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A novel magnetic mesoporous silicon composite combining the function of magnetic target drug delivery and magnetic-induction hyperthermia
Zhang, Y.1; Zhang, Q.1,2; Che, E. X.1; Xia, D. D.1; Liu, Y. C.1; Li, D.3; Zhang, Z. D.3; Wang, S. L.1
Corresponding AuthorWang, S. L.(wangslsy@163.com)
2015
Source PublicationMATERIALS TECHNOLOGY
ISSN1066-7857
Volume30Issue:B4Pages:B211-B215
AbstractA magnetic mesoporous silicon (MMS) composite with magnetic particles as the core and mesoporous as the shell was prepared. The MMS composite was characterised by means of transmission electron microscopy (TEM), X-ray diffraction (XRD), and nitrogen adsorption. The MMS composite with the pore-size of 2 and 200 nm in diameter had a good application prospect in the magnetic-induction hyperthermia and drug delivery. The composite function of magnetic-induction hyperthermia was measured by a high-frequency-induction heating machine with the frequency 608 kHz and the field amplitude 6.4 kA m(-1). The magnetic mesoporous composite took about 7 min to heat up 45 degrees C with the average heating rate of 2.25 degrees C min(-1). The function of loading doxorubicin (DOX) hydrochloride was measured at 488 nm on a UV-Vis spectrophotometry, and the loading efficiency with 20.1% was achieved for the DOX hydrochloride being possibly loaded into the mesoporous. This result put MMS a way of the synchronised therapy of hyperthermia and magnetic target drug delivery.
KeywordMagnetic particles Mesoporous silicon Magnetic heat Synchronised therapy
Funding OrganizationNational Natural Foundation of China ; Doctor Start-up Program of Liao Ning Province
DOI10.1179/17535557B15Y.000000010
Indexed BySCI
Language英语
Funding ProjectNational Natural Foundation of China[81401501] ; Doctor Start-up Program of Liao Ning Province[20111136]
WOS Research AreaMaterials Science
WOS SubjectMaterials Science, Multidisciplinary
WOS IDWOS:000374566400004
PublisherTAYLOR & FRANCIS LTD
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/122183
Collection中国科学院金属研究所
Corresponding AuthorWang, S. L.
Affiliation1.Shen Yang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang Pharmaceut Univ, 103 Wenhua Rd, Shenyang 110016, Peoples R China
2.Jiangsu Hengrui Med Co Ltd, Lianyungang 222000, Peoples R China
3.Chinese Acad Sci, Int Ctr Mat Phys, Inst Met Res, Shenyang Natl Lab Mat Sci, Shenyang 110016, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Y.,Zhang, Q.,Che, E. X.,et al. A novel magnetic mesoporous silicon composite combining the function of magnetic target drug delivery and magnetic-induction hyperthermia[J]. MATERIALS TECHNOLOGY,2015,30(B4):B211-B215.
APA Zhang, Y..,Zhang, Q..,Che, E. X..,Xia, D. D..,Liu, Y. C..,...&Wang, S. L..(2015).A novel magnetic mesoporous silicon composite combining the function of magnetic target drug delivery and magnetic-induction hyperthermia.MATERIALS TECHNOLOGY,30(B4),B211-B215.
MLA Zhang, Y.,et al."A novel magnetic mesoporous silicon composite combining the function of magnetic target drug delivery and magnetic-induction hyperthermia".MATERIALS TECHNOLOGY 30.B4(2015):B211-B215.
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