Biodegradable magnesium wire promotes regeneration of compressed sciatic nerves

doi:10.4103/1673-5374.197146

IMR OpenIR

	Biodegradable magnesium wire promotes regeneration of compressed sciatic nerves
	Li, Bo-han 1,2; Yang, Ke 3; Wang, Xiao 4
通讯作者	Wang, Xiao(bysywangxiao@163.com)
	2016-12-01
发表期刊	NEURAL REGENERATION RESEARCH
ISSN	1673-5374
卷号	11 期号:12 页码:2012-2017
摘要	Magnesium (Mg) wire has been shown to be biodegradable and have anti-inflammatory properties. It can induce Schwann cells to secrete nerve growth factor and promote the regeneration of nerve axons after central nervous system injury. We hypothesized that biodegradable Mg wire may enhance compressed peripheral nerve regeneration. A rat acute sciatic nerve compression model was made, and AZ31 Mg wire (3 mm diameter; 8 mm length) bridged at both ends of the nerve. Our results demonstrate that sciatic functional index, nerve growth factor, p75 neurotrophin receptor, and tyrosine receptor kinase A mRNA expression are increased by Mg wire in Mg model. The numbers of cross section nerve fibers and regenerating axons were also increased. Sciatic nerve function was improved and the myelinated axon number was increased in injured sciatic nerve following Mg treatment. Immunofluorescence histopathology showed that there were increased vigorous axonal regeneration and myelin sheath coverage in injured sciatic nerve after Mg treatment. Our findings confirm that biodegradable Mg wire can promote the regeneration of acute compressed sciatic nerves.
关键词	nerve regeneration peripheral nerve regeneration biodegradable magnesium wire sciatic nerve rats nerve growth factor P75 neurotrophin receptor tyrosine receptor kinase A neural regeneration
资助者	National Natural Science Foundation of China ; China Postdoctoral Science Foundation
DOI	10.4103/1673-5374.197146
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[81400528] ; China Postdoctoral Science Foundation[20130390827]
WOS研究方向	Cell Biology ; Neurosciences & Neurology
WOS类目	Cell Biology ; Neurosciences
WOS记录号	WOS:000393890900029
出版者	MEDKNOW PUBLICATIONS & MEDIA PVT LTD
引用统计	被引频次：22[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/123759
专题	中国科学院金属研究所
通讯作者	Wang, Xiao
作者单位	1.Gen Hosp Peoples Liberat Army, Dept Oral Maxillofacial Surg, Beijing, Peoples R China 2.Binzhou Med Univ, Dept Oral Maxillofacial Surg, Yantai, Shandong, Peoples R China 3.Chinese Acad Sci, Met Res Inst, Shenyang, Liaoning Provin, Peoples R China 4.Peking Univ, Hosp 3, Dept Oral & Maxillofacial Surg, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Li, Bo-han,Yang, Ke,Wang, Xiao. Biodegradable magnesium wire promotes regeneration of compressed sciatic nerves[J]. NEURAL REGENERATION RESEARCH,2016,11(12):2012-2017.
APA	Li, Bo-han,Yang, Ke,&Wang, Xiao.(2016).Biodegradable magnesium wire promotes regeneration of compressed sciatic nerves.NEURAL REGENERATION RESEARCH,11(12),2012-2017.
MLA	Li, Bo-han,et al."Biodegradable magnesium wire promotes regeneration of compressed sciatic nerves".NEURAL REGENERATION RESEARCH 11.12(2016):2012-2017.