| Photodynamic properties of a bispyrrolecarboxamide-modified hypocrellin B: The role of affinity and ascorbic acid | |
| Liu, Yanyan1,2; Zhou, Qianxiong1,2; Zeng, Zhanghua1,2; Qiao, Rui1,2; Wang, Xuesong1; Zhang, Baowen1 | |
| Corresponding Author | Zhang, Baowen(g203@mail.ipc.ac.cn) |
| 2008-08-14 | |
| Source Publication | JOURNAL OF PHYSICAL CHEMISTRY B
 |
| ISSN | 1520-6106 |
| Volume | 112Issue:32Pages:9959-9965 |
| Abstract | The photodynamic properties of a new hypocrellin B (HB) derivative bearing a bispyrrolecarboxamide pendant (HB-Net) were investigated in detail. EPR experiments revealed that the generation ability of reactive oxygen species (ROS) of HB-Net is inferior to that of HB. DNA melting temperature measurements and ethidium bromide (EB) displacement assay illustrated the affinity of HB-Net toward dsDNA as the result of the bispyrrolecarboxamide unit, which is structurally related to the well-known minor groove binder netropsin. The radical generation abilities of HB and HB-Net can be enhanced by ascorbic acid via the photoinduced electron transfer from ascorbic acid to the photosensitizer, however, only the DNA photodamage capability of HB-Net can be improved significantly by ascorbic acid due to the stronger affinity of HB-Net to DNA. Consequently, the combination of HB-Net and ascorbic acid may lead to efficient DNA photodamage even in anaerobic conditions. |
| DOI | 10.1021/jp7121467 |
| Indexed By | SCI |
| Language | 英语 |
| WOS Research Area | Chemistry |
| WOS Subject | Chemistry, Physical |
| WOS ID | WOS:000258290000048 |
| Publisher | AMER CHEMICAL SOC |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/126283 |
| Collection | 中国科学院金属研究所 |
| Corresponding Author | Zhang, Baowen |
| Affiliation | 1.Chinese Acad Sci, Key Lab Photochem Convers & Optoelect Mat, Tech Inst Phys & Chem, Beijing 100190, Peoples R China 2.Grad Sch Chinese Acad Sci, Beijing 100049, Peoples R China |
| Recommended Citation GB/T 7714 | Liu, Yanyan,Zhou, Qianxiong,Zeng, Zhanghua,et al. Photodynamic properties of a bispyrrolecarboxamide-modified hypocrellin B: The role of affinity and ascorbic acid[J]. JOURNAL OF PHYSICAL CHEMISTRY B,2008,112(32):9959-9965. |
| APA | Liu, Yanyan,Zhou, Qianxiong,Zeng, Zhanghua,Qiao, Rui,Wang, Xuesong,&Zhang, Baowen.(2008).Photodynamic properties of a bispyrrolecarboxamide-modified hypocrellin B: The role of affinity and ascorbic acid.JOURNAL OF PHYSICAL CHEMISTRY B,112(32),9959-9965. |
| MLA | Liu, Yanyan,et al."Photodynamic properties of a bispyrrolecarboxamide-modified hypocrellin B: The role of affinity and ascorbic acid".JOURNAL OF PHYSICAL CHEMISTRY B 112.32(2008):9959-9965. |
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