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Discovery of a novel small inhibitor RJ19 targeting to human Hsp90 期刊论文
NUCLEAR SCIENCE AND TECHNIQUES, 2017, 卷号: 28, 期号: 10
作者:  Cao HuiLing;  Lyu KaiKai;  Liu Bin;  Li Jian;  He JianHua
收藏  |  浏览/下载：145/0  |  提交时间：2021/02/26
ATP HYDROLYSIS  PROTEIN  CHAPERONE  IDENTIFICATION  BINDING  DESIGN  Heat shock protein 90  Drug target  Inhibitor  X-ray diffraction  Complex crystal structure  
Ligand-Based Structural Optimization of Grb2-SH2 Inhibitors: High Affinity, Low Charge and Reduced Peptidic Nature 期刊论文
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2011, 卷号: 31, 期号: 12, 页码: 2019-2033
作者:  Peng Dian;  Zhi Ying;  Xue Ting;  Gao Huiyuan;  Long Yaqiu
收藏  |  浏览/下载：97/0  |  提交时间：2021/02/02
STRUCTURE-BASED DESIGN  RING-CLOSING METATHESIS  SH2 DOMAIN  NONPHOSPHORYLATED INHIBITOR  PHOSPHOTYROSYL MIMETICS  ACID-RESIDUES  BINDING  ANTAGONISTS  POSITION  REQUIREMENTS  phosphotyrosine  Grb2-SH2 inhibitor  structure-activity relationship  mitogenic ras pathway  anti-tumor drug  
A model of 3D-structure of H+, K+-ATPase catalytic subunit derived by homology modeling 期刊论文
ACTA PHARMACOLOGICA SINICA, 2004, 卷号: 25, 期号: 4, 页码: 474-479
作者:  Yan D;  Hu YD;  Li S;  Cheng MS
收藏  |  浏览/下载：67/0  |  提交时间：2021/02/02
GASTRIC H+/K+-ATPASE  OMEPRAZOLE  MEMBRANE  TRANSPORT  PUMP  peptic ulcer  H(+)-K(+)-exchanging ATPase  protein structural homology  drug design