| Novel Water Soluble Chitosan Derivatives with 1,2,3-Triazolium and Their Free Radical-Scavenging Activity | |
| Li, Qing1; Sun, Xueqi1,2; Gu, Guodong3; Guo, Zhanyong1 | |
| Corresponding Author | Guo, Zhanyong(zhanyongguo@hotmail.com) |
| 2018-04-01 | |
| Source Publication | MARINE DRUGS
 |
| ISSN | 1660-3397 |
| Volume | 16Issue:4Pages:13 |
| Abstract | Chitosan is an abundant and renewable polysaccharide, which exhibits attractive bioactivities and natural properties. Improvement such as chemical modification of chitosan is often performed for its potential of providing high bioactivity and good water solubility. A new class of chitosan derivatives possessing 1,2,3-triazolium charged units by associating "click reaction" with efficient 1,2,3-triazole quaternization were designed and synthesized. Their free radical-scavenging activity against three free radicals was tested. The inhibitory property and water solubility of the synthesized chitosan derivatives exhibited a remarkable improvement over chitosan. It is hypothesized that triazole or triazolium groups enable the synthesized chitosan to possess obviously better radical-scavenging activity. Moreover, the scavenging activity against superoxide radical of chitosan derivatives with triazolium (IC50 < 0.01 mg mL(-1)) was more efficient than that of derivatives with triazole and Vitamin C. In the 1,1-diphenyl-2-picrylhydrazyl (DPPH) and hydroxyl radical-scavenging assay, the same pattern were observed, which should be related to the triazolium grafted at the periphery of molecular chains. |
| Keyword | chitosan derivatives 1,2,3-triazolium free radical-scavenging activity |
| Funding Organization | National Natural Science Foundation of China ; Natural Science Foundation of Shandong Province of China ; Yantai Science and Technology Development Plan ; Technology Research Funds Projects of Ocean |
| DOI | 10.3390/md16040107 |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | National Natural Science Foundation of China[41576156] ; Natural Science Foundation of Shandong Province of China[ZR2017BD015] ; Yantai Science and Technology Development Plan[2015ZH078] ; Technology Research Funds Projects of Ocean[2015418022-3] |
| WOS Research Area | Pharmacology & Pharmacy |
| WOS Subject | Chemistry, Medicinal |
| WOS ID | WOS:000431068000009 |
| Publisher | MDPI |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.imr.ac.cn/handle/321006/127933 |
| Collection | 中国科学院金属研究所 |
| Corresponding Author | Guo, Zhanyong |
| Affiliation | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Shangdong, Peoples R China 2.Grad Sch Chinese Acad Sci, Beijing 100039, Peoples R China 3.Alliance Pharma Inc, 17 Lee Blvd, Malvern, PA 19355 USA |
| Recommended Citation GB/T 7714 | Li, Qing,Sun, Xueqi,Gu, Guodong,et al. Novel Water Soluble Chitosan Derivatives with 1,2,3-Triazolium and Their Free Radical-Scavenging Activity[J]. MARINE DRUGS,2018,16(4):13. |
| APA | Li, Qing,Sun, Xueqi,Gu, Guodong,&Guo, Zhanyong.(2018).Novel Water Soluble Chitosan Derivatives with 1,2,3-Triazolium and Their Free Radical-Scavenging Activity.MARINE DRUGS,16(4),13. |
| MLA | Li, Qing,et al."Novel Water Soluble Chitosan Derivatives with 1,2,3-Triazolium and Their Free Radical-Scavenging Activity".MARINE DRUGS 16.4(2018):13. |
| Files in This Item: | There are no files associated with this item. | |||||
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment