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Hygroscopicity modulation of hydrogels based on carboxymethyl chitosan/Alginate polyelectrolyte complexes and its application as pH-sensitive delivery system
Lv, Xiaojie1,2; Zhang, Wenchang1; Liu, Yunen3; Zhao, Yan1; Zhang, Jinsong1; Hou, Mingxiao3
Corresponding AuthorZhao, Yan(yanzhao@imr.ac.cn) ; Zhang, Jinsong(jshzhang@imr.ac.cn)
2018-10-15
Source PublicationCARBOHYDRATE POLYMERS
ISSN0144-8617
Volume198Pages:86-93
AbstractPolyelectrolyte complex (PECs) hydrogels with high hygroscopicity modulation ability were successfully prepared based on carboxymethyl chitosan (CMCS)/alginate. The swelling ratio of the hydrogels could be tuned from 1 to 450 simply by changing the weight ratio of CMCS to alginate, and superabsorbent hydrogels were obtained when the weight ratio of CMCS to alginate was below 1/1. Also, the swelling kinetics and water diffusion mechanism in the hydrogels were discussed. In vitro cytotoxicity results indicated that hydrogels had excellent cytocompatibility. The swelling ratio of the hydrogel as well as its BSA releasing profile was notably pH dependent. Compared with the values at pH 1.2, the swelling ratio of hydrogels (CMCS/alginate weight ratio of 1/2) at pH 7.4 was about 34 times higher, and the amount of BSA released at pH 7.4 was also significantly higher. The as-prepared CMCS/alginate PECs hydrogels hold great potential for oral delivery of protein drugs through the intestinal tract.
KeywordPolyelectrolyte complex hydrogels pH-sensitive Superabsorbent Electrostatic Interactions Oral drug delivery
Funding OrganizationNational Key Research and Development Plan ; National Natural Science Foundation of China
DOI10.1016/j.carbpol.2018.06.058
Indexed BySCI
Language英语
Funding ProjectNational Key Research and Development Plan[2016YFB0301502] ; National Natural Science Foundation of China[U1608255]
WOS Research AreaChemistry ; Polymer Science
WOS SubjectChemistry, Applied ; Chemistry, Organic ; Polymer Science
WOS IDWOS:000440785200011
PublisherELSEVIER SCI LTD
Citation statistics
Cited Times:23[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.imr.ac.cn/handle/321006/129003
Collection中国科学院金属研究所
Corresponding AuthorZhao, Yan; Zhang, Jinsong
Affiliation1.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Liaoning, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Gen Hosp Shenyang Mil Command, Dept Emergency Med, Shenyang 110016, Liaoning, Peoples R China
Recommended Citation
GB/T 7714
Lv, Xiaojie,Zhang, Wenchang,Liu, Yunen,et al. Hygroscopicity modulation of hydrogels based on carboxymethyl chitosan/Alginate polyelectrolyte complexes and its application as pH-sensitive delivery system[J]. CARBOHYDRATE POLYMERS,2018,198:86-93.
APA Lv, Xiaojie,Zhang, Wenchang,Liu, Yunen,Zhao, Yan,Zhang, Jinsong,&Hou, Mingxiao.(2018).Hygroscopicity modulation of hydrogels based on carboxymethyl chitosan/Alginate polyelectrolyte complexes and its application as pH-sensitive delivery system.CARBOHYDRATE POLYMERS,198,86-93.
MLA Lv, Xiaojie,et al."Hygroscopicity modulation of hydrogels based on carboxymethyl chitosan/Alginate polyelectrolyte complexes and its application as pH-sensitive delivery system".CARBOHYDRATE POLYMERS 198(2018):86-93.
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