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A novel nano-copper-bearing stainless steel with reduced Cu2+ release only inducing transient foreign body reaction via affecting the activity of NF-kappa B and Caspase 3
Wang, Lei1; Ren, Ling2; Tang, Tingting1; Dai, Kerong1; Yang, Ke2; Hao, Yongqiang1
Corresponding AuthorHao, Yongqiang(hyq_9hospital@hotmail.com)
2015
Source PublicationINTERNATIONAL JOURNAL OF NANOMEDICINE
ISSN1178-2013
Volume10Pages:6725-6739
AbstractForeign body reaction induced by biomaterials is a serious problem in clinical applications. Although 317L-Cu stainless steel (317L-Cu SS) is a new type of implant material with antibacterial ability and osteogenic property, the foreign body reaction level still needs to be assessed due to its Cu2+ releasing property. For this purpose, two macrophage cell lines were selected to detect cellular proliferation, apoptosis, mobility, and the secretions of inflammatory cytokines with the influence of 317L-Cu SS. Our results indicated that 317L-Cu SS had no obvious effect on the proliferation and apoptosis of macrophages; however, it significantly increased cellular migration and TNF-alpha secretion. Then, C57 mice were used to assess foreign body reaction induced by 317L-Cu SS. We observed significantly enhanced recruitment of inflammatory cells (primarily macrophages) with increased TNF-alpha secretion and apoptosis level in tissues around the materials in the early stage of implantation. With tissue healing, both inflammation and apoptosis significantly decreased. Further, we discovered that NF-kappa B pathway and Caspase 3 played important roles in 317L-Cu SS induced inflammation and apoptosis. We concluded that 317L-Cu SS could briefly promote the inflammation and apoptosis of surrounding tissues by regulating the activity of NF-kappa B pathway and Caspase 3. All these discoveries demonstrated that 317L-Cu SS has a great potential for clinical application.
Keywordnano-copper foreign body reaction inflammation apoptosis NF-kappa B Caspase 3
Funding OrganizationKey National Basic Research Program of China ; National Natural Science Foundation of China ; Industry-University-Research-Medical Cooperation Project of the Science and Technology Commission of Shanghai ; New Cutting-Edge Technology Project of ShenKang Hospital Development Center of Shanghai ; Doctoral Innovation Fund Projects from Shanghai Jiao Tong University School of Medicine
DOI10.2147/IJN.S90249
Indexed BySCI
Language英语
Funding ProjectKey National Basic Research Program of China[2012CB619101] ; National Natural Science Foundation of China[81071472] ; National Natural Science Foundation of China[81371960] ; National Natural Science Foundation of China[81301329] ; Industry-University-Research-Medical Cooperation Project of the Science and Technology Commission of Shanghai[12DZ1940203] ; New Cutting-Edge Technology Project of ShenKang Hospital Development Center of Shanghai[SHDC12014124] ; Doctoral Innovation Fund Projects from Shanghai Jiao Tong University School of Medicine[BXJ201429]
WOS Research AreaScience & Technology - Other Topics ; Pharmacology & Pharmacy
WOS SubjectNanoscience & Nanotechnology ; Pharmacology & Pharmacy
WOS IDWOS:000363780300001
PublisherDOVE MEDICAL PRESS LTD
Citation statistics
Cited Times:11[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/121022
Collection中国科学院金属研究所
Corresponding AuthorHao, Yongqiang
Affiliation1.Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 9, Shanghai Key Lab Orthopaed Implants,Dept Orthopae, Shanghai 200011, Peoples R China
2.Chinese Acad Sci, Met Res Inst, Shenyang 110016, Peoples R China
Recommended Citation
GB/T 7714
Wang, Lei,Ren, Ling,Tang, Tingting,et al. A novel nano-copper-bearing stainless steel with reduced Cu2+ release only inducing transient foreign body reaction via affecting the activity of NF-kappa B and Caspase 3[J]. INTERNATIONAL JOURNAL OF NANOMEDICINE,2015,10:6725-6739.
APA Wang, Lei,Ren, Ling,Tang, Tingting,Dai, Kerong,Yang, Ke,&Hao, Yongqiang.(2015).A novel nano-copper-bearing stainless steel with reduced Cu2+ release only inducing transient foreign body reaction via affecting the activity of NF-kappa B and Caspase 3.INTERNATIONAL JOURNAL OF NANOMEDICINE,10,6725-6739.
MLA Wang, Lei,et al."A novel nano-copper-bearing stainless steel with reduced Cu2+ release only inducing transient foreign body reaction via affecting the activity of NF-kappa B and Caspase 3".INTERNATIONAL JOURNAL OF NANOMEDICINE 10(2015):6725-6739.
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