoides pteronyssinus (Der p) specific IgE-levels higher than 50 kU/L were selected for testing against 103 individual allergens. Results Among 100 selected patients, 95% showed IgE-reactivity towards house-dust mite allergens Dermatophagoides farinae (Der f) 1, Der f 2 and Der p 2 and 94% were IgE positive against Der p 1, and 60% of sera contained IgE reacting against allergen Euroglyphus maynei (Eur m) 2. IgE against cat allergen, Felisdomesticus (Fel d) 1, was seen in 20%. Only 2% showed specific IgE-reactivity to Der p 10, a panallergen belonging to the tropomyosin family. Serum IgE-reactivity towards other allergens was in general low. IgE-reactivity against pollen allergens showed geographic differences. Conclusions This study clearly confirms that group 1 and group 2 are major allergens of house dust mites. These selected house-dust mite allergy patients are close to being mono-sensitized. Der p 10 is not an important allergen for cross-reactivity. Specific IgE-sensitization towards pollen allergens is low in southern China compared to other regions. The prevalence of food and stinging insect allergens known to give rise to IgE-mediated cross-reactivity is 2% or less.
关键词	specific immuno globulin E micro-array Dermatophagoides pteronyssinus Dermatophagoides farinae cross-reactivity
收录类别	CSCD
语种	英语
CSCD记录号	CSCD:4401040
引用统计	被引频次：13[CSCD] [CSCD记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/89886
专题	中国科学院金属研究所
作者单位	1.中国科学院广州地球化学研究所 2.中国科学院南京地理与湖泊研究所 3.成都学院 4.中国科学院金属研究所 5.IDI IRCCS, Ctr Clin & Expt Allergol, Rome, Italy
推荐引用方式 GB/T 7714	Zheng Yiwu,Li Jing,Lai Xuxin,et al. Allergen micro-array detection of specific IgE-reactivity in Chinese allergy patients[J]. CHINESE MEDICAL JOURNAL,2011,124(24):4350-4354.
APA	Zheng Yiwu.,Li Jing.,Lai Xuxin.,Zhao Deyu.,Liu Xiaofan.,...&Spangfort Michael D.(2011).Allergen micro-array detection of specific IgE-reactivity in Chinese allergy patients.CHINESE MEDICAL JOURNAL,124(24),4350-4354.
MLA	Zheng Yiwu,et al."Allergen micro-array detection of specific IgE-reactivity in Chinese allergy patients".CHINESE MEDICAL JOURNAL 124.24(2011):4350-4354.