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Novel Water Soluble Chitosan Derivatives with 1,2,3-Triazolium and Their Free Radical-Scavenging Activity
Li, Qing1; Sun, Xueqi1,2; Gu, Guodong3; Guo, Zhanyong1
Corresponding AuthorGuo, Zhanyong(zhanyongguo@hotmail.com)
2018-04-01
Source PublicationMARINE DRUGS
ISSN1660-3397
Volume16Issue:4Pages:13
AbstractChitosan is an abundant and renewable polysaccharide, which exhibits attractive bioactivities and natural properties. Improvement such as chemical modification of chitosan is often performed for its potential of providing high bioactivity and good water solubility. A new class of chitosan derivatives possessing 1,2,3-triazolium charged units by associating "click reaction" with efficient 1,2,3-triazole quaternization were designed and synthesized. Their free radical-scavenging activity against three free radicals was tested. The inhibitory property and water solubility of the synthesized chitosan derivatives exhibited a remarkable improvement over chitosan. It is hypothesized that triazole or triazolium groups enable the synthesized chitosan to possess obviously better radical-scavenging activity. Moreover, the scavenging activity against superoxide radical of chitosan derivatives with triazolium (IC50 < 0.01 mg mL(-1)) was more efficient than that of derivatives with triazole and Vitamin C. In the 1,1-diphenyl-2-picrylhydrazyl (DPPH) and hydroxyl radical-scavenging assay, the same pattern were observed, which should be related to the triazolium grafted at the periphery of molecular chains.
Keywordchitosan derivatives 1,2,3-triazolium free radical-scavenging activity
Funding OrganizationNational Natural Science Foundation of China ; Natural Science Foundation of Shandong Province of China ; Yantai Science and Technology Development Plan ; Technology Research Funds Projects of Ocean
DOI10.3390/md16040107
Indexed BySCI
Language英语
Funding ProjectNational Natural Science Foundation of China[41576156] ; Natural Science Foundation of Shandong Province of China[ZR2017BD015] ; Yantai Science and Technology Development Plan[2015ZH078] ; Technology Research Funds Projects of Ocean[2015418022-3]
WOS Research AreaPharmacology & Pharmacy
WOS SubjectChemistry, Medicinal
WOS IDWOS:000431068000009
PublisherMDPI
Citation statistics
Cited Times:9[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/127933
Collection中国科学院金属研究所
Corresponding AuthorGuo, Zhanyong
Affiliation1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Shangdong, Peoples R China
2.Grad Sch Chinese Acad Sci, Beijing 100039, Peoples R China
3.Alliance Pharma Inc, 17 Lee Blvd, Malvern, PA 19355 USA
Recommended Citation
GB/T 7714
Li, Qing,Sun, Xueqi,Gu, Guodong,et al. Novel Water Soluble Chitosan Derivatives with 1,2,3-Triazolium and Their Free Radical-Scavenging Activity[J]. MARINE DRUGS,2018,16(4):13.
APA Li, Qing,Sun, Xueqi,Gu, Guodong,&Guo, Zhanyong.(2018).Novel Water Soluble Chitosan Derivatives with 1,2,3-Triazolium and Their Free Radical-Scavenging Activity.MARINE DRUGS,16(4),13.
MLA Li, Qing,et al."Novel Water Soluble Chitosan Derivatives with 1,2,3-Triazolium and Their Free Radical-Scavenging Activity".MARINE DRUGS 16.4(2018):13.
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