Study on Cytocompatability and Animal Implantation Test of Foam SiC
Wu Lin1; Xu Xing-Xiang2; Wang Lu-Zeng3; Rong Xiao-Fang1; Tian Chong2; Zhang Jin-Song2
Corresponding AuthorWu Lin(
AbstractFoam SiC was prepared by macromolecule pyrogenation combined with reaction bonding method. The osteoblast-like cells MG63 were seeded and cultured in vitro on the foam SIC and observed under both SEM and TEM to further evaluate the cytocompatability of this novel material. The feasibility of the foam SiC as a bone replacement material for clinical treatment was also studied by establishing an animal model for repairing mandibular critical-sized defects in rabbits, and by using general observation, histological observation and bone histomorphometry. The results show that MG63 cells attach and grow well on the surface of the foam SiC, which indicates that the foam SiC is non-toxic and possesses good cytocompatibility. The 26 tested rabbits are all in healthy conditions and the wounds are healed completely. The different degree of osteogenesis is observed on both periphery and inner mesh of the foam SIC at each time point, and the foam SiC shows no adverse effect to the process of bone repair. It is found that both the rate of tetracycline fluorescence labeling and the new bone area on the foam SIC are lower than those of hydroxyapatite (HA) after 4w implantation, but there are no statistical differences after both 8w and 24w implantations, indicating that the foam SiC should be similar to HA in osteo-conduction ability judging from the long-term repair effect to mandibular defects.
Keywordfoam SiC bone replacement material cell animal implantation
Indexed BySCI
WOS Research AreaMaterials Science
WOS SubjectMaterials Science, Ceramics
WOS IDWOS:000275254700020
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Cited Times:9[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorWu Lin
Affiliation1.China Med Univ, Sch Stomatol, Dept Prosthodont, Shenyang 110002, Peoples R China
2.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China
3.China Med Univ, Anim Test Ctr, Shenyang 110001, Peoples R China
Recommended Citation
GB/T 7714
Wu Lin,Xu Xing-Xiang,Wang Lu-Zeng,et al. Study on Cytocompatability and Animal Implantation Test of Foam SiC[J]. JOURNAL OF INORGANIC MATERIALS,2010,25(2):211-215.
APA Wu Lin,Xu Xing-Xiang,Wang Lu-Zeng,Rong Xiao-Fang,Tian Chong,&Zhang Jin-Song.(2010).Study on Cytocompatability and Animal Implantation Test of Foam SiC.JOURNAL OF INORGANIC MATERIALS,25(2),211-215.
MLA Wu Lin,et al."Study on Cytocompatability and Animal Implantation Test of Foam SiC".JOURNAL OF INORGANIC MATERIALS 25.2(2010):211-215.
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