| Nanodiamonds as intracellular transporters of chemotherapeutic drug | |
| Li, Jing1,2; Zhu, Ying1; Li, Wenxin1; Zhang, Xiaoyong1,2; Peng, Yan3; Huang, Qing1 | |
| Corresponding Author | Li, Wenxin(liwenxin@sinap.ac.cn) |
| 2010-11-01 | |
| Source Publication | BIOMATERIALS
 |
| ISSN | 0142-9612 |
| Volume | 31Issue:32Pages:8410-8418 |
| Abstract | To explore the application of nanodiamonds (NDs) as anticancer drug delivery vehicles, firstly we examined the toxicity of NDs to three kinds of mammalian cells. The studies indicated that serum proteins in cell culture medium had significant effect. When cells were exposed to NDs dispersed in complete cell culture medium, no cytotoxicity was detected. However, severe cell death was found after exposed to NDs dispersed in serum-free medium. Possible reasons for serum-dependent cytotoxicity were discussed and the potential influence of serum on the test of efficacy was pointed for anticancer drug delivery system based on NDs. Then adsorption of anticancer drug 10-hydroxycamptothecin (HCPT) by NDs was studied. Experiments indicated that diluted NaOH solution could promote the loading of HCPT on NDs. And a slow release of HCPT from the HCPT-ND complex was established in low pH media. Assessments of cell viability and imaging with transmission electron microscopy demonstrated a much higher efficacy of the HCPT-ND complex compared with HCPT alone. On the basis of adsorption feature of ND aggregates, new strategy for the design of targeting drug delivery systems of NDs was proposed. (C) 2010 Elsevier Ltd. All rights reserved. |
| Keyword | Nanodiamonds Cytotoxicity Serum proteins Drug delivery Hydroxycamptothecin (HCPT) |
| Funding Organization | National Science Foundation of China ; Shanghai Municipal Natural Science Foundation ; Ministry of Health ; CAS ; MOST973 Program |
| DOI | 10.1016/j.biomaterials.2010.07.058 |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | National Science Foundation of China[10775169] ; National Science Foundation of China[10905086] ; National Science Foundation of China[10975179] ; National Science Foundation of China[90913014] ; Shanghai Municipal Natural Science Foundation[08ZR1422700] ; Shanghai Municipal Natural Science Foundation[08JC1422600] ; Ministry of Health[2009ZX10004-301] ; CAS[095501K] ; MOST973 Program[2006CB705605] ; MOST973 Program[2007CB936000] |
| WOS Research Area | Engineering ; Materials Science |
| WOS Subject | Engineering, Biomedical ; Materials Science, Biomaterials |
| WOS ID | WOS:000283112700032 |
| Publisher | ELSEVIER SCI LTD |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/126385 |
| Collection | 中国科学院金属研究所 |
| Corresponding Author | Li, Wenxin |
| Affiliation | 1.Chinese Acad Sci, Shanghai Inst Appl Phys, Phys Biol Lab, Shanghai 201800, Peoples R China 2.Grad Sch Chinese Acad Sci, Beijing 100049, Peoples R China 3.Gansu Gold Stone Nano Mat Co Ltd, Lanzhou 730000, Peoples R China |
| Recommended Citation GB/T 7714 | Li, Jing,Zhu, Ying,Li, Wenxin,et al. Nanodiamonds as intracellular transporters of chemotherapeutic drug[J]. BIOMATERIALS,2010,31(32):8410-8418. |
| APA | Li, Jing,Zhu, Ying,Li, Wenxin,Zhang, Xiaoyong,Peng, Yan,&Huang, Qing.(2010).Nanodiamonds as intracellular transporters of chemotherapeutic drug.BIOMATERIALS,31(32),8410-8418. |
| MLA | Li, Jing,et al."Nanodiamonds as intracellular transporters of chemotherapeutic drug".BIOMATERIALS 31.32(2010):8410-8418. |
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