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Design, Synthesis, Biological Activity and Molecular Docking Study of Coumarin Derivatives Bearing 2-Methylbiphenyl Moiety 期刊论文
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES, 2019, 卷号: 35, 期号: 3, 页码: 410-417
Authors:  Ma Junjie;  Huang Kun;  Ni Xin;  Chen Roufen;  Xu Boxuan;  Wang Cuifang
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GROWTH  POTENT  Coumarin  2-Methylbiphenyl  Anticancer activity  PD-1/PD-L1 inhibitory activity  Molecular docking  
Design, Synthesis and Biological Activities of N-(Furan-2-ylmethyl)-1H-indole-3-carboxamide Derivatives as Epidemal Growth Factor Receptor Inhibitors and Anticancer Agents 期刊论文
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES, 2017, 卷号: 33, 期号: 3, 页码: 365-372
Authors:  Zhang Lan;  Deng Xinshan;  Wu Jiaofeng;  Meng Guangpeng;  Liu Congchong;  Chen Guzhou;  Zhao Qingchun;  Hu Chun
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MOLECULAR TARGETED DRUGS  TYROSINE KINASE  CANCER-CELLS  EGFR  RESISTANCE  POTENT  DISCOVERY  NSCLC  Anticancer activity  Epidemal growth factor receptor(EGFR) inhibitor  N-( Furan-2-ylmethyl)-1H-indole3-carboxamide derivative  
Design, Synthesis and Biological Activities of N-(Furan-2-ylmethyl)-1H-indole-3-carboxamide Derivatives as Epidemal Growth Factor Receptor Inhibitors and Anticancer Agents 期刊论文
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES, 2017, 卷号: 33, 期号: 3, 页码: 365-372
Authors:  Zhang Lan;  Deng Xinshan;  Wu Jiaofeng;  Meng Guangpeng;  Liu Congchong;  Chen Guzhou;  Zhao Qingchun;  Hu Chun
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MOLECULAR TARGETED DRUGS  TYROSINE KINASE  CANCER-CELLS  EGFR  RESISTANCE  POTENT  DISCOVERY  NSCLC  Anticancer activity  Epidemal growth factor receptor(EGFR) inhibitor  N-( Furan-2-ylmethyl)-1H-indole3-carboxamide derivative  
Synthesis, Anticancer and Antibacterial Activities of Novel 2-Amino-4-phenylthiazole Derivatives Containing Amide Moiety 期刊论文
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2017, 卷号: 37, 期号: 9, 页码: 2377-2384
Authors:  Zhang Zhihua;  Chen Yu;  Chai Baoshan;  Yang Xiaoman;  Cai Xiaoyu;  Cui Bo;  You Song
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BIOLOGICAL EVALUATION  KINASE INHIBITORS  SORAFENIB ANALOGS  ANTITUMOR AGENTS  RATIONAL DESIGN  2-AMINOTHIAZOLES  BRAF  MELANOMA  THIOUREA  GROWTH  thiazole derivative  amide  synthesis  anticancer  antibacterial  
Discovery of a new series of imidazo1,2-apyridine compounds as selective c-Met inhibitors 期刊论文
ACTA PHARMACOLOGICA SINICA, 2016, 卷号: 37, 期号: 5, 页码: 698-707
Authors:  Liu Tongchao;  Peng Xia;  Ma Yuchi;  Ji Yinchun;  Chen Danqi;  Zheng Mingyue;  Zhao Dongmei;  Cheng Maosheng;  Geng Meiyu;  Shen Jingkang;  Ai Jing;  Xiong Bing
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RECEPTOR TYROSINE KINASE  INVASIVE GROWTH  SCATTER FACTOR  CANCER  DOCKING  c-Met inhibitors  hepatocyte growth factor receptor  imidazo1,2-apyridine  anticancer agents  drug discovery  
