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Design, Synthesis and Biological Activities of N-(Furan-2-ylmethyl)-1H-indole-3-carboxamide Derivatives as Epidemal Growth Factor Receptor Inhibitors and Anticancer Agents 期刊论文
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES, 2017, 卷号: 33, 期号: 3, 页码: 365-372
作者:  Zhang Lan;  Deng Xinshan;  Wu Jiaofeng;  Meng Guangpeng;  Liu Congchong;  Chen Guzhou;  Zhao Qingchun;  Hu Chun
收藏  |  浏览/下载：147/0  |  提交时间：2021/02/02
MOLECULAR TARGETED DRUGS  TYROSINE KINASE  CANCER-CELLS  EGFR  RESISTANCE  POTENT  DISCOVERY  NSCLC  Anticancer activity  Epidemal growth factor receptor(EGFR) inhibitor  N-( Furan-2-ylmethyl)-1H-indole3-carboxamide derivative  
Design, Synthesis and Biological Activities of N-(Furan-2-ylmethyl)-1H-indole-3-carboxamide Derivatives as Epidemal Growth Factor Receptor Inhibitors and Anticancer Agents 期刊论文
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES, 2017, 卷号: 33, 期号: 3, 页码: 365-372
作者:  Zhang Lan;  Deng Xinshan;  Wu Jiaofeng;  Meng Guangpeng;  Liu Congchong;  Chen Guzhou;  Zhao Qingchun;  Hu Chun
收藏  |  浏览/下载：141/0  |  提交时间：2021/02/02
MOLECULAR TARGETED DRUGS  TYROSINE KINASE  CANCER-CELLS  EGFR  RESISTANCE  POTENT  DISCOVERY  NSCLC  Anticancer activity  Epidemal growth factor receptor(EGFR) inhibitor  N-( Furan-2-ylmethyl)-1H-indole3-carboxamide derivative  
Identification of hydrazone moiety-bearing aminopyrimidines as potent antitumor agents with selective inhibition of gefitinib-resistant H1975 cancer cells 期刊论文
CHINESE CHEMICAL LETTERS, 2017, 卷号: 28, 期号: 5, 页码: 991-994
作者:  Qin MingZe;  Wang Lei;  Yan Shuang;  Ma JunJie;  Tian Ye;  Zhao YanFang;  Gong Ping
收藏  |  浏览/下载：153/0  |  提交时间：2021/02/02
TYROSINE KINASE INHIBITOR  LUNG-CANCER  RECEPTOR  T790M  MUTANT  MUTATION  Aminopyrimidines  EGFR T790M/L858R  Selectivity  Anti-resistance  Antiproliferative activity  
Identification of hydrazone moiety-bearing aminopyrimidines as potent antitumor agents with selective inhibition of gefitinib-resistant H1975 cancer cells 期刊论文
CHINESE CHEMICAL LETTERS, 2017, 卷号: 28, 期号: 5, 页码: 991-994
作者:  Qin MingZe;  Wang Lei;  Yan Shuang;  Ma JunJie;  Tian Ye;  Zhao YanFang;  Gong Ping
收藏  |  浏览/下载：135/0  |  提交时间：2021/02/02
TYROSINE KINASE INHIBITOR  LUNG-CANCER  RECEPTOR  T790M  MUTANT  MUTATION  Aminopyrimidines  EGFR T790M/L858R  Selectivity  Anti-resistance  Antiproliferative activity  
Biodegradable magnesium wire promotes regeneration of compressed sciatic nerves 期刊论文
NEURAL REGENERATION RESEARCH, 2016, 卷号: 11, 期号: 12, 页码: 2012-2017
作者:  Li, Bo-han;  Yang, Ke;  Wang, Xiao
收藏  |  浏览/下载：128/0  |  提交时间：2021/02/02
nerve regeneration  peripheral nerve regeneration  biodegradable  magnesium wire  sciatic nerve  rats  nerve growth factor  P75 neurotrophin receptor  tyrosine receptor kinase A  neural regeneration  
