| Research of Biodegradable Mg-Based Metals as Bone Graft Substitutes | |
| Dong Jiahui1,2; Tan Lili1; Yang Ke1 | |
| Corresponding Author | Yang Ke(kyang@imr.ac.cn) |
| 2017-10-11 | |
| Source Publication | ACTA METALLURGICA SINICA
 |
| ISSN | 0412-1961 |
| Volume | 53Issue:10Pages:1197-1206 |
| Abstract | Bone defects are very challenging in orthopedic practice due to a variety of reasons. Bone repair requires four critical elements, biocompatibility, osteoconduction, osteoinduction and osteogenesis. The autografts still exist some problems for applications such as the limitation of available autogenous bones and post-operative complications, although they are considered as the "gold standard" in bony defect repairs. Generally the synthetic bone substitutes do not possess osteoinductive and osteogenic activities. Therefore, the clinical bone grafts and bone-graft substitutes have their own shortcomings in the repair of bone defects. Biodegradable magnesium-based metals, including pure magnesium and magnesium alloys, have been concerned and studied recently due to their biodegradation, good biocompatibility and similar elastic modulus and density with bone tissue. This paper summarizes the biological behavior of magnesium-based metals for bone defects repair application, including ability of promoting osteogenesis, osteoconduction and potential osteoinduction, as well as some particular biofunctions such as antibacterial and antitumor properties. The great advantages and potentials of magnesium in bone defects repair can not be denied as a promising class of bone substitutes, although further researches are still needed for clinical applications. |
| Keyword | bone defect bone repair osteogenesis Mg-based metal biodegradable |
| Funding Organization | National Natural Science Foundation of China |
| DOI | 10.11900/0412.1961.2017.00279 |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | National Natural Science Foundation of China[81401773] ; National Natural Science Foundation of China[31500777] |
| WOS Research Area | Metallurgy & Metallurgical Engineering |
| WOS Subject | Metallurgy & Metallurgical Engineering |
| WOS ID | WOS:000416301400005 |
| Publisher | SCIENCE PRESS |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/125454 |
| Collection | 中国科学院金属研究所 |
| Corresponding Author | Yang Ke |
| Affiliation | 1.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Liaoning, Peoples R China 2.Univ Sci & Technol China, Sch Mat Sci & Engn, Shenyang 110016, Liaoning, Peoples R China |
| Recommended Citation GB/T 7714 | Dong Jiahui,Tan Lili,Yang Ke. Research of Biodegradable Mg-Based Metals as Bone Graft Substitutes[J]. ACTA METALLURGICA SINICA,2017,53(10):1197-1206. |
| APA | Dong Jiahui,Tan Lili,&Yang Ke.(2017).Research of Biodegradable Mg-Based Metals as Bone Graft Substitutes.ACTA METALLURGICA SINICA,53(10),1197-1206. |
| MLA | Dong Jiahui,et al."Research of Biodegradable Mg-Based Metals as Bone Graft Substitutes".ACTA METALLURGICA SINICA 53.10(2017):1197-1206. |
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