Discovery of a new series of imidazo1,2-apyridine compounds as selective c-Met inhibitors 期刊论文
ACTA PHARMACOLOGICA SINICA, 2016, 卷号: 37, 期号: 5, 页码: 698-707
Authors:  Liu Tongchao;  Peng Xia;  Ma Yuchi;  Ji Yinchun;  Chen Danqi;  Zheng Mingyue;  Zhao Dongmei;  Cheng Maosheng;  Geng Meiyu;  Shen Jingkang;  Ai Jing;  Xiong Bing
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RECEPTOR TYROSINE KINASE  INVASIVE GROWTH  SCATTER FACTOR  CANCER  DOCKING  c-Met inhibitors  hepatocyte growth factor receptor  imidazo1,2-apyridine  anticancer agents  drug discovery  
Isoindolone derivative QSN-10c induces leukemic cell apoptosis and suppresses angiogenesis via PI3K/AKT signaling pathway inhibition 期刊论文
ACTA PHARMACOLOGICA SINICA, 2014, 卷号: 35, 期号: 5, 页码: 625-635
Authors:  Lv Wenwen;  Qin Sining;  Chen Congqin;  Zhang Jinjie;  Ren Tianshu;  Xu Yongnan;  Zhao Qingchun
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ENDOTHELIAL GROWTH-FACTOR  DRUG-INDUCED APOPTOSIS  HEMATOLOGICAL MALIGNANCIES  ACTIN REORGANIZATION  ANTICANCER DRUG  BONE-MARROW  KINASE AKT  CANCER  THALIDOMIDE  MIGRATION  isoindolone  anticancer drug  leukemia  zebrafish  angiogenesis  apoptosis  AKT  GSK3 beta  
Isoindolone derivative QSN-10c induces leukemic cell apoptosis and suppresses angiogenesis via PI3K/AKT signaling pathway inhibition 期刊论文
ACTA PHARMACOLOGICA SINICA, 2014, 卷号: 35, 期号: 5, 页码: 625-635
Authors:  Lv Wenwen;  Qin Sining;  Chen Congqin;  Zhang Jinjie;  Ren Tianshu;  Xu Yongnan;  Zhao Qingchun
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ENDOTHELIAL GROWTH-FACTOR  DRUG-INDUCED APOPTOSIS  HEMATOLOGICAL MALIGNANCIES  ACTIN REORGANIZATION  ANTICANCER DRUG  BONE-MARROW  KINASE AKT  CANCER  THALIDOMIDE  MIGRATION  isoindolone  anticancer drug  leukemia  zebrafish  angiogenesis  apoptosis  AKT  GSK3 beta  
Design, Synthesis and Anticancer Activity of Novel 6-(Aminophenyl)-2,4-bismorpholino-1,3,5-triazine Derivatives Bearing Arylmethylene Hydrazine Moiety 期刊论文
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES, 2014, 卷号: 30, 期号: 2, 页码: 257-265
Authors:  Huang Qiang;  Fu Qiangqiang;  Liu Yajing;  Bai Jinying;  Wang Qianying;  Liao Huimin;  Gong Ping
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POTENTIAL ANTITUMOR AGENTS  BIOLOGICAL EVALUATION  INHIBITOR  MTOR  Bis(morpholino-1,3,5-triazine)  Design  Anticancer activity  
A novel sulfonamide agent, MPSP-001, exhibits potent activity against human cancer cells in vitro through disruption of microtubule 期刊论文
ACTA PHARMACOLOGICA SINICA, 2012, 卷号: 33, 期号: 2, 页码: 261-270
Authors:  Liu Zulong;  Tian Wei;  Wang Yong;  Kuang Shan;  Luo Xiaomin;  Yu Qiang
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PHASE-I  ANTITUMOR-ACTIVITY  ANTICANCER AGENT  BINDING  APOPTOSIS  E7070  COLCHICINE  DISCOVERY  HMN-214  CAMPTOTHECIN  MPSP-001  sulfonamide  anticancer drug  microtubules  tubulin  mitotic spindle  drug resistance  drug synergism