Nanodiamonds as intracellular transporters of chemotherapeutic drug
Li, Jing1,2; Zhu, Ying1; Li, Wenxin1; Zhang, Xiaoyong1,2; Peng, Yan3; Huang, Qing1
Corresponding AuthorLi, Wenxin(
Source PublicationBIOMATERIALS
AbstractTo explore the application of nanodiamonds (NDs) as anticancer drug delivery vehicles, firstly we examined the toxicity of NDs to three kinds of mammalian cells. The studies indicated that serum proteins in cell culture medium had significant effect. When cells were exposed to NDs dispersed in complete cell culture medium, no cytotoxicity was detected. However, severe cell death was found after exposed to NDs dispersed in serum-free medium. Possible reasons for serum-dependent cytotoxicity were discussed and the potential influence of serum on the test of efficacy was pointed for anticancer drug delivery system based on NDs. Then adsorption of anticancer drug 10-hydroxycamptothecin (HCPT) by NDs was studied. Experiments indicated that diluted NaOH solution could promote the loading of HCPT on NDs. And a slow release of HCPT from the HCPT-ND complex was established in low pH media. Assessments of cell viability and imaging with transmission electron microscopy demonstrated a much higher efficacy of the HCPT-ND complex compared with HCPT alone. On the basis of adsorption feature of ND aggregates, new strategy for the design of targeting drug delivery systems of NDs was proposed. (C) 2010 Elsevier Ltd. All rights reserved.
KeywordNanodiamonds Cytotoxicity Serum proteins Drug delivery Hydroxycamptothecin (HCPT)
Funding OrganizationNational Science Foundation of China ; Shanghai Municipal Natural Science Foundation ; Ministry of Health ; CAS ; MOST973 Program
Indexed BySCI
Funding ProjectNational Science Foundation of China[10775169] ; National Science Foundation of China[10905086] ; National Science Foundation of China[10975179] ; National Science Foundation of China[90913014] ; Shanghai Municipal Natural Science Foundation[08ZR1422700] ; Shanghai Municipal Natural Science Foundation[08JC1422600] ; Ministry of Health[2009ZX10004-301] ; CAS[095501K] ; MOST973 Program[2006CB705605] ; MOST973 Program[2007CB936000]
WOS Research AreaEngineering ; Materials Science
WOS SubjectEngineering, Biomedical ; Materials Science, Biomaterials
WOS IDWOS:000283112700032
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Cited Times:169[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorLi, Wenxin
Affiliation1.Chinese Acad Sci, Shanghai Inst Appl Phys, Phys Biol Lab, Shanghai 201800, Peoples R China
2.Grad Sch Chinese Acad Sci, Beijing 100049, Peoples R China
3.Gansu Gold Stone Nano Mat Co Ltd, Lanzhou 730000, Peoples R China
Recommended Citation
GB/T 7714
Li, Jing,Zhu, Ying,Li, Wenxin,et al. Nanodiamonds as intracellular transporters of chemotherapeutic drug[J]. BIOMATERIALS,2010,31(32):8410-8418.
APA Li, Jing,Zhu, Ying,Li, Wenxin,Zhang, Xiaoyong,Peng, Yan,&Huang, Qing.(2010).Nanodiamonds as intracellular transporters of chemotherapeutic drug.BIOMATERIALS,31(32),8410-8418.
MLA Li, Jing,et al."Nanodiamonds as intracellular transporters of chemotherapeutic drug".BIOMATERIALS 31.32(2010):8410-8418.
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