Toxicokinetics of short-chain chlorinated paraffins in Sprague-Dawley rats following single oral administration

doi:10.1016/j.chemosphere.2015.11.066

IMR OpenIR

	Toxicokinetics of short-chain chlorinated paraffins in Sprague-Dawley rats following single oral administration
	Geng, Ningbo 1,2; Zhang, Haijun 1; Xing, Liguo 3; Gao, Yuan 1; Zhang, Baoqin 1; Wang, Feidi 1,2; Ren, Xiaoqian 1,2; Chen, Jiping 1
通讯作者	Zhang, Haijun(hjzhang@dicp.ac.cn) ; Chen, Jiping(chenjp@dicp.ac.cn)
	2016-02-01
发表期刊	CHEMOSPHERE
ISSN	0045-6535
卷号	145 页码:106-111
摘要	Short-chain chlorinated paraffins (SCCPs) have attracted considerable attention for their characteristic of persistent organic pollutants. However, very limited information is available for their toxicokinetic characteristics, limiting the evaluation of their health risks. In this study, we performed a toxicokinetics study to explore the absorption and excretion processes of SCCPs (a mixture of C-10-, C-11-, C-12- and C-13- CPs) after a single oral administration to the Sprague Dawley rats. The toxicokinetic results showed that peak blood concentration of total SCCPs was attained at 2.8 day with C-max value of 2.3 mg L-1. The half-lives of total SCCPs in blood for the absorption t(1/2) (ka), distribution t(1/2) (alpha) and elimination phases t(1/2) (beta) were calculated to be 1.0,1.7 and 6.6 days, respectively. During the 28 days post-dosing, about 27.9% and 3.5% of orally administrated SCCPs were excreted through feces and urine without metabolism, respectively. Congener group abundance profiles indicate a relative increase of Cl-5-SCCPs in blood and urine in the elimination stage, and a higher accumulation of Cl8-10-SCCPs in feces. The distribution discrepancies of SCCPs congener groups in blood and excreta were more dependent on chlorine contents than on carbon chain lengths. (C) 2015 Elsevier Ltd. All rights reserved.
关键词	SCCPs Toxicokinetics Rat Half-life Blood
资助者	National Natural Science Foundation of China ; National High Tech RD Plan
DOI	10.1016/j.chemosphere.2015.11.066
收录类别	SCI
语种	英语
资助项目	National Natural Science Foundation of China[21277141] ; National Natural Science Foundation of China[21337002] ; National High Tech RD Plan[2013AA065203]
WOS研究方向	Environmental Sciences & Ecology
WOS类目	Environmental Sciences
WOS记录号	WOS:000369196300014
出版者	PERGAMON-ELSEVIER SCIENCE LTD
引用统计	被引频次：36[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/126952
专题	中国科学院金属研究所
通讯作者	Zhang, Haijun; Chen, Jiping
作者单位	1.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China 2.Grad Sch Chinese Acad Sci, Beijing 100049, Peoples R China 3.Safety Evaluat Ctr Shenyang Res Inst Chem Ind Ltd, Shenyang 110021, Peoples R China
推荐引用方式 GB/T 7714	Geng, Ningbo,Zhang, Haijun,Xing, Liguo,et al. Toxicokinetics of short-chain chlorinated paraffins in Sprague-Dawley rats following single oral administration[J]. CHEMOSPHERE,2016,145:106-111.
APA	Geng, Ningbo.,Zhang, Haijun.,Xing, Liguo.,Gao, Yuan.,Zhang, Baoqin.,...&Chen, Jiping.(2016).Toxicokinetics of short-chain chlorinated paraffins in Sprague-Dawley rats following single oral administration.CHEMOSPHERE,145,106-111.
MLA	Geng, Ningbo,et al."Toxicokinetics of short-chain chlorinated paraffins in Sprague-Dawley rats following single oral administration".CHEMOSPHERE 145(2016):106-111.