Research on rat's pulmonary acute injury induced by lunar soil simulant

doi:10.1016/j.jcma.2016.10.016

IMR OpenIR

	Research on rat's pulmonary acute injury induced by lunar soil simulant
	Sun, Yan 1,2; Liu, Jin-Guo 2; Zheng, Yong-Chun 3; Xiao, Chun-Ling 1; Wan, Bing 4; Guo, Li 1; Wang, Xu-Guang 1; Bo, Wei 1
通讯作者	Sun, Yan(inksun@163.com)
	2018-02-01
发表期刊	JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
ISSN	1726-4901
卷号	81 期号:2 页码:133-140
摘要	Background: The steps to the moon never stopped after the Apollo Project. Lessons from manned landings on the moon have shown that lunar dust has great influence on the health of astronauts. In this paper, comparative studies between the lunar soil simulant (LSS) and PM2.5 were performed to discover their harm to human biological systems and explore the methods of prevention and treatment of dust poisoning for future lunar manned landings. Methods: Rats were randomly divided into the control group, two CAS-1 lunar soil simulant groups (tracheal perfusion with 7 mg and 0.7 mg, respectively, in a 1-mL volume) and the PM2.5 group (tracheal perfusion with 0.7 mg in a 1-mL volume). The biochemical indicators in the bronchoalveolar lavage fluid (BALF), MPO activity in the lung tissue, pathologic changes, and inflammatory cells in the BALF were measured after 4 h and 24 h. Results: The LSS group showed cytotoxicity that was closely related to the concentration. The figures of the two LSS groups (4 and 24 h) show that the alveolar septa were thickened. Additionally, it was observed that neutrophils had infiltrated, and various levels of inflammation occurred around the vascular and bronchial structures. Conclusion: The overall results of the acute effects of the lungs caused by dust showed that the lung toxicity of LSS was greater than that of PM2.5. LSS could induce lung damage and inflammatory lesions. The biomarkers in BALF caused by acute injury were consistent with his-topathologi c observations. Copyright (C) 2017, the Chinese Medical Association. Published by Elsevier Taiwan LLC.
关键词	Acute injury Lunar soil simulant Lung Rat
资助者	Science and Technology Research Fund of Shenyang Medical College ; Doctoral Scientific Research Fund of Liaoning Provincial Science and Technology Department ; National Science Foundation of China ; Research Fund of China Manned Space Engineering ; Science and Technology Development Fund of Macau
DOI	10.1016/j.jcma.2016.10.016
收录类别	SCI
语种	英语
资助项目	Science and Technology Research Fund of Shenyang Medical College[20171020] ; Doctoral Scientific Research Fund of Liaoning Provincial Science and Technology Department[20170520437] ; National Science Foundation of China[51775541] ; Research Fund of China Manned Space Engineering[030201] ; Science and Technology Development Fund of Macau[020/2014/A1]
WOS研究方向	General & Internal Medicine
WOS类目	Medicine, General & Internal
WOS记录号	WOS:000425706600008
出版者	ELSEVIER TAIWAN
引用统计	被引频次：14[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://ir.imr.ac.cn/handle/321006/127339
专题	中国科学院金属研究所
通讯作者	Sun, Yan
作者单位	1.Shenyang Med Coll, Huanghebei St 146, Shenyang, Liaoning, Peoples R China 2.Chinese Acad Sci, Shenyang Inst Automat, State Key Lab Robot, Shenyang, Liaoning, Peoples R China 3.Chinese Acad Sci, Natl Astron Observ, Beijing, Peoples R China 4.Shenyang Med Coll, Cent Hosp, Lab Med, Shenyang, Liaoning, Peoples R China
推荐引用方式 GB/T 7714	Sun, Yan,Liu, Jin-Guo,Zheng, Yong-Chun,et al. Research on rat's pulmonary acute injury induced by lunar soil simulant[J]. JOURNAL OF THE CHINESE MEDICAL ASSOCIATION,2018,81(2):133-140.
APA	Sun, Yan.,Liu, Jin-Guo.,Zheng, Yong-Chun.,Xiao, Chun-Ling.,Wan, Bing.,...&Bo, Wei.(2018).Research on rat's pulmonary acute injury induced by lunar soil simulant.JOURNAL OF THE CHINESE MEDICAL ASSOCIATION,81(2),133-140.
MLA	Sun, Yan,et al."Research on rat's pulmonary acute injury induced by lunar soil simulant".JOURNAL OF THE CHINESE MEDICAL ASSOCIATION 81.2(2018):133-140.