Cellular-membrane inspired surface modification of well aligned ZnO nanorods for chemosensing of epinephrine

doi:10.1039/c6ra26250c

IMR OpenIR

	Cellular-membrane inspired surface modification of well aligned ZnO nanorods for chemosensing of epinephrine
	Mohsin, M. A.; Liu, B. D.; Zhang, X. L.; Yang, W. J.; Liu, L. S.; Jiang, X.
通讯作者	Liu, B. D.(baodanliu@hotmail.com) ; Jiang, X.(xjiang@imr.ac.cn)
	2017
发表期刊	RSC ADVANCES
ISSN	2046-2069
卷号	7 期号:5 页码:3012-3020
摘要	Neurological disorders have always triggered the interest of scientists due to the effects they have on the quality of life and the complexity they provide in their perception. Herein, we report a cellular-membrane inspired surface modification to fabricate a chemosensor for selective epinephrine detection. For this, well aligned ZnO nanorod arrays were grown on a silicon substrate using a feasible hydrothermal method and further utilized for the immobilization of a lipid membrane incorporated with calix[6]arene (in a 100 : 1 ratio) after modification with 1-octadecanthiol. Such surfaces were employed for selective epinephrine detection using electrochemical impedance spectroscopy as a transduction method. The detection process was based on the Lock & Key mechanism. A distinctive increase in charge transfer resistance was observed for epinephrine as compared to dopamine, leading to the conclusion that the sensor is sensitive and selective to epinephrine. This selectivity for epinephrine can be attributed to the slight differences in the molecular sizes of dopamine and epinephrine. Such electrochemical sensors can provide a very useful platform for the manufacturing of devices for monitoring the physiological concentrations of epinephrine.
资助者	Knowledge Innovation Program of Institute of Metal Research (IMR), Chinese Academy of Science (CAS) ; Youth Innovation Promotion Association, Chinese Academy of Sciences ; CAS President's International Fellowship for Postdoctoral Researchers
DOI	10.1039/c6ra26250c
收录类别	SCI
语种	英语
资助项目	Knowledge Innovation Program of Institute of Metal Research (IMR), Chinese Academy of Science (CAS)[Y2NCA111A1] ; Knowledge Innovation Program of Institute of Metal Research (IMR), Chinese Academy of Science (CAS)[Y3NCA111A1] ; Youth Innovation Promotion Association, Chinese Academy of Sciences[Y4NC711171] ; CAS President's International Fellowship for Postdoctoral Researchers[2015PM022]
WOS研究方向	Chemistry
WOS类目	Chemistry, Multidisciplinary
WOS记录号	WOS:000393748600072
出版者	ROYAL SOC CHEMISTRY
引用统计	被引频次：6[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/123721
专题	中国科学院金属研究所
通讯作者	Liu, B. D.; Jiang, X.
作者单位	Chinese Acad Sci, Shenyang Natl Lab Mat Sci SYNL, IMR, 72 Wenhua Rd, Shenyang 110016, Peoples R China
推荐引用方式 GB/T 7714	Mohsin, M. A.,Liu, B. D.,Zhang, X. L.,et al. Cellular-membrane inspired surface modification of well aligned ZnO nanorods for chemosensing of epinephrine[J]. RSC ADVANCES,2017,7(5):3012-3020.
APA	Mohsin, M. A.,Liu, B. D.,Zhang, X. L.,Yang, W. J.,Liu, L. S.,&Jiang, X..(2017).Cellular-membrane inspired surface modification of well aligned ZnO nanorods for chemosensing of epinephrine.RSC ADVANCES,7(5),3012-3020.
MLA	Mohsin, M. A.,et al."Cellular-membrane inspired surface modification of well aligned ZnO nanorods for chemosensing of epinephrine".RSC ADVANCES 7.5(2017):3012-3020.