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Discovery of a new series of imidazo1,2-apyridine compounds as selective c-Met inhibitors 期刊论文
ACTA PHARMACOLOGICA SINICA, 2016, 卷号: 37, 期号: 5, 页码: 698-707
Authors:  Liu Tongchao;  Peng Xia;  Ma Yuchi;  Ji Yinchun;  Chen Danqi;  Zheng Mingyue;  Zhao Dongmei;  Cheng Maosheng;  Geng Meiyu;  Shen Jingkang;  Ai Jing;  Xiong Bing
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RECEPTOR TYROSINE KINASE  INVASIVE GROWTH  SCATTER FACTOR  CANCER  DOCKING  c-Met inhibitors  hepatocyte growth factor receptor  imidazo1,2-apyridine  anticancer agents  drug discovery  
Discovery of a new series of imidazo1,2-apyridine compounds as selective c-Met inhibitors 期刊论文
ACTA PHARMACOLOGICA SINICA, 2016, 卷号: 37, 期号: 5, 页码: 698-707
Authors:  Liu Tongchao;  Peng Xia;  Ma Yuchi;  Ji Yinchun;  Chen Danqi;  Zheng Mingyue;  Zhao Dongmei;  Cheng Maosheng;  Geng Meiyu;  Shen Jingkang;  Ai Jing;  Xiong Bing
Favorite  |  View/Download:26/0  |  Submit date:2021/02/02
RECEPTOR TYROSINE KINASE  INVASIVE GROWTH  SCATTER FACTOR  CANCER  DOCKING  c-Met inhibitors  hepatocyte growth factor receptor  imidazo1,2-apyridine  anticancer agents  drug discovery  
Silibinin and indocyanine green-loaded nanoparticles inhibit the growth and metastasis of mammalian breast cancer cells in vitro 期刊论文
ACTA PHARMACOLOGICA SINICA, 2016, 卷号: 37, 期号: 7, 页码: 941-949
Authors:  Sun Huiping;  Su Jinghan;  Meng Qingshuo;  Yin Qi;  Zhang Zhiwen;  Yu Haijun;  Zhang Pengcheng;  Wang Siling;  Li Yaping
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COMBINATION THERAPY  POLYMERIC MICELLES  GOLD NANORODS  DOXORUBICIN  RELEASE  NANOMEDICINE  NANOCARRIER  PACLITAXEL  INVASION  DELIVERY  breast cancer  4T1 mammalian breast cancer cells  metastasis  nanoparticles  silibinin  photothermal therapy  NIR laser irradiation  
Echinacoside induces rat pulmonary artery vasorelaxation by opening the NO-cGMP-PKG-BKCa channels and reducing intracellular Ca2+ levels 期刊论文
ACTA PHARMACOLOGICA SINICA, 2015, 卷号: 36, 期号: 5, 页码: 587-596
Authors:  Gai Xiangyun;  Wei Yuhai;  Zhang Wei;  Wuren Tana;  Wang Yaping;  Li Zhanqiang;  Liu Shou;  Ma Lan;  Lu Dianxiang;  Zhou Yi;  Ge Rili
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ACTIVATED POTASSIUM CHANNELS  K+ CHANNELS  CALCIUM-CHANNEL  Tibetan herb  echinacoside  pulmonary hypertension  high altitude  vasorelaxation  NO  BKCa  K-IR  artery ring  pulmonary arterial smooth muscle cells  
Isoindolone derivative QSN-10c induces leukemic cell apoptosis and suppresses angiogenesis via PI3K/AKT signaling pathway inhibition 期刊论文
ACTA PHARMACOLOGICA SINICA, 2014, 卷号: 35, 期号: 5, 页码: 625-635
Authors:  Lv Wenwen;  Qin Sining;  Chen Congqin;  Zhang Jinjie;  Ren Tianshu;  Xu Yongnan;  Zhao Qingchun
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ENDOTHELIAL GROWTH-FACTOR  DRUG-INDUCED APOPTOSIS  HEMATOLOGICAL MALIGNANCIES  ACTIN REORGANIZATION  ANTICANCER DRUG  BONE-MARROW  KINASE AKT  CANCER  THALIDOMIDE  MIGRATION  isoindolone  anticancer drug  leukemia  zebrafish  angiogenesis  apoptosis  AKT  GSK3 beta  
