Research of Biodegradable Mg-Based Metals as Bone Graft Substitutes
Dong Jiahui1,2; Tan Lili1; Yang Ke1
Corresponding AuthorYang Ke(
AbstractBone defects are very challenging in orthopedic practice due to a variety of reasons. Bone repair requires four critical elements, biocompatibility, osteoconduction, osteoinduction and osteogenesis. The autografts still exist some problems for applications such as the limitation of available autogenous bones and post-operative complications, although they are considered as the "gold standard" in bony defect repairs. Generally the synthetic bone substitutes do not possess osteoinductive and osteogenic activities. Therefore, the clinical bone grafts and bone-graft substitutes have their own shortcomings in the repair of bone defects. Biodegradable magnesium-based metals, including pure magnesium and magnesium alloys, have been concerned and studied recently due to their biodegradation, good biocompatibility and similar elastic modulus and density with bone tissue. This paper summarizes the biological behavior of magnesium-based metals for bone defects repair application, including ability of promoting osteogenesis, osteoconduction and potential osteoinduction, as well as some particular biofunctions such as antibacterial and antitumor properties. The great advantages and potentials of magnesium in bone defects repair can not be denied as a promising class of bone substitutes, although further researches are still needed for clinical applications.
Keywordbone defect bone repair osteogenesis Mg-based metal biodegradable
Funding OrganizationNational Natural Science Foundation of China
Indexed BySCI
Funding ProjectNational Natural Science Foundation of China[81401773] ; National Natural Science Foundation of China[31500777]
WOS Research AreaMetallurgy & Metallurgical Engineering
WOS SubjectMetallurgy & Metallurgical Engineering
WOS IDWOS:000416301400005
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorYang Ke
Affiliation1.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Liaoning, Peoples R China
2.Univ Sci & Technol China, Sch Mat Sci & Engn, Shenyang 110016, Liaoning, Peoples R China
Recommended Citation
GB/T 7714
Dong Jiahui,Tan Lili,Yang Ke. Research of Biodegradable Mg-Based Metals as Bone Graft Substitutes[J]. ACTA METALLURGICA SINICA,2017,53(10):1197-1206.
APA Dong Jiahui,Tan Lili,&Yang Ke.(2017).Research of Biodegradable Mg-Based Metals as Bone Graft Substitutes.ACTA METALLURGICA SINICA,53(10),1197-1206.
MLA Dong Jiahui,et al."Research of Biodegradable Mg-Based Metals as Bone Graft Substitutes".ACTA METALLURGICA SINICA 53.10(2017):1197-1206.
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