| Effect of ionic liquids as additives on the separation of bases and amino acids in HPLC | |
| Jiang, Qiong1; Qiu, Hongdeng2,3; Wang, Xusheng2; Liu, Xia2; Zhang, Shusheng1 | |
| Corresponding Author | Zhang, Shusheng(menghuanrou@163.com) |
| 2008 | |
| Source Publication | JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES
 |
| ISSN | 1082-6076 |
| Volume | 31Issue:10Pages:1448-1457 |
| Abstract | In this paper, four bases, including cytosine, thymine, adenine, 6-chlorouracil and four amino acids, including L-histidine, L-tyrosine, L-phenylalanine, and DL-tryptophane, were separated with different types of ionic liquids as additives for the mobile phase in high-performance liquid chromatography. Four different ILs, including 1-ethyl-3-methylimidazolium tetrafluoroborate, 1-butyl-3-methylimidazolium tetrafluoroborate, 1-hexyl-3-methylimidazolium tetrafluoroborate, and 1-butyl-3-methylimidazolium chloride were used. The effects of the length of the alkyl group on the imidazolium ring and its counterion, the concentrations of the ionic liquids on the retention factor of the bases and amino acids are investigated. The results showed that the retention and resolution of the bases and amino acids were improved when ionic liquids were used as additives. The mechanism at the separation with ionic liquids as additive to mobile phase is discussed. |
| Keyword | ionic liquid additive base amino acid high-performance liquid chromatography |
| DOI | 10.1080/10826070802039424 |
| Indexed By | SCI |
| Language | 英语 |
| WOS Research Area | Biochemistry & Molecular Biology ; Chemistry |
| WOS Subject | Biochemical Research Methods ; Chemistry, Analytical |
| WOS ID | WOS:000255272900005 |
| Publisher | TAYLOR & FRANCIS INC |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/93259 |
| Collection | 中国科学院金属研究所 |
| Corresponding Author | Zhang, Shusheng |
| Affiliation | 1.Zhengzhou Univ, Dept Chem, Key Lab Chem Biol & Organ Chem Henan, Zhengzhou 450052, Peoples R China 2.Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Nat Med Gansu Prov, Lanzhou 730000, Peoples R China 3.Chinese Acad Sci, Grad Sch Chinese Acad Sci, Beijing, Peoples R China |
| Recommended Citation GB/T 7714 | Jiang, Qiong,Qiu, Hongdeng,Wang, Xusheng,et al. Effect of ionic liquids as additives on the separation of bases and amino acids in HPLC[J]. JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES,2008,31(10):1448-1457. |
| APA | Jiang, Qiong,Qiu, Hongdeng,Wang, Xusheng,Liu, Xia,&Zhang, Shusheng.(2008).Effect of ionic liquids as additives on the separation of bases and amino acids in HPLC.JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES,31(10),1448-1457. |
| MLA | Jiang, Qiong,et al."Effect of ionic liquids as additives on the separation of bases and amino acids in HPLC".JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES 31.10(2008):1448-1457. |
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