Isoindolone derivative QSN-10c induces leukemic cell apoptosis and suppresses angiogenesis via PI3K/AKT signaling pathway inhibition 期刊论文
ACTA PHARMACOLOGICA SINICA, 2014, 卷号: 35, 期号: 5, 页码: 625-635
Authors:  Lv Wenwen;  Qin Sining;  Chen Congqin;  Zhang Jinjie;  Ren Tianshu;  Xu Yongnan;  Zhao Qingchun
Favorite  |  View/Download:27/0  |  Submit date:2021/02/02
ENDOTHELIAL GROWTH-FACTOR  DRUG-INDUCED APOPTOSIS  HEMATOLOGICAL MALIGNANCIES  ACTIN REORGANIZATION  ANTICANCER DRUG  BONE-MARROW  KINASE AKT  CANCER  THALIDOMIDE  MIGRATION  isoindolone  anticancer drug  leukemia  zebrafish  angiogenesis  apoptosis  AKT  GSK3 beta  
Inhibitory effects of rosiglitazone on paraquat-induced acute lung injury in rats 期刊论文
ACTA PHARMACOLOGICA SINICA, 2013, 卷号: 34, 期号: 10, 页码: 1317-1324
Authors:  Liu Zhenning;  Zhao Min;  Zheng Qiang;  Zhao Hongyu;  Hou Weijian;  Bai Shuling
Favorite  |  View/Download:25/0  |  Submit date:2021/02/02
ACTIVATED-RECEPTOR-GAMMA  NRF2 ENHANCES SUSCEPTIBILITY  INFLAMMATORY RESPONSE  LIPID-PEROXIDATION  MICE  PROTECTION  INTOXICATION  ANTIOXIDANTS  HETERODIMER  EXPRESSION  rosiglitazone  herbicide  paraquat  acute lung injury  PPAR-gamma  NF-kappa B  Nrf2  toxicity  
Inhibitory effects of rosiglitazone on paraquat-induced acute lung injury in rats 期刊论文
ACTA PHARMACOLOGICA SINICA, 2013, 卷号: 34, 期号: 10, 页码: 1317-1324
Authors:  Liu Zhenning;  Zhao Min;  Zheng Qiang;  Zhao Hongyu;  Hou Weijian;  Bai Shuling
Favorite  |  View/Download:25/0  |  Submit date:2021/02/02
ACTIVATED-RECEPTOR-GAMMA  NRF2 ENHANCES SUSCEPTIBILITY  INFLAMMATORY RESPONSE  LIPID-PEROXIDATION  MICE  PROTECTION  INTOXICATION  ANTIOXIDANTS  HETERODIMER  EXPRESSION  rosiglitazone  herbicide  paraquat  acute lung injury  PPAR-gamma  NF-kappa B  Nrf2  toxicity  
Energetic factors determining the binding of type I inhibitors to c-Met kinase: experimental studies and quantum mechanical calculations 期刊论文
ACTA PHARMACOLOGICA SINICA, 2013, 卷号: 34, 期号: 11, 页码: 1475-1483
Authors:  Yu Zhe;  Ma Yuchi;  Ai Jing;  Chen Danqi;  Zhao Dongmei;  Wang Xin;  Chen Yuelei;  Geng Meiyu;  Xiong Bing;  Cheng Maosheng;  Shen Jingkang
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SULFUR-PI INTERACTIONS  PERTURBATION-THEORY  SUBSTITUENTS  SANDWICH  BENZENE  PATHWAY  receptor tyrosine kinase  type I c-Met inhibitor  cancer  quantum chemistry  protein-ligand interaction  symmetry-adapted perturbation theory (SAPT)  
Energetic factors determining the binding of type I inhibitors to c-Met kinase: experimental studies and quantum mechanical calculations 期刊论文
ACTA PHARMACOLOGICA SINICA, 2013, 卷号: 34, 期号: 11, 页码: 1475-1483
Authors:  Yu Zhe;  Ma Yuchi;  Ai Jing;  Chen Danqi;  Zhao Dongmei;  Wang Xin;  Chen Yuelei;  Geng Meiyu;  Xiong Bing;  Cheng Maosheng;  Shen Jingkang
Favorite  |  View/Download:18/0  |  Submit date:2021/02/02
SULFUR-PI INTERACTIONS  PERTURBATION-THEORY  SUBSTITUENTS  SANDWICH  BENZENE  PATHWAY  receptor tyrosine kinase  type I c-Met inhibitor  cancer  quantum chemistry  protein-ligand interaction  symmetry-adapted perturbation theory (SAPT)