Discovery of a new series of imidazo1,2-apyridine compounds as selective c-Met inhibitors 期刊论文
ACTA PHARMACOLOGICA SINICA, 2016, 卷号: 37, 期号: 5, 页码: 698-707
作者:  Liu Tongchao;  Peng Xia;  Ma Yuchi;  Ji Yinchun;  Chen Danqi;  Zheng Mingyue;  Zhao Dongmei;  Cheng Maosheng;  Geng Meiyu;  Shen Jingkang;  Ai Jing;  Xiong Bing
收藏  |  浏览/下载：153/0  |  提交时间：2021/02/02
RECEPTOR TYROSINE KINASE  INVASIVE GROWTH  SCATTER FACTOR  CANCER  DOCKING  c-Met inhibitors  hepatocyte growth factor receptor  imidazo1,2-apyridine  anticancer agents  drug discovery  
Discovery of a new series of imidazo1,2-apyridine compounds as selective c-Met inhibitors 期刊论文
ACTA PHARMACOLOGICA SINICA, 2016, 卷号: 37, 期号: 5, 页码: 698-707
作者:  Liu Tongchao;  Peng Xia;  Ma Yuchi;  Ji Yinchun;  Chen Danqi;  Zheng Mingyue;  Zhao Dongmei;  Cheng Maosheng;  Geng Meiyu;  Shen Jingkang;  Ai Jing;  Xiong Bing
收藏  |  浏览/下载：129/0  |  提交时间：2021/02/02
RECEPTOR TYROSINE KINASE  INVASIVE GROWTH  SCATTER FACTOR  CANCER  DOCKING  c-Met inhibitors  hepatocyte growth factor receptor  imidazo1,2-apyridine  anticancer agents  drug discovery  
Discovery of Novel Tricyclic 5H-Pyridazino4,5-bindoles as Potent Antitumor Agents: Design, Synthesis and Biological Evaluation 期刊论文
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES, 2015, 卷号: 31, 期号: 3, 页码: 372-380
作者:  Zhai Xin;  Wang Limei;  Shi Jiyue;  Gong Ping
收藏  |  浏览/下载：123/0  |  提交时间：2021/02/02
TYROSINE KINASE INHIBITORS  GROWTH-FACTOR RECEPTOR  ANALOGS  DERIVATIVES  BINDING  HARMINE  1-Anilino-5H-pyridazino4,5-bindole  EGFR inhibitor  Cytotoxicity  
Energetic factors determining the binding of type I inhibitors to c-Met kinase: experimental studies and quantum mechanical calculations 期刊论文
ACTA PHARMACOLOGICA SINICA, 2013, 卷号: 34, 期号: 11, 页码: 1475-1483
作者:  Yu Zhe;  Ma Yuchi;  Ai Jing;  Chen Danqi;  Zhao Dongmei;  Wang Xin;  Chen Yuelei;  Geng Meiyu;  Xiong Bing;  Cheng Maosheng;  Shen Jingkang
收藏  |  浏览/下载：145/0  |  提交时间：2021/02/02
SULFUR-PI INTERACTIONS  PERTURBATION-THEORY  SUBSTITUENTS  SANDWICH  BENZENE  PATHWAY  receptor tyrosine kinase  type I c-Met inhibitor  cancer  quantum chemistry  protein-ligand interaction  symmetry-adapted perturbation theory (SAPT)  
Energetic factors determining the binding of type I inhibitors to c-Met kinase: experimental studies and quantum mechanical calculations 期刊论文
ACTA PHARMACOLOGICA SINICA, 2013, 卷号: 34, 期号: 11, 页码: 1475-1483
作者:  Yu Zhe;  Ma Yuchi;  Ai Jing;  Chen Danqi;  Zhao Dongmei;  Wang Xin;  Chen Yuelei;  Geng Meiyu;  Xiong Bing;  Cheng Maosheng;  Shen Jingkang
收藏  |  浏览/下载：107/0  |  提交时间：2021/02/02
SULFUR-PI INTERACTIONS  PERTURBATION-THEORY  SUBSTITUENTS  SANDWICH  BENZENE  PATHWAY  receptor tyrosine kinase  type I c-Met inhibitor  cancer  quantum chemistry  protein-ligand interaction  symmetry-adapted perturbation theory (SAPT)