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Design, synthesis and antitumor activity evaluation of novel 2,6-dichloro- 3,5-dinitrotoluene derivatives 期刊论文
Journal of Chinese Pharmaceutical Sciences, 2018, 卷号: 27, 期号: 3, 页码: 159-169
Authors:  Jiao Jiayuan;  Hu Hao;  Wei Siyuan;  Wang Wanqiu;  Lin He;  Chai Baoshan
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6-二氯3  5-二硝基甲苯  细胞毒活性  构效关系  
Synthesis, Anticancer and Antibacterial Activities of Novel 2-Amino-4-phenylthiazole Derivatives Containing Amide Moiety 期刊论文
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2017, 卷号: 37, 期号: 9, 页码: 2377-2384
Authors:  Zhang Zhihua;  Chen Yu;  Chai Baoshan;  Yang Xiaoman;  Cai Xiaoyu;  Cui Bo;  You Song
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BIOLOGICAL EVALUATION  KINASE INHIBITORS  SORAFENIB ANALOGS  ANTITUMOR AGENTS  RATIONAL DESIGN  2-AMINOTHIAZOLES  BRAF  MELANOMA  THIOUREA  GROWTH  thiazole derivative  amide  synthesis  anticancer  antibacterial  
Identification of hydrazone moiety-bearing aminopyrimidines as potent antitumor agents with selective inhibition of gefitinib-resistant H1975 cancer cells 期刊论文
CHINESE CHEMICAL LETTERS, 2017, 卷号: 28, 期号: 5, 页码: 991-994
Authors:  Qin MingZe;  Wang Lei;  Yan Shuang;  Ma JunJie;  Tian Ye;  Zhao YanFang;  Gong Ping
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TYROSINE KINASE INHIBITOR  LUNG-CANCER  RECEPTOR  T790M  MUTANT  MUTATION  Aminopyrimidines  EGFR T790M/L858R  Selectivity  Anti-resistance  Antiproliferative activity  
Identification of hydrazone moiety-bearing aminopyrimidines as potent antitumor agents with selective inhibition of gefitinib-resistant H1975 cancer cells 期刊论文
CHINESE CHEMICAL LETTERS, 2017, 卷号: 28, 期号: 5, 页码: 991-994
Authors:  Qin MingZe;  Wang Lei;  Yan Shuang;  Ma JunJie;  Tian Ye;  Zhao YanFang;  Gong Ping
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TYROSINE KINASE INHIBITOR  LUNG-CANCER  RECEPTOR  T790M  MUTANT  MUTATION  Aminopyrimidines  EGFR T790M/L858R  Selectivity  Anti-resistance  Antiproliferative activity  
Cooperation of Two Biosynthetic Gene Clusters in the Biosynthesis of New Anthracycline Polyketide 期刊论文
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2017, 卷号: 37, 期号: 12, 页码: 3262-3266
Authors:  Zhou Hongyang;  Luo Guangcai;  Zhang Zhuan;  Zhou Qiang;  Zhai Xin;  Tang GongLi
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ANTITUMOR-ACTIVITY  KOSINOSTATIN  anthracycline  hexose 3,4-dehydratase  biosynthesis  gene cluster cooperation  
Determination of 6258-70, a new semi-synthetic taxane, in rat plasma and tissues: Application to the pharmacokinetics and tissue distribution study 期刊论文
Journal of Pharmaceutical Analysis, 2016, 卷号: 6, 期号: 4, 页码: 219-225
Authors:  Zhao Simin;  Zhang Yuanyuan;  Ju Ping;  Gu Liqiang;  Zhuang Rui;  Zhao Longshan;  Tang Xing;  Bi Kaishun;  Chen Xiaohui
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6258-70  HPLC–MS/MS  Pharmacokinetics  Tissue distribution  Therapeutics. Pharmacology  RM1-950  
Design, Synthesis and Biological Evaluation of Novel Benzothiazole Derivatives Bearing Semicarbazone Moiety as Antitumor Agents 期刊论文
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES, 2015, 卷号: 31, 期号: 6, 页码: 958-963
Authors:  Ma Junjie;  Hu Gang;  Xie Lijun;  Chen Lei;  Xu Boxuan;  Gong Ping
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POTENT  INHIBITORS  ONCRASIN-1  DISCOVERY  Benzothiazole  Semicarbazone  Antitumor activity  
Design, Synthesis and Biological Evaluation of Novel Benzothiazole Derivatives Bearing Semicarbazone Moiety as Antitumor Agents 期刊论文
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES, 2015, 卷号: 31, 期号: 6, 页码: 958-963
Authors:  Ma Junjie;  Hu Gang;  Xie Lijun;  Chen Lei;  Xu Boxuan;  Gong Ping
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POTENT  INHIBITORS  ONCRASIN-1  DISCOVERY  Benzothiazole  Semicarbazone  Antitumor activity  
Design, Synthesis and Pharmacological Evaluation of Novel 4-Phenoxyquinoline Derivatives as Potential Antitumor Agents 期刊论文
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES, 2015, 卷号: 31, 期号: 5, 页码: 746-755
Authors:  Hu Hao;  Jiang Mingyan;  Xie Lijun;  Hu Gang;  Zhang Cuirong;  Zhang Lixia;  Zhou Shunguang;  Zhang Meihui;  Gong Ping
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MET KINASE INHIBITORS  GROWTH-FACTOR RECEPTOR  C-MET  6,7-DISUBSTITUTED-4-PHENOXYQUINOLINE DERIVATIVES  BIOLOGICAL EVALUATION  DISCOVERY  MOIETY  BEARING  IDENTIFICATION  4-Phenoxyquinoline derivative  Cytotoxic activity  3-Amino-2-cyano-acrylamide  
Design, Synthesis and Antitumor Activity of Novel 6,7-Dimethoxyquinazoline Derivatives Containing Diaryl Urea Moiety 期刊论文
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES, 2015, 卷号: 31, 期号: 5, 页码: 766-773
Authors:  Hou Yunlei;  Wu Shasha;  Ma Longsheng;  Bai Jinying;  Liu Zijian;  Zhao Yanfang
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RECEPTOR TYROSINE KINASES  BIOLOGICAL EVALUATION  HIGHLY POTENT  INHIBITOR  IDENTIFICATION  GROWTH  DISCOVERY  SORAFENIB  EGFR  6,7-Dimethoxyquinazoline derivative  Diaryl urea scaffold  Cytotoxic activity