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Toxicokinetics of short-chain chlorinated paraffins in Sprague-Dawley rats following single oral administration
Geng, Ningbo1,2; Zhang, Haijun1; Xing, Liguo3; Gao, Yuan1; Zhang, Baoqin1; Wang, Feidi1,2; Ren, Xiaoqian1,2; Chen, Jiping1
Corresponding AuthorZhang, Haijun(hjzhang@dicp.ac.cn) ; Chen, Jiping(chenjp@dicp.ac.cn)
2016-02-01
Source PublicationCHEMOSPHERE
ISSN0045-6535
Volume145Pages:106-111
AbstractShort-chain chlorinated paraffins (SCCPs) have attracted considerable attention for their characteristic of persistent organic pollutants. However, very limited information is available for their toxicokinetic characteristics, limiting the evaluation of their health risks. In this study, we performed a toxicokinetics study to explore the absorption and excretion processes of SCCPs (a mixture of C-10-, C-11-, C-12- and C-13- CPs) after a single oral administration to the Sprague Dawley rats. The toxicokinetic results showed that peak blood concentration of total SCCPs was attained at 2.8 day with C-max value of 2.3 mg L-1. The half-lives of total SCCPs in blood for the absorption t(1/2) (ka), distribution t(1/2) (alpha) and elimination phases t(1/2) (beta) were calculated to be 1.0,1.7 and 6.6 days, respectively. During the 28 days post-dosing, about 27.9% and 3.5% of orally administrated SCCPs were excreted through feces and urine without metabolism, respectively. Congener group abundance profiles indicate a relative increase of Cl-5-SCCPs in blood and urine in the elimination stage, and a higher accumulation of Cl8-10-SCCPs in feces. The distribution discrepancies of SCCPs congener groups in blood and excreta were more dependent on chlorine contents than on carbon chain lengths. (C) 2015 Elsevier Ltd. All rights reserved.
KeywordSCCPs Toxicokinetics Rat Half-life Blood
Funding OrganizationNational Natural Science Foundation of China ; National High Tech RD Plan
DOI10.1016/j.chemosphere.2015.11.066
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[21277141] ; National Natural Science Foundation of China[21337002] ; National High Tech RD Plan[2013AA065203]
WOS Research AreaEnvironmental Sciences & Ecology
WOS SubjectEnvironmental Sciences
WOS IDWOS:000369196300014
PublisherPERGAMON-ELSEVIER SCIENCE LTD
Citation statistics
Cited Times:23[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/126952
Collection中国科学院金属研究所
Corresponding AuthorZhang, Haijun; Chen, Jiping
Affiliation1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
2.Grad Sch Chinese Acad Sci, Beijing 100049, Peoples R China
3.Safety Evaluat Ctr Shenyang Res Inst Chem Ind Ltd, Shenyang 110021, Peoples R China
Recommended Citation
GB/T 7714
Geng, Ningbo,Zhang, Haijun,Xing, Liguo,et al. Toxicokinetics of short-chain chlorinated paraffins in Sprague-Dawley rats following single oral administration[J]. CHEMOSPHERE,2016,145:106-111.
APA Geng, Ningbo.,Zhang, Haijun.,Xing, Liguo.,Gao, Yuan.,Zhang, Baoqin.,...&Chen, Jiping.(2016).Toxicokinetics of short-chain chlorinated paraffins in Sprague-Dawley rats following single oral administration.CHEMOSPHERE,145,106-111.
MLA Geng, Ningbo,et al."Toxicokinetics of short-chain chlorinated paraffins in Sprague-Dawley rats following single oral administration".CHEMOSPHERE 145(2016):106-111.
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