| Non-genomic mechanism of glucocorticoid's rapid action on neurons-membrane receptor hypothesis |
| Chen, YZ; Hua, SY; Guo, Z; Fu, H; Wang, CA
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| 通讯作者 | Chen, YZ()
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| 1999-02-01
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| 发表期刊 | PROGRESS IN NATURAL SCIENCE-MATERIALS INTERNATIONAL
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| ISSN | 1002-0071
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| 卷号 | 9期号:2页码:81-87 |
| 摘要 | The genomic mechanism of steroid hormone action has been widely accepted in endocrinology. But there are difficulties in interpreting the rapid action of steroid hormone on nervous system. The non-genomic mode of glucocorticoid (GC) action was raised in 1987, which proposed that GC acted on the membrane receptor of the neuron. A series of experiments showed that through the non-genomic mechanism, GC could depress the excitability, inhibit the secretion, and augment the uptake of glutamate of neurons. The effects are mediated by the proposed membrane receptor of GC, the existence of which was substantiated by electrophysiological, biochemical, and morphological evidences. |
| 关键词 | membrane receptor
glucocorticoid
non-genomic mechanism
neuron
hypothesis
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| 收录类别 | SCI
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| 语种 | 英语
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| WOS研究方向 | Materials Science
; Science & Technology - Other Topics
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| WOS类目 | Materials Science, Multidisciplinary
; Multidisciplinary Sciences
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| WOS记录号 | WOS:000078393200001
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| 出版者 | ELSEVIER SCIENCE INC
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| 引用统计 |
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| 文献类型 | 期刊论文
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| 条目标识符 | http://ir.imr.ac.cn/handle/321006/109156
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| 专题 | 中国科学院金属研究所
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| 通讯作者 | Chen, YZ |
| 作者单位 | Second Mil Med Univ, Dept Physiol, Inst Neurosci, Shanghai 200433, Peoples R China
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推荐引用方式
GB/T 7714 |
Chen, YZ,Hua, SY,Guo, Z,et al. Non-genomic mechanism of glucocorticoid's rapid action on neurons-membrane receptor hypothesis[J]. PROGRESS IN NATURAL SCIENCE-MATERIALS INTERNATIONAL,1999,9(2):81-87.
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| APA |
Chen, YZ,Hua, SY,Guo, Z,Fu, H,&Wang, CA.(1999).Non-genomic mechanism of glucocorticoid's rapid action on neurons-membrane receptor hypothesis.PROGRESS IN NATURAL SCIENCE-MATERIALS INTERNATIONAL,9(2),81-87.
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| MLA |
Chen, YZ,et al."Non-genomic mechanism of glucocorticoid's rapid action on neurons-membrane receptor hypothesis".PROGRESS IN NATURAL SCIENCE-MATERIALS INTERNATIONAL 9.2(1999):81-87.
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