| Toxicokinetics of short-chain chlorinated paraffins in Sprague-Dawley rats following single oral administration | |
| Geng, Ningbo1,2; Zhang, Haijun1; Xing, Liguo3; Gao, Yuan1; Zhang, Baoqin1; Wang, Feidi1,2; Ren, Xiaoqian1,2; Chen, Jiping1 | |
| Corresponding Author | Zhang, Haijun(hjzhang@dicp.ac.cn) ; Chen, Jiping(chenjp@dicp.ac.cn) |
| 2016-02-01 | |
| Source Publication | CHEMOSPHERE
 |
| ISSN | 0045-6535 |
| Volume | 145Pages:106-111 |
| Abstract | Short-chain chlorinated paraffins (SCCPs) have attracted considerable attention for their characteristic of persistent organic pollutants. However, very limited information is available for their toxicokinetic characteristics, limiting the evaluation of their health risks. In this study, we performed a toxicokinetics study to explore the absorption and excretion processes of SCCPs (a mixture of C-10-, C-11-, C-12- and C-13- CPs) after a single oral administration to the Sprague Dawley rats. The toxicokinetic results showed that peak blood concentration of total SCCPs was attained at 2.8 day with C-max value of 2.3 mg L-1. The half-lives of total SCCPs in blood for the absorption t(1/2) (ka), distribution t(1/2) (alpha) and elimination phases t(1/2) (beta) were calculated to be 1.0,1.7 and 6.6 days, respectively. During the 28 days post-dosing, about 27.9% and 3.5% of orally administrated SCCPs were excreted through feces and urine without metabolism, respectively. Congener group abundance profiles indicate a relative increase of Cl-5-SCCPs in blood and urine in the elimination stage, and a higher accumulation of Cl8-10-SCCPs in feces. The distribution discrepancies of SCCPs congener groups in blood and excreta were more dependent on chlorine contents than on carbon chain lengths. (C) 2015 Elsevier Ltd. All rights reserved. |
| Keyword | SCCPs Toxicokinetics Rat Half-life Blood |
| Funding Organization | National Natural Science Foundation of China ; National High Tech RD Plan |
| DOI | 10.1016/j.chemosphere.2015.11.066 |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | National Natural Science Foundation of China[21277141] ; National Natural Science Foundation of China[21337002] ; National High Tech RD Plan[2013AA065203] |
| WOS Research Area | Environmental Sciences & Ecology |
| WOS Subject | Environmental Sciences |
| WOS ID | WOS:000369196300014 |
| Publisher | PERGAMON-ELSEVIER SCIENCE LTD |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/126952 |
| Collection | 中国科学院金属研究所 |
| Corresponding Author | Zhang, Haijun; Chen, Jiping |
| Affiliation | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China 2.Grad Sch Chinese Acad Sci, Beijing 100049, Peoples R China 3.Safety Evaluat Ctr Shenyang Res Inst Chem Ind Ltd, Shenyang 110021, Peoples R China |
| Recommended Citation GB/T 7714 | Geng, Ningbo,Zhang, Haijun,Xing, Liguo,et al. Toxicokinetics of short-chain chlorinated paraffins in Sprague-Dawley rats following single oral administration[J]. CHEMOSPHERE,2016,145:106-111. |
| APA | Geng, Ningbo.,Zhang, Haijun.,Xing, Liguo.,Gao, Yuan.,Zhang, Baoqin.,...&Chen, Jiping.(2016).Toxicokinetics of short-chain chlorinated paraffins in Sprague-Dawley rats following single oral administration.CHEMOSPHERE,145,106-111. |
| MLA | Geng, Ningbo,et al."Toxicokinetics of short-chain chlorinated paraffins in Sprague-Dawley rats following single oral administration".CHEMOSPHERE 145(2016):106-111. |
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